An interventional study of iWalk Program in Neurodegenerative Disease, EEG and Mindfulness, sponsored by University of Illinois at Urbana-Champaign. Recruiting at 1 site in United States. Open to participants aged 18 Years to 110 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-12-16.
Sponsored by University of Illinois at Urbana-Champaign · Not applicable, Interventional, and Treatment
This study is a randomized controlled trial of the walking meditation intervention (iWalk) program, a multi-component intervention integrating walking meditation, education, and group sessions designed to enhance resilience in individuals with multiple sclerosis (MS).
The objectives are to evaluate:
The iWalk Program is an 8-week, multi-component behavioral intervention integrating mindfulness-based stress reduction and walking meditation to promote resilience and self-regulation in people with MS. The intervention combines weekly educational content, guided walking meditation, and group reflection delivered both in-person and virtually. Participants in the experimental group will attend three one-hour sessions per week (two via Zoom, one in-person) focusing on mindfulness, interoception, emotional regulation, and positive coping.
The waitlist control group will receive usual care during the trial period and will be offered participation after study completion.
Assessments include psychological questionnaires, electroencephalography (EEG), cognitive tasks, balance testing, and physical activity monitoring using Fitbit and Hexoskin wearable sensors. Data analysis includes assessing quantitative and qualitative changes in resilience, stress, mindfulness, mood, interoceptive awareness, quality of life, and physical activity over 8 weeks.
The total study duration is 10 weeks per participant, including baseline and post-intervention assessments.
370 studies on the registry are indexed under Neurodegenerative Diseases; 145 are open to participants now.
This study's planned enrollment of 90 is above the median of 53 across 204 interventional studies indexed under Neurodegenerative Diseases.
Browse Neurodegenerative Diseases studies →University of Illinois at Urbana-Champaign is the lead sponsor of 188 studies on the registry; 29 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Participants who cannot speak, read, write, or listen in English.
This group receives the complete iWalk program.
Behavioral: iWalk Program
This group receives only education part of the iWalk program without walking mindfulness sessions.
Behavioral: iWalk Program
This group does not receive any intervention and are placed on a waiting list.
A multi-component behavioral program integrating walking meditation, education, and group sessions to enhance resilience and stress regulation in adults with and without chronic conditions.
Connor Davidson Resilience Scale for Adults (CD-RISC 25)
Time frame: The baseline means assessments done two weeks before the intervention start date. Post-intervention assessments will be conducted two weeks after the intervention. Follow-up 1 is 24 weeks from baseline, and follow-up 2 is 48 weeks from baseline.
Multiple Sclerosis Resilience Scale (MSRS)
Time frame: The baseline means assessments done two weeks before the intervention start date. Post-intervention assessments will be conducted two weeks after the intervention. Follow-up 1 is 24 weeks from baseline, and follow-up 2 is 48 weeks from baseline.
Stroop Task
Time frame: The baseline means assessments done two weeks before the intervention start date. Post-intervention assessments will be conducted two weeks after the intervention. Follow-up 1 is 24 weeks from baseline, and follow-up 2 is 48 weeks from baseline.
Symbol Digit Modalities Test
Time frame: The baseline means assessments done two weeks before the intervention start date. Post-intervention assessments will be conducted two weeks after the intervention. Follow-up 1 is 24 weeks from baseline, and follow-up 2 is 48 weeks from baseline.
Wisconsin Card Sorting Test
Time frame: The baseline means assessments done two weeks before the intervention start date. Post-intervention assessments will be conducted two weeks after the intervention. Follow-up 1 is 24 weeks from baseline, and follow-up 2 is 48 weeks from baseline.
Sustained Attention to Response Task
Time frame: The baseline means assessments done two weeks before the intervention start date. Post-intervention assessments will be conducted two weeks after the intervention. Follow-up 1 is 24 weeks from baseline, and follow-up 2 is 48 weeks from baseline.
Plan to share: No
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University of Illinois at Urbana-Champaign