ClinicalTrials.gg
CompletedNCT07312669Updated Dec 31, 2025

ROP Check Database Premature Infant Outcomes

An observational study in Retinopathy of Prematurity (ROP), sponsored by Alaska Blind Child Discovery. Completed at 1 site in United States. Per ClinicalTrials.gov, last updated 2025-12-31.

Sponsored by Alaska Blind Child Discovery · Observational

Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
7,070
Sex
All
01

Study summary

The goal of this observation of multi-centered care of infants covered by ROP Check cloud-based database is to compare demographic and clinical risk factors to evaluate and improve vision-protecting guidelines.

Read the detailed description

Infants from multiple academic and community hospital neonatal intensive care units (NICUs) and their covering ophthalmologists had the serial eye examination and treatment data covered by ROP Check® cloud-based database. ROP Check assists neonatologists to implement guideline scheduling of infants according to the American Academy of Pediatrics (AAP). Outcome included progression to Type 1 retinopathy of prematurity (ROP) and treatment details such as intra-vitreal anti-VEGF injection and peripheral ablative laser. demographic data including birthweight, gestational age, gender, race/ethnicity are analyzed to determine risk factors severe ROP. Blindness-preventing guidelines are reviewed, analyzed and evidence-based updates are proposed.

02

Conditions studied

  • Retinopathy of Prematurity (ROP)

Keywords

  • gestational age, birthweight, race, gender
03

In context

Retinopathy of Prematurity

169 studies on the registry are indexed under Retinopathy of Prematurity; 27 are open to participants now.

This study's enrollment of 7,070 is above the median of 175 across 57 observational studies indexed under Retinopathy of Prematurity.

Browse Retinopathy of Prematurity studies →

Lead sponsor

Alaska Blind Child Discovery is the lead sponsor of 11 studies on the registry; 1 is open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

NICU babies eligible for ROP examination

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • NICU infants

Exclusion criteria

Exclusion Criteria:

  • Term birth
05

Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
7,070 participants (actual)
Patient registry
No
06

What researchers measure

Primary outcomes

  1. ROP treatment: After examination, whether an infant reaching criteria for treatment and what treatment was given. Document the number and the proportion needing treatment.

    Type 1 ROP

    Time frame: 2010 through 2022

07

Study locations

1 site
  • Alaska Children's EYE & Strabismus
    Anchorage, Alaska 99508, United States
08

References and documents

Publications

  • Arnold RW, Jacob J, Matrix Z. Toward Achieving 100% Adherence for Retinopathy of Prematurity Screening Guidelines. J Pediatr Ophthalmol Strabismus. 2017 Nov 1;54(6):356-362. doi: 10.3928/01913913-20170329-04. Epub 2017 Aug 29. PubMed 28850643 ↗

Study documents

PDFs hosted by the registry, ClinicalTrials.gov.

Individual participant data

Plan to share: Undecided — Interest level of other parties

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Ran from Jan 2010 to primary completion in Dec 2022, 155 months.

How these figures are worked out, and which studies are left out of them.

Registered
Nov 23, 2025
First posted
Dec 31, 2025
StartActual
Jan 1, 2010
Primary completionActual
Dec 31, 2022
CompletionActual
Dec 31, 2022
Last update
Dec 31, 2025
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Dec 31, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07312669
Lead sponsor
Alaska Blind Child Discovery
Responsible party
Sponsor
First posted
Dec 31, 2025
Start date
Jan 1, 2010
Primary completion
Dec 31, 2022
Completion
Dec 31, 2022
Last update
Dec 31, 2025

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Dec 2025. You cannot join it, but the record below documents what was studied.

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Discussion

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