An observational study in Sensorineural Hearing Loss, Turner Syndrome and Inner Ear Disease, sponsored by Gødstrup Hospital. Recruiting at 1 site in Denmark. Open to female participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-11.
Sponsored by Gødstrup Hospital · Observational
The goal of this case-control study is to pave the way for new revolutionary treatment measures within hearing loss that could either replace or delay the need for hearing aids. The study focuses on people with Turner syndrome (TS).
The aim is to find out if there are specific DNA methylation patterns and/or RNA expression profiles linked to sensorineural hearing loss (SNHL) in people with TS. Additionally, the structure and function of the inner ear in these individuals will be examined to see if there is a connection to their epigenetic profile.
The main question it aims to answer is: Does epigenetics constitute a common denominator for some of the unexplained SNHL cases?
Turner Syndrome (TS) represents an ideal model for studying epigenetics related to sensorineural hearing loss (SNHL).
Participants will undergo the following tests:
346 studies on the registry are indexed under Hearing Loss, Sensorineural; 100 are open to participants now.
This study's planned enrollment of 150 is above the median of 70 across 86 observational studies indexed under Hearing Loss, Sensorineural.
Browse Hearing Loss, Sensorineural studies →Gødstrup Hospital is the lead sponsor of 24 studies on the registry; 14 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Three different populations will be included as it is expected that 50% of the TS population suffer from SNHL:
The participants are recruited from an existing cohort.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Individuals with TS and SNHL
Individuals with TS without SNHL
Healthy age matched controls without TS and without SNHL
Epigenetic profile
DNA methylation analyses are conducted on the purified DNA. RNA expression analyses and ChIP-seq are performed on the purified RNA. Based on this, the epigenetic profile will be mapped to identify consistent differences associated with SNHL.
Time frame: 2024-2026
Hearing ability
Hearing level thresholds and bone conduction is assesed by pure tone audiometry.
Time frame: 2024-2026
Vestibular status
The vestibular function is assessed using the video head impulse test (vHIT), vestibular evoked myogenic potentials, and posturography.
Time frame: 2024-2026
Structural malformations
Anatomy and inner ear malformations are examined using Conebeam CT and MRI.
Time frame: 2024-2026
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Gødstrup Hospital