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Not yet recruitingNCT07323225RCTUpdated Jan 7, 2026

Neural Mobilization and Capsular Stretching in Adhesive Capsulitis

An interventional study of capsular stretching plus neural mobilization and anterior, inferior and posterior capsular stretching in Adhesive Capsulitis, sponsored by Prince Sattam Bin Abdulaziz University. Not yet recruiting at 1 site in Saudi Arabia. Open to participants aged 40 Years to 70 Years. Per ClinicalTrials.gov, last updated 2026-01-07.

Sponsored by Prince Sattam Bin Abdulaziz University · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
50
Allocation
Randomized
Ages
40 Years to 70 Years
Sex
All
01

Study summary

Restriction of glenohumeral (GH) mobility in patients with adhesive capsulitis (AC) was known owing to capsular adhesion. There is a little evidence about the involvement of neural restriction in limiting range of motion (ROM) of the GH joint in patients with AC. Objectives: The purpose of this study is to investigate the combined effect of median nerve mobilization and capsular stretching on improving shoulder external rotation, abduction and internal rotation ROM among patients with AC. Methods Thirty patients will be randomly assigned into two equal groups : Group (A) will receive median nerve mobilization and capsular stretching while Group (B) will receive only capsular stretching (anterior, posterior and anteroinferior capsular stretching). Both groups will receive passive and self-assisted exercises. All patients in both groups will be evaluated pre and post treatment for GH external rotation, abduction and internal rotation ROM.

02

Conditions studied

  • Adhesive Capsulitis

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Keywords

  • Adhesive capsulitis
  • neural mobilization
  • capsular stretch
03

Who can participate

Ages eligible
40 Years to 70 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Patients from both gender (male \&female) will be included if they would have second or third stage AC with their age between forty and seventy years
  • experiencing pain, capsular adhesions, and a reduction of greater than fifty percentage in passive ROM of the GH joint (external rotation, abduction, and internal rotation compared to the sound side
  • lasting for a minimum of three months. Patients with positive upper limb tension test-1 will be also included in this study

Exclusion criteria

Exclusion Criteria:

  • they would have stroke,Parkinson's diseases that interfere with shoulder muscles activity
  • diabetes
  • traumatic shoulder conditions
  • glenohumeral osteoarthritis confirmed by x-ray
  • previous surgery, and manipulation of the affected GH joint under general anesthesia
  • Patients with passive elbow extension ROM
04

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
50 participants (estimated)

Study arms

  • Experimental
    Neural mobilization group

    neural mobilization plus capsular stretching

    Other: capsular stretching plus neural mobilization

  • Active comparator
    Capsular stretching group

    capsular stretching

    Other: anterior, inferior and posterior capsular stretching

  • Active comparator
    Control group

    traditional execises

    Other: traditional exercises

Interventions

  • Othercapsular stretching plus neural mobilization

    anterior, posterior and inferior capsular stretching and neural mobilization

  • Otheranterior, inferior and posterior capsular stretching

    anterior, inferior and posterior glenohumeral capsular stretching

  • Othertraditional exercises

    stretching exercises for anterior GH musculture plus auto passive exercises and pendulum exercises

05

What researchers measure

Primary outcomes

  1. pain intensity

    pain was assessed by VAS which has two ends. the left end indicates no pain where the right end indicates maximal pain

    Time frame: 4 Weeks

  2. central sensitization

    central sensitization will be assessed by the the arabic version of central sensitizatuion questionnaire. To understand CSI scores, the following severity categories have been established: subclinical = 0 to 29; mild = 30 to 39; moderate = 40 to 49; severe = 50 to 59; and extreme = 60 to 100

    Time frame: 4 weeks

06

Study locations

1 site
  • Prince Sattam bin Abdulaziz University
    Al Kharj, 16242, Saudi Arabia
07

References and documents

Publications

  • Coppieters MW, Butler DS. Do 'sliders' slide and 'tensioners' tension? An analysis of neurodynamic techniques and considerations regarding their application. Man Ther. 2008 Jun;13(3):213-21. doi: 10.1016/j.math.2006.12.008. Epub 2007 Mar 30. PubMed 17398140 ↗
  • Martinez-Merinero P, Lluch E, Gallezo-Izquierdo T, Pecos-Martin D, Plaza-Manzano G, Nunez-Nagy S, Falla D. The influence of a depressed scapular alignment on upper limb neural tissue mechanosensitivity and local pressure pain sensitivity. Musculoskelet Sci Pract. 2017 Jun;29:60-65. doi: 10.1016/j.msksp.2017.03.001. Epub 2017 Mar 10. PubMed 28319883 ↗

Individual participant data

Plan to share: No

08

Registry details

Key details

Study ID
NCT07323225
Lead sponsor
Prince Sattam Bin Abdulaziz University
Responsible party
Mohammad Moustafa Aldosoukki Hegazy (assisstant professor , department of health and rehabilitation sciences, college of applied medical siences, Prince Sattam Bin Abdulaziz University) — Principal investigator
First posted
Jan 7, 2026
Start date
Jan 1, 2026 (estimated)
Primary completion
Apr 1, 2026 (estimated)
Completion
Apr 10, 2026 (estimated)
Last update
Jan 7, 2026

Study contacts

Mohammed Hegazy
Contact
mohamed.mostafa@pt.cu.edu.eg
00966566169893 ext. 00966115886387

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Dec 2025. You cannot join it, but the record below documents what was studied.

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