An interventional study of dichoptic videos and standard videos in Intermittent Exotropia, sponsored by Retina Foundation of the Southwest. Recruiting at 1 site in United States. Open to participants aged 4 Years to 10 Years. Per ClinicalTrials.gov, last updated 2026-04-08.
Sponsored by Retina Foundation of the Southwest · Not applicable, Interventional, and Treatment
To determine whether use of dichoptic movies for 8 weeks may be helpful in improving control alignment in children with intermittent exotropia (IXT), thus allowing IXT to be managed non-surgically
Intermittent exotropia (IXT) is the most common form of strabismus, characterized by an outward deviation of the eyes that is primarily manifest during distance fixation and can intermittently be controlled by fusional mechanisms. Less than 30% of children have good long-term outcomes following treatment for spontaneously manifest IXT with current non-surgical treatments (prism therapy, over-minus lenses, or vision therapy). The limited efficacy of current non-surgical treatments for IXT is thought to arise from underlying sensory deficits, particularly interocular suppression, which compromises binocular function. This underscores the need for sensory-directed interventions aimed at reducing suppression and thereby enhancing the potential for stable binocular outcomes.
In this study, children will be randomized to watch engaging videos streamed at home that are either dichoptic or standard (control) format. The aim is to determine whether the dichoptic format will decrease suppression and improve control of eye alignment . In previous research, use of dichoptic games and movies by children with amblyopia has shown to reduce suppression.
Exclusion Criteria:
dichoptic videos streamed at home 1 hour per day, 5 days per week
Other: dichoptic videos
standard videos streamed at home 1 hour per day, 5 days per week
Other: standard videos
custom designed dichoptic videos
standard videos
Improvement in control of intermittent exotropia
change percent time alignment is present at 8 weeks vs at baseline
Time frame: 8 weeks
Improvement in control of intermittent exotropia
change percent time alignment is present at 4 weeks vs at baseline
Time frame: 4 weeks
Improvement in control of intermittent exotropia
change percent time alignment is present at 12 weeks off-treatment weeks vs at baseline
Time frame: 12 weeks off-treatment
Change in distance stereoacuity
change in Distance Randot test score at 4 weeks vs at baseline
Time frame: 4 weeks
Change in distance stereoacuity
change in Distance Randot test score at 8 weeks vs at baseline
Time frame: 8 weeks
Change in distance stereoacuity
change in Distance Randot test score at 12 weeks off-treatment vs at baseline
Time frame: 12 weeks off-treatment
Change in quality of life
Change in IXTQ questionnaire (Rasch-scored on a 0-100 scale) at 8 weeks vs at baseline
Time frame: 8 weeks
Change in quality of life
Change in IXTQ questionnaire (Rasch-scored on a 0-100 scale) ay 12 weeks off-treatment vs at baseline
Time frame: 12 weeks off-treatment
Plan to share: No
No publications or documents are linked to this record.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Retina Foundation of the Southwest