Clinical and Radiographic Assessment of Efficacy of Modified Minimally Invasive SurgicalTechnique (M-MIST) Alone and Combined With Enamel Matrix Proteins and Ox-derived Bone Graft in the Treatment of Single Bone Defects Between Teeth.

Browse trials for

• Periodontal Diseases 830
• Alveolar Bone Loss 297

Periodontal Diseases

830 studies on the registry are indexed under Periodontal Diseases; 189 are open to participants now.

This study's enrollment of 45 is close to the median of 45 across 530 interventional studies indexed under Periodontal Diseases.

Lead sponsor

Rungta College of Dental Sciences and Research is the lead sponsor of 4 studies on the registry; none are open to participants now.

Study arms

• Placebo comparator
  modified minimally invasive surgical technique

  Procedure: modified minimally invasive surgical technique

• Active comparator
  modified minimally invasive surgical technique with emdogain

  Procedure: modified minimally invasive surgical technique plus emdogain

• Experimental
  modified minimally invasive surgical technique with emdogain and xenograft

  Procedure: modified minimally invasive surgical technique plus emdogain and xenograft

Interventions

• Proceduremodified minimally invasive surgical technique

  modified minimally invasive surgical technique alone in interdental area

• Proceduremodified minimally invasive surgical technique plus emdogain

  modified minimally invasive surgical technique with application of enamel matrix proteins in interdental area

• Proceduremodified minimally invasive surgical technique plus emdogain and xenograft

  modified minimally invasive surgical technique with application of enamel matrix proteins and placement of bovine bone graft in interdental area

Primary outcomes

1. Probing Pocket Depth

   The depth of probe penetration into the pocket (millimeters) is measured from the gingival margin using an UNC-15 probe.

   Time frame: 24 weeks

2. Clinical Attachment Level

   The distance from the base of the pocket to cemento-enamel junction (millimeters) is measured using an UNC-15 probe.

   Time frame: 24 weeks

Secondary outcomes

1. Full mouth plaque score

   Turesky Modification of Quigley-Hein Index used to assess plaque buildup across all tooth surfaces (buccal, lingual, mesial, distal) with scoring 0 (no plaque) to 5 (heavy plaque)

   Time frame: 24 weeks

2. Full mouth bleeding score

   Probe is inserted and withdrawn at the distal point of the tooth and monitored for bleeding within 10 seconds. Registered with (+) availability of provoked bleeding and with (-) its absence.

   Time frame: 24 weeks

3. Mean defect depth

   measured as the distance fromt the alveolar crest to the base of the defect (in CBCT)

   Time frame: 24 weeks

Publications

• Cortellini P, Tonetti MS. Clinical and radiographic outcomes of the modified minimally invasive surgical technique with and without regenerative materials: a randomized-controlled trial in intra-bony defects. J Clin Periodontol. 2011 Apr;38(4):365-73. doi: 10.1111/j.1600-051X.2011.01705.x. Epub 2011 Feb 8. PubMed 21303402 ↗
• Cortellini P, Pini Prato G, Tonetti MS. Periodontal regeneration of human infrabony defects. II. Re-entry procedures and bone measures. J Periodontol. 1993 Apr;64(4):261-8. doi: 10.1902/jop.1993.64.4.261. PubMed 8483088 ↗
• Cortellini P, Pini Prato G, Tonetti MS. Periodontal regeneration of human infrabony defects. I. Clinical measures. J Periodontol. 1993 Apr;64(4):254-60. doi: 10.1902/jop.1993.64.4.254. PubMed 8483087 ↗
• Camelo M, Nevins ML, Lynch SE, Schenk RK, Simion M, Nevins M. Periodontal regeneration with an autogenous bone-Bio-Oss composite graft and a Bio-Gide membrane. Int J Periodontics Restorative Dent. 2001 Apr;21(2):109-19. PubMed 11829385 ↗

Individual participant data

Plan to share: Undecided