ClinicalTrials.gg
RecruitingNCT06764654Updated Oct 9, 2026

Randomized Clinical Study Comparing Two Guided Surgery Techniques for Free-end Implant Placement

An interventional study of Dental implant placement in Dental Implant and Bone Resorption, sponsored by Aula Dental Avanzada. Recruiting at 2 sites in Spain. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-09.

Sponsored by Aula Dental Avanzada · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Started Jan 2025; still recruiting 1 year 10 months later.
Updated Oct 9, 2026Primary completion movedStudy completion moved+2 moreGo to Updates ↓
Phase
Not applicable
Study type
Interventional
Enrollment
40
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

This is a randomized multicenter clinical study that compares two static guided surgery techniques in free-end partial edentulism.

The aim is to compare the accuracy obtained between dento-osseous supported and dento-mucosal supported surgical splints to place dental implants in posterior osseous ridges.

Read the detailed description

Sample size increased from 20 to 40 participants (80 implants) via non-substantial amendment, acknowledged by the CEI Hospital Universitario Sant Joan d'Alacant (April 2026). Randomization and masking procedures unchanged.

02

Conditions studied

  • Dental Implant
  • Bone Resorption

Browse trials for

Keywords

  • dental implant
  • partial edentulous
  • guided surgery
03

In context

Bone Resorption

167 studies on the registry are indexed under Bone Resorption; 28 are open to participants now.

This study's planned enrollment of 40 is above the median of 24 across 146 interventional studies indexed under Bone Resorption.

Browse Bone Resorption studies →

Lead sponsor

Aula Dental Avanzada is the lead sponsor of 14 studies on the registry; 5 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Patients who present to one of the two participating clinics with a posterior edentulous area starting from the second premolar.
  • Patients in whom the placement of dental implants is not .

Exclusion criteria

Exclusion Criteria:

  • Patients with or allergies that contraindicate the intervention.
  • Presence of orofacial neurological symptoms.
  • Patients treated with bisphosphonates.
  • Pregnant or breastfeeding women, or women undergoing treatment.
  • Signs of infection in the surgical area.
  • Need for unconventional surgical procedures (e.g., split crest, vertical regeneration, block graft).
  • Lack of patient cooperation.
Terms in these criteria, in plain language(3)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Contraindication

A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.

Hypersensitivity

An allergy, or another reaction of the immune system, to a substance. “Hypersensitivity to the study drug” means a known allergic reaction to it — not every side effect a medicine can have.

Contraception

Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.

Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.

05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Care provider)
Enrollment
40 participants (estimated)

Study arms

  • Active comparator
    Tooth supported guide

    Patients who will receive implant placement using a tooth supported surgical guide.

    Procedure: Dental implant placement

  • Experimental
    Bone and tooth supported guide

    Patients who will receive implant placement using a bone and tooth supported surgical guide.

    Procedure: Dental implant placement

Interventions

  • ProcedureDental implant placement

    Placement of two dental implants in the jaw.

06

What researchers measure

Primary outcomes

  1. Three-dimensional implant position deviations (measured by intraoral scan and planning software)

    Three-dimensional deviations between the planned implant position and the actual postoperative implant position will be assessed. The deviations will be measured using an intraoral scanner (Medit i700®) and planning software (BlueSky Plan®). Units of measure: horizontal and vertical linear deviation (in millimeters), global deviation (in millimeters), and angular deviation (in degrees), evaluated at both implant entry and apex points.

    Time frame: From enrollment to the end of surgery

Secondary outcomes

  1. Three-dimensional implant position deviations (measured by CBCT and planning software)

    Three-dimensional deviations between the planned implant position and the actual postoperative implant position will be assessed. The deviations will be measured using cone-beam computed tomography (CBCT) and planning software (BlueSky Plan®). Units of measure: horizontal and vertical linear deviation (in millimeters), global deviation (in millimeters), and angular deviation (in degrees), evaluated at both implant entry and apex points.

