An interventional study of Behavioral Coaching Intervention and Virtual Exercise Platform in Hematological Malignancy, Leukemia and Lymphoid Leukemia, sponsored by University of Nebraska. Recruiting at 1 site in United States. Open to participants aged 50 Years and older. Per ClinicalTrials.gov, last updated 2026-07-01.
Sponsored by University of Nebraska · Not applicable, Interventional, and Supportive care
Older survivors of blood cancer are at a high risk of accelerated biological aging, which increases their risk of developing multiple aging-related conditions. Whereas physical exercise can improve overall health, older cancer survivors do not meet the recommended physical activity, highlighting the need to develop behavioral interventions to increase adherence. Several other knowledge gaps exist to implement exercise interventions in older survivors of blood cancer; the dose and duration of exercise necessary to slow biological aging in older blood cancer survivors remain unknown. To bridge these gaps in knowledge, we have designed a Phase 2 randomized control trial to test the effects of behavioral and exercise interventions on various outcomes.
1,444 studies on the registry are indexed under Hematologic Neoplasms; 420 are open to participants now.
This study's planned enrollment of 180 is above the median of 46 across 1,044 interventional studies indexed under Hematologic Neoplasms.
Browse Hematologic Neoplasms studies →University of Nebraska is the lead sponsor of 496 studies on the registry; 67 are open to participants now.
Of its 83 completed or terminated interventional studies of FDA-regulated products, 53 (64%) have results posted.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
The study doctor’s estimate of how long someone is likely to live. Criteria use it so that people can stay in the study long enough for it to answer its question.
Cancer (malignancy)
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Life expectancy
The study doctor’s estimate of how long someone is likely to live. Criteria use it so that people can stay in the study long enough for it to answer its question.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Intervention arm incorporating virtually supervised moderate-intensity aerobic exercise and behavioral intervention/coaching to improve adherence
Behavioral: Behavioral Coaching Intervention · Behavioral: Virtual Exercise Platform
Participants will receive access to a virtual exercise platform, and educational sessions but will not receive behavioral coaching
Behavioral: Virtual Exercise Platform
Intervention arm incorporating virtually supervised moderate-intensity aerobic exercise and behavioral intervention/coaching to improve adherence
Access to a virtual exercise platform that provides exercise classes and educational sessions for older survivors of blood cancer
Percentage of participants who adhered to the exercise regimen at 6-months post enrollment.
Participants achieving at least 120 minutes per week of moderate-intensity aerobic exercise, measured using Polar heart rate monitor data and exercise diaries.
Time frame: 6 Months from start of program
Percentage of participants who adhered to the exercise regimen at 12-months post enrollment.
Participants achieving at least 120 minutes per week of moderate-intensity aerobic exercise, measured using Polar heart rate monitor data and exercise diaries to assess sustainability of adherence.
Time frame: 12 Months from start of program.
Physical Function (6- Minute Walk Test Distance)
Distance covered during the 6-minute walk test (6MWT) to assess physical function.
Time frame: 6 months from randomization
Physical Function Maximal Oxygen Consumption (VO₂ max)
Maximal oxygen consumption measured during cardiopulmonary exercise testing (CPET)
Time frame: 6 months from randomization
Neuro-QOL Cognition Function Short Form Score
Subjective cognitive function assessed using the Neuro-QOL v2.0 Cognition Function Short Form
Time frame: 6 months from randomization
Trail Making Test Performance
Cognitive function assessed using Trail Making Test Parts A and B (TMT-A and TMT-B).
Time frame: 6 months from randomization
Controlled Oral Word Association Test Performance
Cognitive function assessed using the Controlled Oral Word Association Test (COWAT).
Time frame: 6 months from randomization
EORTC QLQ-C30 Score
Health-related quality of life assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30), version 3.0.
Time frame: 6 months from randomization
EQ-5D-5L Score
Health-related quality of life assessed using the EuroQol 5-Dimension 5-Level (EQ-5D-5L) instrument.
Time frame: 6 months from randomization
Biological Age by Epigenetic Clock
Change in biological age assessed using epigenetic clock biomarkers based on DNA methylation analysis.
Time frame: 6 months from randomization
Plan to share: No
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