An interventional study of Exercise in Type 1 Diabetes (T1D), sponsored by Liverpool John Moores University. Recruiting at 1 site in United Kingdom. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-01-14.
Sponsored by Liverpool John Moores University · Not applicable, Interventional, and Basic science
Among 268 studies in Diabetes Mellitus, Type 1 with a site in United Kingdom — 32 open to participants now, 42 under way, 5 of them phase 3. Diabetes Mellitus, Type 1 · United Kingdom.
Among the 268 studies in Diabetes Mellitus, Type 1 with a site in United Kingdom, this one is the 122nd largest by planned enrollment of the 214 interventional ones, is one of 12 that started in 2025, is one of 106 with no phase, reaches primary completion later than 15 of the 41 other live ones, and was the 263rd registered.
3,754 studies on the registry are indexed under Diabetes Mellitus, Type 1; 600 are open to participants now.
This study's planned enrollment of 38 is close to the median of 40 across 2,820 interventional studies indexed under Diabetes Mellitus, Type 1.
Browse Diabetes Mellitus, Type 1 studies →32 of the 268 studies in Diabetes Mellitus, Type 1 with a site in United Kingdom are open now, in 12 countries. Each count lists the studies.
Of the 411 Diabetes Mellitus, Type 1 studies recruiting now, 128 (31%) set no upper age limit and 257 (63%) stop at 75 or younger; 184 take children under 18; 64 take healthy volunteers.
This study: 18 Years to 65 Years · all sexes · no healthy volunteers.
The full table on the hub →268 studies; the count open now beside each. This study's row is marked.
First in 1997; this study’s year is marked. 12 started in 2025.
Median enrollment 50 across the 214 interventional studies, 133 across the 54 observational. Of the 205 that completed or were terminated, 76 (37%) have results posted.
98 of 268 have an industry lead sponsor. The 10 most frequent:
Liverpool John Moores University is the lead sponsor of 75 studies on the registry; 13 are open to participants now.
Liverpool John Moores University has 9 studies filed under Diabetes Mellitus, Type 1 — fewer than ten, so there is no comparison to draw.
16 of the studies in Diabetes Mellitus, Type 1 with a site in United Kingdom that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT04598893Provention Bio, a Sanofi CompanyRecent-Onset Type 1 Diabetes Extension Study Evaluating the Long-Term Safety of Teplizumab (PROTECT Extension) | 2026-11 |
| NCT07341243Liverpool John Moores UniversityExercising in Hot Conditions: How Does it Effect Blood Glucose in People With T1D | 2026-11-01 |
| NCT07457580SanofiReal-World Study of Patients With Type 1 Diabetes Treated With Teplizumab as Part of Managed Access Programs (MAPs) | 2026-11-30 |
| NCT06782568Imperial College LondonAvoidance of Insulin-induced Lipohypertophy in People With Diabetes Using Ultrasound Scanning Within Diabetes Clinics | 2026-12-31 |
| NCT07583238University of NottinghamDiathermy On Diabetes Glucose Monitoring Effectiveness | 2027-02 |
Among the 268 studies in Diabetes Mellitus, Type 1 with a site in United Kingdom, from their registry updates:
A randomised, crossover, counterbalanced repeated measures study will be conducted to examine the effect of acute heat exposure on rate of change in blood glucose concentration during 40 minutes of moderate-intensity exercise and for 30 minutes after exercise. Participants will complete two experimental conditions during two separate laboratory visits, with the order of conditions randomised. One condition will be a temperate condition of 20°C with 50% relative humidity (Temperate), the other will be 40°C with 50% relative humidity (Heat). Visits will be identical, including time of day, except for the condition. Visits will be separated by 24h. Testing will take place in the laboratories of the Research Institute for Sport and Exercise Sciences at Liverpool John Moores University.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Using insulin therapy with multiple daily injections (MDI), insulin pump (pump), or hybrid closed-loop (HCL)
o If using a HCL system have experience of using a pre-programmed basal rate in manual mode during exercise
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A blood test of average blood sugar over the past two to three months, given as a percentage or in mmol/mol. 6.5% (48 mmol/mol) or more is the usual threshold for diabetes, normally confirmed by a second test.
HbA1c
A blood test of average blood sugar over the past two to three months, given as a percentage or in mmol/mol. 6.5% (48 mmol/mol) or more is the usual threshold for diabetes, normally confirmed by a second test.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
40 minutes of moderate intensity continuous exercise at 20°C with 50% relative humidity
Behavioral: Exercise
40 minutes of moderate intensity continuous exercise at 40°C with 50% relative humidity
Behavioral: Exercise
exercise in the heat or temperate conditions
blood glucose
change in blood glucose concentration
Time frame: Baseline pre exercise to end of exercise (40 minutes)
Core temperature
change in core temperature
Time frame: Baseline pre exercise to end of exercise (40 minutes)
Skin temperature
change in skin temperature
Time frame: Baseline pre exercise to end of exercise (40 minutes)
Free fatty acids
change free fatty acid concentration
Time frame: Baseline pre exercise to end of exercise (40 minutes)
insulin
Change in insulin concentration
Time frame: Baseline pre exercise to end of exercise (40 minutes)
glucagon
change in glucagon concentration
Time frame: Baseline pre exercise to end of exercise (40 minutes)
epinephrine
change in epinephrine concentration
Time frame: Baseline pre exercise to end of exercise (40 minutes)
norepinephrine
change in norepinephrine concentration
Time frame: Baseline pre exercise to end of exercise (40 minutes)
cortisol
change in cortisol concentration
Time frame: Baseline pre exercise to end of exercise (40 minutes)
Growth hormone
change in Growth hormone concentration
Time frame: Baseline pre exercise to end of exercise (40 minutes)
lactate
change in lactate concentration
Time frame: Baseline pre exercise to end of exercise (40 minutes)
Plan to share: Yes — On request to PI
No publications or documents are linked to this record.
Started Nov 2025 (actual). Primary completion is estimated for Nov 2026, 12 months after the start.
Of 844 non-industry interventional studies with no phase under Diabetes Mellitus, Type 1, half reached primary completion within 19 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 38. This study's planned 12 months is below that.
Counting every sponsor, half of 949 studies reached it within 18 months; a quarter within 9 and three quarters within 35.
How these figures are worked out, and which studies are left out of them.
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Liverpool John Moores University