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CompletedNCT07261449Updated May 4, 2026

Effectiveness of Low-intensity Laser on Pain in Patients With Supraspinatus Tendinopathy.

An interventional study of Placebo Group and Laser Group in Tendinopathy, sponsored by Universidad Pontificia de Salamanca. Completed at 1 site in Spain. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-05-04.

Sponsored by Universidad Pontificia de Salamanca · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Registered 2 years 2 months after the study started (first participant enrolled Sep 2023, registered Nov 2025).
Phase
Not applicable
Study type
Interventional
Enrollment
40
Allocation
Randomized
Ages
18 Years to 65 Years
Sex
All
01

Study summary

Tendinopathy is an inflammatory process that occurs in and around the tendon when both are affected by a certain injury. In the case of the supraspinatus muscle it is one of the most frequent causes of shoulder pain. To test the efficacy of laser treatment in reducing shoulder pain caused by supraspinatus muscle tendinopathy. A randomized controlled clinical trial (RCT) was carried out in which a physiotherapy intervention was performed using therapeutic laser for three months, to observe the influence on the pain generated by supraspinatus muscle tendinopathy in the shoulder.

02

Conditions studied

  • Tendinopathy

Keywords

  • pain
  • range of motion
  • quality of life
03

In context

Tendinopathy

413 studies on the registry are indexed under Tendinopathy; 64 are open to participants now.

This study's enrollment of 40 is below the median of 50 across 339 interventional studies indexed under Tendinopathy.

Browse Tendinopathy studies →

Lead sponsor

Universidad Pontificia de Salamanca is the lead sponsor of 9 studies on the registry; 2 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Score of 3 or higher on the VAS scale for the shoulder.
  • Adequate cognitive ability for comprehension.
  • Rotator cuff tendinopathy confirmed by ultrasound at the study center, either due to tendon inflammation, presence of hypoechoic areas, calcification, fibrillar disorganization, and/or neovascularization in the supraspinatus muscle.
  • Pain in the proximal lateral part of the arm that worsens with abduction.

Exclusion criteria

Exclusion Criteria:

  • Contraindications specific to laser treatment (e.g., tumors, presence of pacemaker or defibrillator, pregnancy, etc.).
  • History of glenohumeral fracture and rheumatoid arthritis.
  • Rheumatic, neurological, or structural polymyalgia affecting the joint.
  • Previous surgeries.
  • Pregnant or breastfeeding women.
  • Taking anticoagulants or antiplatelet agents.
  • Diabetes mellitus.
  • Cardiac dysfunction.
  • Infiltrative and/or rehabilitative treatment in the two months prior to recruitment.
  • Pre-existing conditions associated with pain in the upper extremities. Difficulties with follow-up.
  • Depression.
  • Treatment with another intervention; during the study, they will not be able to undergo it.
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Triple (Participant, Investigator, Outcomes assessor)
Enrollment
40 participants (actual)

Study arms

  • Experimental
    Laser treatment

    Laser treatment on tendinophaty shoulder.

    Device: Laser Group

  • Placebo comparator
    Placebo Group

    Placebo treatment on tendinophaty shoulder.

    Device: Placebo Group

Interventions

  • DevicePlacebo Group

    A placebo treatment is carried out on the shoulder, simulating the application of the laser.

  • DeviceLaser Group

    Therapeutic laser treatment is performed on the shoulder.

06

What researchers measure

Primary outcomes

  1. intensity of pain.

    measured using the VAS scale, where 0 is the least possible pain and 10 is the greatest possible pain

    Time frame: 3 months

Secondary outcomes

  1. Range of motion

    Shoulder mobility in the joint ranges of flexion, extension, abduction, adduction, and external and internal rotation. Measurement in degrees using a goniometer.

    Time frame: 3 months

  2. Patient quality of life

    DASH questionnaire The score ranges from 0, which is equivalent to having no disability, to a maximum of 100, which is equivalent to having a very severe functional limitation.

    Time frame: 3 months

07

Study locations

1 site
  • Universidad Pontificia de Salamanca
    Salamanca, 37002, Spain
08

References and documents

Publications

  • Redondo-Alonso L, Chamorro-Moriana G, Jimenez-Rejano JJ, Lopez-Tarrida P, Ridao-Fernandez C. Relationship between chronic pathologies of the supraspinatus tendon and the long head of the biceps tendon: systematic review. BMC Musculoskelet Disord. 2014 Nov 18;15:377. doi: 10.1186/1471-2474-15-377. PubMed 25408141 ↗
  • Haik MN, Alburquerque-Sendin F, Moreira RF, Pires ED, Camargo PR. Effectiveness of physical therapy treatment of clearly defined subacromial pain: a systematic review of randomised controlled trials. Br J Sports Med. 2016 Sep;50(18):1124-34. doi: 10.1136/bjsports-2015-095771. Epub 2016 Jun 10. PubMed 27288517 ↗
  • Romero-Morales C, Bravo-Aguilar M, Abuin-Porras V, Almazan-Polo J, Calvo-Lobo C, Martinez-Jimenez EM, Lopez-Lopez D, Navarro-Flores E. Current advances and novel research on minimal invasive techniques for musculoskeletal disorders. Dis Mon. 2021 Oct;67(10):101210. doi: 10.1016/j.disamonth.2021.101210. Epub 2021 Jun 4. PubMed 34099238 ↗
  • Asensio-Olea L, Leiros-Rodriguez R, Marques-Sanchez MP, de Carvalho FO, Maciel LYS. Efficacy of percutaneous electrolysis for the treatment of tendinopathies: A systematic review and meta-analysis. Clin Rehabil. 2023 Jun;37(6):747-759. doi: 10.1177/02692155221144272. Epub 2022 Dec 30. PubMed 36583575 ↗
  • Sanchez-Sanchez JL, Calderon-Diez L, Herrero-Turrion J, Mendez-Sanchez R, Arias-Buria JL, Fernandez-de-Las-Penas C. Changes in Gene Expression Associated with Collagen Regeneration and Remodeling of Extracellular Matrix after Percutaneous Electrolysis on Collagenase-Induced Achilles Tendinopathy in an Experimental Animal Model: A Pilot Study. J Clin Med. 2020 Oct 15;9(10):3316. doi: 10.3390/jcm9103316. PubMed 33076550 ↗

Individual participant data

Plan to share: Yes — De-identified individual participant data, including the data dictionary, will be shared with qualified researchers. The shared IPD will include the data needed to reproduce the study findings, such as the de-identified participant-level data underlying the results reported in the publication.

Supporting information: Study protocol, Icf

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 4, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07261449
Lead sponsor
Universidad Pontificia de Salamanca
Responsible party
Jorge Velazquez (Principal Investigator, Universidad Pontificia de Salamanca) — Principal investigator
First posted
Dec 3, 2025
Start date
Sep 12, 2023
Primary completion
Jul 24, 2024
Completion
Jun 12, 2025
Last update
May 4, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Apr 2026. You cannot join it, but the record below documents what was studied.

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