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RecruitingNCT07248449DownSyndromeUpdated Nov 25, 2025

Physical Fitness in DS: A Comparison of Cuevas Medak and Rebound Exercises

An interventional study of Cuevas Medak Exercises in Down Syndrome, sponsored by Riphah International University. Recruiting at 1 site in Pakistan. Open to participants aged 3 Years to 8 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-11-25.

Sponsored by Riphah International University · Not applicable, Interventional, and Other

From the registry’s dates

  • Primary completion was expected by Jan 2026, 8 months ago, but the record still lists the study as recruiting.
  • Started Oct 2025; still recruiting 11 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
22
Allocation
Randomized
Ages
3 Years to 8 Years
Sex
All
01

Study summary

This randomized clinical trial investigates the comparative effects of Cuevas Medak Exercises Vs Rebound Exercises on physical fitness in DS. The.current study will be single blinded randomized clinical design in which nonprobability convenience sampling technique will be used. Inclusion criteria will be Down Syndrome. both genders will be included. The study involves 22 DS aged 3-8, will be assigned using lottery method, the participants will be randomly divided into two groups. One group will be given Cuevas Medek Exercises and the other with Rebound exercises. SAMU-Disability Fitness (DISFIT) battery will be used to assess the Physical Fitness in Down syndrome. Both groups will be given three treatment session per week for 12 weeks and total time for each session will be 30-45 minutes.

. Data will be analyzed through SPSS version 26.0

Read the detailed description

Down syndrome is usually associated with developmental delays, mild to moderate intellectual disability, and characteristic physical features. Children with DS usually encounter problems with the motor function as a result of decreased muscle tone, ligamentous laxity, decreased muscle strength, and endurance.

Children with DS experience decreased balance capacity on account of the brain stem and cerebellar hypoplasia leading to disruption of motor function and postural control. DS children have difficulty preserving their body posture which is frequently combined with an abnormality in gait pattern Cuevas Medek Exercises (CME) is a psychomotor therapy approach for rehabilitation programs that involves automatic motor reactions using exercises against gravity provoking the postural control and also describe its neuroplastic outcome. MEDEK is an acronym for a Spanish phrase means "Dynamic Method for Kinesthetic Stimulation infuriating postural control, which is not self-produced due to impaired central nervous system. The main mechanism is to generate new neuronal networks in affected central nervous system by utilizing scientific parameters associated to neuroplasticity (such as repetition, ROM, weight bearing, progression, significant exercises). Down syndrome might be particularly susceptible to loss of basic function because of poor physical fitness. Rebounding exercises are a series of movements based on trampoline exercises, have been used for children with different physical and intellectual disabilities. The Health Bounce, this is a basic movement that involves bouncing up and down on the trampoline.

Rebounding from quality mini trampoline provides all the benefits of other aerobic exercise without the stress impact .The objective of current study is to check the effects of Cuevas Medek exercise VS rebound exercise on physical fitness in children with Down syndrome . The current study will be single blinded randomized clinical design in which nonprobability convenience sampling technique will be used. Inclusion criteria will be Down Syndrome Age ranges between 3-8 yrs, both genders will be included, children who will be able to understand the commands given to them.

Exclusion Criteria will be Patients with medical condition, contracture, musculoskeletal disorders, Atlanta 3 CUEVAS MEDEK EXERCISES VS REBOUND EXERCISES IN DOWN SYNDROME -axial instability, uncorrected vision or orthopedic surgery. Using lottery method, the participants will be randomly divided in to two groups. One group will be given Cuevas Medek Exercises and the other with Rebound exercises. SAMU-Disability Fitness (DISFIT) battery will be used to assess the Physical Fitness in Down syndrome. Both groups will be given three treatment session per week for 12 weeks and total time for each session will be 30-45 minutes. Data will be analyzed by using SPSS v 26.Sample size is 24 and is calculated by epitool

02

Conditions studied

  • Down Syndrome

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Keywords

  • Cuevas Medek Exercise, Rebound Exercise, Down syndrome
03

In context

Down Syndrome

432 studies on the registry are indexed under Down Syndrome; 100 are open to participants now.

This study's planned enrollment of 22 is below the median of 36 across 283 interventional studies indexed under Down Syndrome.

