An interventional study of Selective movement of individual lower limb joints and Knee joint strengthening at high velocities in Spastic Cerebral Palsy, sponsored by University of California, Los Angeles. Completed at 1 site in United States. Open to participants aged 5 Years to 18 Years. Per ClinicalTrials.gov, last updated 2026-01-09.
Sponsored by University of California, Los Angeles · Not applicable, Interventional, and Treatment
The goal of this intervention study is to learn whether a physical therapy exercise camp called will improve leg movement (motor control) and functional ability in children with spastic CP who are between 5 and 18 years. The main questions the study aims to answer are:
All participants will:
Measurements:
MRI measurements will be taken twice (before and immediately after the treatment). All other measurements and will be taken 3 times (before, immediately after the treatment and approximately 4 months after the treatment).
1,853 studies on the registry are indexed under Cerebral Palsy; 435 are open to participants now.
This study's enrollment of 23 is below the median of 33 across 1,368 interventional studies indexed under Cerebral Palsy.
Browse Cerebral Palsy studies →University of California, Los Angeles is the lead sponsor of 1,142 studies on the registry; 192 are open to participants now.
Of its 91 completed or terminated interventional studies of FDA-regulated products, 66 (73%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
All participants
For participants undergoing MRI
physical therapy exercise intervention
Other: Selective movement of individual lower limb joints · Other: Knee joint strengthening at high velocities · Other: Ankle controlled gaming · Other: Functional activities based on child and parental goals · Other: Sensori-motor exercises
Children practices moving the joints of each lower leg independently.
In sitting, the thigh and trunk are secured to a seat and the lower leg to a moving arm that provides resistance at exercise velocities progressing up to a maximum of 300 deg/s.
With the child in sitting, the ankle is secured to a moving segment. The child can control games such as tennis by dorsiflexing and plantar flexing their ankle at increasing velocities to meet the demands of the game.
The Canadian Occupational Performance Measure is used to identify functional goals. Activities to address these goals are designed by physical therapists and practiced during camp.
Walking barefoot over sand and grass. Foot and ankle sensory exploration using materials with various textures.
Gross Motor Function Measure
Children are asked to perform functional activities including standing, walking, running, balancing and stair climbing. The data are entered into a computer program to create a score ranging from 0-100. A higher score indicates better function.
Time frame: nine months
Knee joint torque
Three repetitions of maximum effort knee extension and flexion torque are collected at 0-300 deg/s for the affected lower limbs. Outcomes are the percent of knee joints that can produce measurable torque at each velocity and the peak joint torque that is produced.
Time frame: nine months
Canadian Occupational Performance Measure
Parents/caregivers and children choose 5 activities that they would like to see improve as a result of this intervention. The parent or caregiver rates how well their child currently performs that task and how satisfied they are with the performance of the task on a scale of 1-10 with 10 being the highest score.
Time frame: nine months
Brain MRI - Diffusion tensor imaging
A brain MRI scan is obtained. Tract based spatial statistics are performed from the scan to look for changes in individual voxels. Higher values for fractional anisotropy are associated with improved tract integrity. Lower values for radial and median diffusivity are associated with improved myelination.
Time frame: nine months
Plan to share: No
This study is completed, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.
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University of California, Los Angeles