An interventional study of Cardiopulmonary exercise test in Healthy, sponsored by Rigshospitalet, Denmark. Completed at 1 site in Denmark. Open to participants aged 18 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-01-06.
Sponsored by Rigshospitalet, Denmark · Not applicable, Interventional, and Other
Background Changes in cardiac output, driven by increased heart rate and stroke volume, are crucial for oxygen delivery during acute exercise and influence maximal oxygen uptake (VO₂max). Thoracic electrical bioimpedance provides a non-invasive alternative to traditional invasive methods by estimating stroke volume through impedance changes during ventricular filling and emptying. However, its test-retest reliability remains uncertain, requiring further investigation for use in acute and long-term training assessments.
Methods Inclusion: 12 healthy individuals (six males, six females) Exclusion: Known ischaemic heart disease, known heart failure, symptoms of disease within 2 weeks prior to the study, known malignant disease, claudication, pregnancy, unstable cardiac arrhythmic disease, renal or liver dysfunction, known chronic lung disease Design: Test-retest study of thoracic electrical bioimpedance-based stroke volume
Intervention: Acute exercise bout on a bicycle ergometer Statistical design: Rest-to-exercise changes, as well as between-day smallest real difference, coefficient of variation and intraclass correlation coefficient Sample size: Since this is a pilot study, the sample size is set at 12 in accordance with current recommendations.
Perspective The results are relevant for designing future studies in which stroke volume is measured and compared in response to various interventions at rest and during exercise.
Rigshospitalet, Denmark is the lead sponsor of 1,017 studies on the registry; 183 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion criteria
A cardiopulmonary exercise test (CPET), during which stroke volume and heart rate are continuously measured
Other: Cardiopulmonary exercise test
The two study days are identical, and consist of stroke volume, heart rate and non-invasive blood pressure measurements during upright rest, in the supine position, and during incremental exercise (CPET).
Between-day smallest real difference (SRD) for stroke volume during upright rest
Time frame: 2-10 days
Between-day coefficient of variance (CV) for for stroke volume during upright rest
Time frame: 2-10 days
Between-day smallest real difference (SRD) for stroke volume during supine rest
Time frame: 2-10 days
Between-day coefficient of variance (CV) for stroke volume during supine rest
Time frame: 2-10 days
Between-day SRD for stroke volume at 60% of maximal workload (Wmax) during CPET
Time frame: 2-10 days
Between-day CV for stroke volume at 60% of Wmax during CPET
Time frame: 2-10 days
Between-day SRD for stroke volume at 40% of Wmax during CPET
Time frame: 2-10 days
Between-day CV for stroke volume at 40% of Wmax during CPET
Time frame: 2-10 days
Between-day SRD for stroke volume at 80% of Wmax during CPET
Time frame: 2-10 days
Between-day CV for stroke volume at 80% of Wmax during CPET
Time frame: 2-10 days
Between-day SRD for stroke volume at Wmax during CPET
Time frame: 2-10 days
Between-day CV for stroke volume at Wmax during CPET
Time frame: 2-10 days
Between-day intraclass correlation coefficient (ICC) for stroke volume during upright rest
Time frame: 2-10 days
Between-day ICC for stroke volume during supine rest
Time frame: 2-10 days
Between-day ICC for stroke volume at 60% of Wmax during CPET
Time frame: 2-10 days
Between-day ICC for stroke volume at 40% of Wmax during CPET
Time frame: 2-10 days
Between-day ICC for stroke volume at 80% of Wmax during CPET
Time frame: 2-10 days
Between-day ICC for stroke volume at Wmax during CPET
Time frame: 2-10 days
Between-day SRD for cardiac output (measured as the product of stroke volume and heart rate) during upright rest
Time frame: 2-10 days
Between-day CV for for cardiac output during upright rest
Time frame: 2-10 days
Between-day ICC for for cardiac output during upright rest
Time frame: 2-10 days
Between-day SRD for cardiac output during supine rest
Time frame: 2-10 days
Between-day CV for for cardiac output during supine rest
Time frame: 2-10 days
Between-day ICC for for cardiac output during supine rest
Time frame: 2-10 days
Between-day SRD for cardiac output at 60% of Wmax during CPET
Time frame: 2-10 days
Between-day CV for cardiac output at 60% of Wmax during CPET
Time frame: 2-10 days
Between-day ICC for cardiac output at 60% of Wmax during CPET
Time frame: 2-10 days
Between-day SRD for cardiac output at 40% of Wmax during CPET
Time frame: 2-10 days
Between-day CV for cardiac output at 40% of Wmax during CPET
Time frame: 2-10 days
Between-day ICC for cardiac output at 40% of Wmax during CPET
Time frame: 2-10 days
Between-day SRD for cardiac output at 80% of Wmax during CPET
Time frame: 2-10 days
Between-day CV for cardiac output at 80% of Wmax during CPET
Time frame: 2-10 days
Between-day ICC for cardiac output at 80% of Wmax during CPET
Time frame: 2-10 days
Between-day SRD for cardiac output at Wmax during CPET
Time frame: 2-10 days
Between-day CV for cardiac output at Wmax during CPET
Time frame: 2-10 days
Between-day ICC for cardiac output at Wmax during CPET
Time frame: 2-10 days
Between-day SRD for heart rate (measured with the CPET equipment) during upright rest
Time frame: 2-10 days
Between-day CV for for heart rate during upright rest
Time frame: 2-10 days
Between-day ICC for for heart rate during upright rest
Time frame: 2-10 days
Between-day SRD for heart rate during supine rest
Time frame: 2-10 days
Between-day CV for for heart rate during supine rest
Time frame: 2-10 days
Between-day ICC for for heart rate during supine rest
Time frame: 2-10 days
Between-day SRD for heart rate at 60% of Wmax during CPET
Time frame: 2-10 days
Between-day CV for heart rate at 60% of Wmax during CPET
Time frame: 2-10 days
Between-day ICC for heart rate at 60% of Wmax during CPET
Time frame: 2-10 days
Between-day SRD for heart rate at 40% of Wmax during CPET
Time frame: 2-10 days
Between-day CV for heart rate at 40% of Wmax during CPET
Time frame: 2-10 days
Between-day ICC for heart rate at 40% of Wmax during CPET
Time frame: 2-10 days
Between-day SRD for heart rate at 80% of Wmax during CPET
Time frame: 2-10 days
Between-day CV for heart rate at 80% of Wmax during CPET
Time frame: 2-10 days
Between-day ICC for heart rate at 80% of Wmax during CPET
Time frame: 2-10 days
Between-day SRD for heart rate at Wmax during CPET
Time frame: 2-10 days
Between-day CV for heart rate at Wmax during CPET
Time frame: 2-10 days
Between-day ICC for heart rate at Wmax during CPET
Time frame: 2-10 days
Uright-to supine changes in stroke volume, heart-rate and cardiac output and arterial blood pressure at rest
Time frame: 2-10 days
Changes in stroke volume from upright rest to exercise at 40%, 60%, 80% and 100% of Wmax.
Time frame: 2-10 days
Changes in cardiac output from upright rest to exercise at 40%, 60%, 80% and 100% of Wmax.
Time frame: 2-10 days
Changes in arterial blood pressure from upright rest to exercise at 40%, 60%, 80% and 100% of Wmax.
Time frame: 2-10 days
Plan to share: No
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Rigshospitalet, Denmark