Browse Down Syndrome studies →

Lead sponsor

Riphah International University is the lead sponsor of 2,133 studies on the registry; 633 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
3 Years to 8 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Children with Down syndrome
  • Age 3-8 years Both genders
  • Children who were able to understand the commands given to them.
  • They were able to stand and walk independently.

Exclusion criteria

Exclusion Criteria:

  • Patients with medical conditions that would severely limit their participation in the study
  • Hearing loss
  • Contracture
  • Musculoskeletal disorders,
  • Atlanto-axial instability
  • Cardiac anomalies
  • Thyroid abnormality
  • Seizures
  • Uncorrected vision problems
  • Orthopedic surgery or spasticity-reduction intervention
05

Study design

Phase
Not applicable
Primary purpose
Other
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Participant)
Enrollment
22 participants (estimated)

Study arms

  • Experimental
    Experimental:11 children of DS will be given Cuevas Medak Exercises for 12 weeks

    Baseline treatment will be applied to patient through following functional activities. Core strengthening exercises (isometrics) shall be given as a common treatment. This involved completing two sets of 15 repetitions with each repetition held for 5 seconds. The children in group 1 received Cuevas Medek exercise 3 times per week for 3 successive months. The patient was supported at board at the leg level with slight posterior support to maintain balance. After being lifted off the ground for a few seconds, gentle up and down oscillations were applied. The study utilized three wooden boxes with identical dimensions measuring 20cm x 40cm x 60cm each, along with a larger box, a wooden plate, and two planks of equal size measuring 17cm x 80cm. These items were arranged in various configurations to create structures such as slides, piano flaps, and stairs.

    Other: Cuevas Medak Exercises

  • Experimental
    Expermental:11 children of DS will be given Rebound Exercises for 15 min

    Group b will receive Rebound exercise. Baseline treatment will be applied to patient. The children in group 2 received rebounding exercise 3 times per week for 3 successive months. Mini trampoline.Each rebounding session consisted of the following schedule: (3 min of rebounding) - (3 min rest) - (3 min of rebounding) - (3 min rest) - (3 min of rebounding). Thus, one treatment session corresponded to 9 min of rebounding exercise (21). side sitting and high kneeling); bouncing and / or being bounced without leaving the surface of the trampoline.

    Other: Cuevas Medak Exercises

Interventions

  • OtherCuevas Medak Exercises

    Group A 11 children of DS will be given Cuevas Medak Exercises for 12 weeks and total time for each session will be 30-45 min. Group B 11 children of DS will be given Rebound Exercises for 15 min though this can be broken into multiple 3-5 min

    Also known as: Rebound Exercises

06

What researchers measure

Primary outcomes

  1. SAMU-DISFITT Battery for Physical fitness

    The SAMU-DISFIT battery is a reliable and feasible physical fitness battery which has been created with the purpose of establishing tests which measure the four basic components of PF (flexibility, cardiorespiratory fitness, musculoskeletal fitness and motor fitness) in DS. physical fitness (PF) of child with DS: Body Mass Index (BMI), Waist Circumference

    Time frame: Baseline,12 weeks

07

Study locations

1 of 1 sites recruiting
  • Muhammad Nouman Ashraf
    Lahore, Punjab Province 54000, Pakistan
    Recruiting
08

References and documents

Publications

  • Cabeza-Ruiz R, Alcantara-Cordero FJ, Ruiz-Gavilan I, Sanchez-Lopez AM. Feasibility and Reliability of a Physical Fitness Test Battery in Individuals with Down Syndrome. Int J Environ Res Public Health. 2019 Jul 27;16(15):2685. doi: 10.3390/ijerph16152685. PubMed 31357594 ↗

Individual participant data

Plan to share: No

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 25, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07248449
Lead sponsor
Riphah International University
Responsible party
Sponsor
First posted
Nov 25, 2025
Start date
Oct 22, 2025
Primary completion
Jan 30, 2026 (estimated)
Completion
Jan 30, 2026 (estimated)
Last update
Nov 25, 2025

Study contacts

IMRAN, PhD AMJAD, PHD
Contact
imran.amjad@riphah.edu.pk
9233224390125
Muhammad Asif Javed, MS-PT
Contact
a.javed@riphah.edu.pk
923224209422
Ayesha Afzal, MS-PT
principal investigator · Riphah International University

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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