An observational study in Obesity, Inflammation and Bariatric Surgery Candidate, sponsored by Adana City Training and Research Hospital. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2026-08-27.
Sponsored by Adana City Training and Research Hospital · Observational
This retrospective observational study aimed to compare the effects of low-flow and standard-flow sevoflurane anesthesia on perioperative inflammatory responses in patients undergoing laparoscopic sleeve gastrectomy for obesity. Data were obtained from the anesthesia and laboratory records of 155 adult patients who received either low-flow (1 L/min) or standard-flow (4 L/min) sevoflurane anesthesia between January 2022 and January 2025 at Adana City Training and Research Hospital. Preoperative and postoperative inflammatory markers, including C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), and red cell distribution width (RDW), were recorded and compared between the two groups. Hemodynamic parameters such as mean arterial pressure and heart rate were also analyzed to assess intraoperative stability. The primary objective of the study was to evaluate the impact of anesthetic flow rate on perioperative inflammation, while the secondary objective was to assess hemodynamic stability during anesthesia. This study may contribute to a better understanding of how low-flow anesthesia influences systemic inflammatory responses and perioperative hemodynamics in morbidly obese patients undergoing bariatric surgery.
This retrospective observational cohort study investigated the effects of low-flow and standard-flow sevoflurane anesthesia on perioperative inflammatory markers and hemodynamic stability in patients with obesity undergoing laparoscopic sleeve gastrectomy. The study included 155 adult patients operated between January 2022 and January 2025 at Adana City Training and Research Hospital, Adana, Turkey.
Patients were divided into two groups according to the fresh-gas flow rate used during anesthesia:
Low-flow group: sevoflurane with a total fresh-gas flow rate of 1 L/min,
Standard-flow group: sevoflurane with a total fresh-gas flow rate of 4 L/min.
All patients received general anesthesia as part of routine clinical care. No randomization or intervention was performed by the investigators. Demographic characteristics, anesthesia records, intraoperative hemodynamic parameters (mean arterial pressure, heart rate), and perioperative laboratory results were obtained retrospectively from hospital electronic records.
Preoperative and postoperative (24-hour) values of inflammatory markers-including C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), and red cell distribution width (RDW)-were compared within and between groups. The primary endpoint was the change in these inflammatory biomarkers between pre- and postoperative measurements. The secondary endpoint was the comparison of intraoperative hemodynamic stability (MAP and HR variability, incidence of hypotension or bradycardia) between the two groups.
This study aims to provide evidence regarding whether low-flow sevoflurane anesthesia (1 L/min) offers comparable or superior inflammatory and hemodynamic profiles compared with standard-flow anesthesia (4 L/min) in morbidly obese patients. The findings may help optimize anesthetic techniques for bariatric surgery by balancing patient safety, hemodynamic stability, and environmental considerations.
6,296 studies on the registry are indexed under Obesity; 1,692 are open to participants now.
This study's enrollment of 155 is above the median of 135 across 1,283 observational studies indexed under Obesity.
Browse Obesity studies →Adana City Training and Research Hospital is the lead sponsor of 17 studies on the registry; 1 is open to participants now.
Counted across the registry records on this site, refreshed daily.
Retrospective analysis of 155 adult patients who underwent laparoscopic sleeve gastrectomy under general anesthesia between January 2022 and January 2025 at Adana City Training and Research Hospital. Patients were grouped according to the fresh gas flow rate used during anesthesia (low-flow vs. standard-flow sevoflurane).
Exclusion Criteria:
Patients who underwent laparoscopic sleeve gastrectomy under general anesthesia with low-flow sevoflurane (fresh gas flow = 1 L/min). Data were obtained retrospectively from hospital records.
Patients who underwent laparoscopic sleeve gastrectomy under general anesthesia with standard-flow sevoflurane (fresh gas flow = 4 L/min). Data were obtained retrospectively from hospital records.
Change in C-reactive protein (CRP) concentration
Change in serum C-reactive protein (CRP) levels from preoperative baseline to postoperative 24 hours will be compared between low-flow and standard-flow sevoflurane groups.
Time frame: From preoperative baseline to postoperative 24 hours
Change in neutrophil-to-lymphocyte ratio (NLR)
Change in neutrophil-to-lymphocyte ratio (NLR) from preoperative baseline to postoperative 24 hours will be compared between low-flow and standard-flow sevoflurane groups.
Time frame: From preoperative baseline to postoperative 24 hours
Change in red cell distribution width (RDW)
Change in red cell distribution width (RDW) from preoperative baseline to postoperative 24 hours will be compared between low-flow and standard-flow sevoflurane groups.
Time frame: From preoperative baseline to postoperative 24 hours
Mean arterial pressure (MAP) variability
Change and variability in intraoperative mean arterial pressure (MAP) recorded throughout anesthesia will be compared between low-flow and standard-flow sevoflurane groups.
Time frame: From induction of anesthesia to end of anesthesia
Heart rate (HR) variability
Change and variability in intraoperative heart rate (HR) recorded throughout anesthesia will be compared between low-flow and standard-flow sevoflurane groups.
Time frame: From induction of anesthesia to end of anesthesia
Plan to share: No — The datasets generated and analyzed during the current study are not publicly available due to institutional data protection policies.
No publications or documents are linked to this record.
This study is completed, as verified in Nov 2025. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Adana City Training and Research Hospital