A Phase 4 interventional study of Collagen Matrix soft tissue graft in Extraction Socket Healing and Extraction, Tooth, sponsored by Altinbas University. Active, not recruiting at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-12-08.
Sponsored by Altinbas University · Phase 4, Interventional, and Treatment
This study is aimed at assessing the effect of an animal-derived collagen matrix on bone and soft tissues in the human teeth. Single-rooted teeth that are beyond restoration and in need of extraction will be included in the study. Patients will be divided into two comparable groups in a randomized manner. The first group will proceed with tooth extraction only, which will be left for spontaneous healing. The second (test) group will receive an additional collagen matrix graft after the extraction, which will be sutured to the tooth socket. Sutures will be removed 1 week after surgery. Both groups will undergo CBCT imaging on the day of surgery and at the 3-month follow-up. Differences in bone measurements like height and width will be recorded as well as soft tissue measurements like thickness and width. Data acquired from two groups will be compared against each other to specify the protective effect of the applied collagen matrix graft.
To assess the clinical and volumetric efficacy of the porcine-derived collagen matrix during alveolar socket preservation is aimed in this study that is a randomized controlled clinical trial including two study groups. 24 participants with extraction indication in their non-molar teeth that are eligible will be recruited to the study according to the inclusion criteria of the trial. After the initial oral assessment, the participants were allocated into one of the groups via online randomizer software. Both groups will have the teeth extracted in an atraumatic way using dental periotomes to reduce the surgical trauma and unfavorable healing pattern. Control group sockets will heal spontaneously without any additional procedures. Test group sockets will be applied 8 mm circular collagen matrix grafts with 5/0 propylene sutures to secure the grafts in the sockets. The sutures will be removed at the 1-week follow-up. Both groups will be prescribed analgesic drugs and antimicrobial oral rinse. CBCT imaging will be performed right after surgery and at the 3-month follow-up. Volumetric measurements, like bone heights and widths, will be recorded in this period. Soft tissue changes will be recorded by oral examinations. Inter-group and intra-group differences will be assessed statistically.
167 studies on the registry are indexed under Bone Resorption; 28 are open to participants now.
This study's enrollment of 24 is close to the median of 24 across 146 interventional studies indexed under Bone Resorption.
Browse Bone Resorption studies →Altinbas University is the lead sponsor of 14 studies on the registry; 1 is open to participants now.
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Exclusion Criteria:
Systemically compromised patients Smokers Pregnancy or lactation Heavy periodontally compromised patients (Stage 3-4) Patients undergone radiotherapy in the last 2 years Collagen allergic patients Restorable teeth Overall plaque score and gingival score of >10%
The control group only went through routine tooth extractions without further interventions. Extraction sockets were left to spontaneous healing.
The test group received Collagen Matrix onto their extraction sockets after extractions.
Device: Collagen Matrix soft tissue graft
Circular 8 mm diameter collagen matrix grafts were sutured to seal extraction sockets in the participants. The sutures were removed 1 week after the intervention.
Buccal Height (BH)
Measurement of Buccal Height using CBCT scans
Time frame: From intervention day to 3 months follow-up
Buccal Width (BW)
Buccal Width measurements using CBCT scans
Time frame: From intervention day to 3-month follow-up
Palatal/lingual Height (PH)
Palatal/lingual height measuerements using CBCT scans
Time frame: From intervention day to 3-month follow-up
Palatal/lingual Width (PW)
Palatal/lingual width measurements using CBCT scans
Time frame: From intervention day to 3-month follow-up
Gingival Thickness (GT)
Gingival Thickness measurement using periodontal probe
Time frame: From intervention day to 3-month follow-up
Keratinized Tissue Width (KTW)
Keratinized Tissue Width measured using periodontal probe
Time frame: From intervention day to 3-month follow-up
PDFs hosted by the registry, ClinicalTrials.gov.
Plan to share: Undecided — IPD sharing may be available upon rasonable request
Started Jul 2025 (actual). Primary completion is estimated for Jan 2026, 6 months after the start.
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This study is active, not recruiting, as verified in Nov 2025. You cannot join it, but the record below documents what was studied.
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Altinbas University