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CompletedNCT07421180AdropinUpdated Feb 20, 2026

Maternal Serum Adropin in Placenta Accreta Spectrum

An observational study in Placenta Accreta Spectrum and Placenta Previa, sponsored by Adana City Training and Research Hospital. Completed at 1 site in Turkey (Türkiye). Open to female participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-02-20.

Sponsored by Adana City Training and Research Hospital · Observational

Study type
Observational
Model
Case-control
Time perspective
Cross-sectional
Enrollment
84
Ages
18 Years to 45 Years
Sex
Female
01

Study summary

Aim: To compare maternal serum adropin levels in pregnancies complicated by placenta previa and/or placenta accreta spectrum (PAS) with those of healthy pregnant women and to evaluate the diagnostic value of adropin for predicting placental invasion.

Methods:

This cross-sectional study included 84 singleton pregnancies at ≥34 weeks of gestation: 42 women diagnosed with placenta previa and/or PAS and 42 healthy pregnant women who underwent cesarean delivery. Maternal serum adropin levels are measured preoperatively using enzyme-linked immunosorbent assay. Demographic, obstetric, ultrasonographic, and intraoperative findings were recorded. Receiver operating characteristic (ROC) curve analysis is performed to assess the predictive performance of adropin for PAS.

02

Conditions studied

  • Placenta Accreta Spectrum
  • Placenta Previa

Keywords

  • Placenta accreta spectrum
  • Placenta previa
  • Adropin
  • Endothelial dysfunction
  • Biomarker
03

In context

Placenta Accreta

150 studies on the registry are indexed under Placenta Accreta; 40 are open to participants now.

This study's enrollment of 84 is close to the median of 87 across 78 observational studies indexed under Placenta Accreta.

Browse Placenta Accreta studies →

Lead sponsor

Adana City Training and Research Hospital is the lead sponsor of 17 studies on the registry; 1 is open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 45 Years
Sexes eligible
Female
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

Pregnant women aged 18-45 years in the reproductive period with singleton, viable third-trimester pregnancies diagnosed with placenta previa and/or PAS were included in the study. The control group consisted of healthy pregnant women in the third trimester with similar demographic characteristics who underwent elective cesarean delivery and had no obstetric or medical comorbidities.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Pregnant women aged 18-45 years in the reproductive period
  • Singleton, viable third-trimester pregnancies diagnosed with placenta previa and/or PAS

Exclusion criteria

Exclusion Criteria:

  • Uterine anomalies,
  • Chronic systemic diseases,
  • Multiple pregnancies,
  • Obstetric complications such as preterm premature rupture of membranes, threatened preterm labor, fetuses followed for intrauterine growth restriction, and placental abruption.
05

Study design

Observational model
Case-control
Time perspective
Cross-sectional
Enrollment
84 participants (actual)
Patient registry
No
Biospecimen retention
Samples without dna

Groups and cohorts

  • Study group (Diagnosed with Plasenta Previa and/or Placenta accreta spectrum)

    Pregnant women aged 18-45 years viable third-trimester pregnancies diagnosed with placenta previa and/or PAS (Placenta accreta spectrum)

  • control group

    healthy pregnant women in the third trimester with similar demographic characteristics

06

What researchers measure

Primary outcomes

  1. Blood serum Adropin levels

    The aim of the present study was to evaluate maternal serum adropin levels in pregnancies complicated by placenta previa and placenta accreta spectrum and compare to healthy controls.

    Time frame: From 15.04.2024 to 01.04.2025

07

Study locations

1 site
  • University of Heath and Science Adana City Hospital
    Adana, Yuregir 01100, Turkey (Türkiye)
08

References and documents

Individual participant data

Plan to share: No — Demographical values could be shared. The questionaries answers are personal so only scale results may be shown.

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 20, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07421180
Lead sponsor
Adana City Training and Research Hospital
Responsible party
Gulsum Uysal (Professor Gulsum Uysal, Adana City Training and Research Hospital) — Principal investigator
First posted
Feb 19, 2026
Start date
May 15, 2024
Primary completion
Apr 1, 2025
Completion
Apr 1, 2025
Last update
Feb 20, 2026

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Feb 2026. You cannot join it, but the record below documents what was studied.

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