    Time frame: From enrollment to the end of surgery

07

Study locations

2 of 2 sites recruiting
08

References and documents

Publications

  • Lin CC, Ishikawa M, Maida T, Cheng HC, Ou KL, Nezu T, Endo K. Stereolithographic Surgical Guide with a Combination of Tooth and Bone Support: Accuracy of Guided Implant Surgery in Distal Extension Situation. J Clin Med. 2020 Mar 5;9(3):709. doi: 10.3390/jcm9030709. PubMed 32151043 ↗
  • Liu R, Xia R, Zhang L, Gan X, Li C, Liu Q, Chen Z, Chen Z. The influence of guide stabilizers and their application sequences on trueness and precision of surgical guides in free end situations: An in vitro analysis. Clin Oral Implants Res. 2024 Mar;35(3):294-304. doi: 10.1111/clr.14226. Epub 2023 Dec 19. PubMed 38112164 ↗
  • Kessler A, Le V, Folwaczny M. Influence of the tooth position, guided sleeve height, supporting length, manufacturing methods, and resin E-modulus on the in vitro accuracy of surgical implant guides in a free-end situation. Clin Oral Implants Res. 2021 Sep;32(9):1097-1104. doi: 10.1111/clr.13804. Epub 2021 Jul 17. PubMed 34218450 ↗
  • Shi Y, Wang J, Ma C, Shen J, Dong X, Lin D. A systematic review of the accuracy of digital surgical guides for dental implantation. Int J Implant Dent. 2023 Oct 25;9(1):38. doi: 10.1186/s40729-023-00507-w. PubMed 37875645 ↗
  • Younes F, Cosyn J, De Bruyckere T, Cleymaet R, Bouckaert E, Eghbali A. A randomized controlled study on the accuracy of free-handed, pilot-drill guided and fully guided implant surgery in partially edentulous patients. J Clin Periodontol. 2018 Jun;45(6):721-732. doi: 10.1111/jcpe.12897. Epub 2018 May 10. PubMed 29608793 ↗
  • Cho JY, Kim SB, Ryu J. The accuracy of a partially guided system using an in-office 3D-printed surgical guide for implant placement. Int J Comput Dent. 2021 Feb 26;24(1):19-27. PubMed 34006060 ↗
  • Raico Gallardo YN, da Silva-Olivio IRT, Mukai E, Morimoto S, Sesma N, Cordaro L. Accuracy comparison of guided surgery for dental implants according to the tissue of support: a systematic review and meta-analysis. Clin Oral Implants Res. 2017 May;28(5):602-612. doi: 10.1111/clr.12841. Epub 2016 Apr 8. PubMed 27062555 ↗
  • Bover-Ramos F, Vina-Almunia J, Cervera-Ballester J, Penarrocha-Diago M, Garcia-Mira B. Accuracy of Implant Placement with Computer-Guided Surgery: A Systematic Review and Meta-Analysis Comparing Cadaver, Clinical, and In Vitro Studies. Int J Oral Maxillofac Implants. 2018 January/February;33(1):101-115. doi: 10.11607/jomi.5556. Epub 2017 Jun 20. PubMed 28632253 ↗

Individual participant data

Plan to share: No — Data available from the corresponding author upon reasonable request

09

Timeline

1 registry update since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedDate before it movedWhere the date was before it movedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Started Jan 2025 (actual). Primary completion is estimated for Jan 2027, 24 months after the start.

Of 82 non-industry interventional studies with no phase under Bone Resorption, half reached primary completion within 23 months of starting (the median), counting those still running; a quarter within 12 and three quarters within 35. This study's planned 24 months is close to that.

Counting every sponsor, half of 83 studies reached it within 23 months; a quarter within 12 and three quarters within 35.

Since we started tracking on Sep 25, 2026, the dates moved once, on Oct 9, 2026: primary completion Jan 2026 → Jan 2027 and completion Mar 2026 → Mar 2027.

Earlier changes are on the record history on ClinicalTrials.gov ↗

How these figures are worked out, and which studies are left out of them.

Registered
Jan 2, 2025
First posted
Jan 8, 2025
StartActual
Jan 1, 2025
Primary completionEst.
Jan 1, 2027was Jan 2026
CompletionEst.
Mar 1, 2027was Mar 2026
Last update
Oct 9, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
Primary completion
Jan 1, 2026→Jan 1, 2027
Oct 9, 2026
Study completion
Mar 1, 2026→Mar 1, 2027
Oct 9, 2026
Enrollment
20→40
Oct 9, 2026
Eligibility
Revised
Oct 9, 2026
Show all 1 update
  1. Oct 9, 2026
    Primary completion Jan 1, 2026→Jan 1, 2027
    Study completion Mar 1, 2026→Mar 1, 2027
    Enrollment 20→40
    Eligibility Revised
    + 5 other changes: verification date, description, conditions, references and data sharing statement

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT06764654
Lead sponsor
Aula Dental Avanzada
Collaborators
Mozo Grau Ticare
Responsible party
Jose Antonio Sánchez-Nicolás (Principal Investigator, Aula Dental Avanzada) — Principal investigator
First posted
Jan 8, 2025
Start date
Jan 1, 2025
Primary completion
Jan 1, 2027 (estimated)
Completion
Mar 1, 2027 (estimated)
Last update
Oct 9, 2026

Study contacts

Guillem Esteve-Pardo, PhD
Contact
guillem@clinicaesteve.es
+34 965215755

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Interested in this study?

Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.

Contact study team

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion