An interventional study of Vital pulp therapy and Extraction in Reversible Pulpitis and Irreversible Pulpitis, sponsored by Mansoura University. Completed at 1 site in Egypt. Open to participants aged 16 Years to 45 Years. Per ClinicalTrials.gov, last updated 2025-12-03.
Sponsored by Mansoura University · Not applicable, Interventional, and Treatment
intervention eligible patients with teeth diagnosed with reversible or irreversible pulpits will go for vital pulp therapy and the other group will be patients will go for extraction of caries free teeth for orthodontic reasons, blood samples will be collected from both groups to analyze the level of cytokines IL-8 and IL-10 and it's relation with the success of the pulp therapy
Mansoura University is the lead sponsor of 1,077 studies on the registry; 183 are open to participants now.
Of its 9 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
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Exclusion Criteria:
fifteen patients with carious teeth showing signs and symptoms of pulp inflammation
Procedure: Vital pulp therapy · Procedure: blood sample collection
fifteen patients with intact human premolars planed for extraction for orthodontic reason
Procedure: Extraction · Procedure: blood sample collection
1. Full medical and dental history will be taken from each patient. 2. Clinical and radiographic examination (Cone beam computed tomography) for the offending tooth. 3. After anesthesia, Rubber dam is applied and complete caries removal will be done, deeply inside the cavity, the excavation will be done using low speed hand piece and excavator. 4. A blood sample will be taken from the bleeding pulp tissue on a cotton pellet for Molecular test. 5. After exposure, the pulp will be amputated to the level of the canal orifices (full pulpotomy) pulp vitality was confirmed by the presence of bleeding pulp tissue from all canals. 6. Putty MTA will gently place over the pulp. 7. The cavity will be sealed with initial deep layer of resin modified glass ionomer restoration (RMGI) and final superficial layer of composite restoration.
1. Full medical and dental history will be taken from each patient. 2. Clinical and radiographic examination (Cone beam computed tomography) for the offending tooth. 3. After anesthesia, Rubber dam is applied. 4. A blood sample will be taken from the bleeding pulp tissue on a cotton pellet for Molecular test. 5. Extraction for orthodontic reasons.
after access opening blood sample will be collected
Clinical success
post operative pain on cold testing binary outcome (Yes or no)
Time frame: one day, one, four and twelve weeks.
Radiographic success
Cone Beam Computed Tomography CBCT radiographic Examination for any periodontal widening or any periapical radiolucency.
Time frame: Pre-operative , and after six months
level of cytokines
level of Interleukin 8 and Interleukin 10 will be measured using Enzyme- Linked Immunosorbent assay (ELISA) Kit
Time frame: through study completion, an average of 6 months
Plan to share: Undecided
No publications or documents are linked to this record.
This study is completed, as verified in Jul 2022. You cannot join it, but the record below documents what was studied.
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Mansoura University