An interventional study of Early space closure and Delayed space closure in Gingival Cleft and Orthodontic Space Closure, sponsored by Bahria University. Recruiting at 1 site in Pakistan. Per ClinicalTrials.gov, last updated 2025-10-07.
Sponsored by Bahria University · Not applicable, Interventional, and Treatment
The goal of this split-mouth randomized controlled trial is to assess whether the timing of extraction space closure-early vs. delayed initiation-affects the incidence of gingival cleft development in orthodontic patients. The main question it aims to answer is:
Does the incidence of gingival cleft development get influenced by the specific time point at which orthodontic space closure is initiated following extraction?
Quadrants will be assigned to the early movement group and the other to the delayed movement group and extractions will be performed accordingly. These will be assessed for the effect on development of gingival cleft development.
88 studies on the registry are indexed under Gingival Diseases; 23 are open to participants now.
This study's planned enrollment of 19 is below the median of 46 across 69 interventional studies indexed under Gingival Diseases.
Browse Gingival Diseases studies →Bahria University is the lead sponsor of 36 studies on the registry; 11 are open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Canine retraction will be started 1 week after extraction
Other: Early space closure
Canine retraction will be started 8 weeks after extraction
Other: Delayed space closure
Space closure will be started 1 week after extraction
Space closure will be started 8 weeks after extraction
presence of gingival clefts after space closure initiation
The primary outcome will be the presence of gingival clefts, which will be measured at 3 months and 6 months after space closure initiation
Time frame: start of canine retraction to its completion (approximately 6 months)
craniofacial growth pattern
craniofacial growth pattern from sum of posterior angles
Time frame: craniofacial growth pattern will be measured at baseline
gingival biotype
gingival biotype by measuring thickness of gingiva using spreader of size 15
Time frame: At baseline (immediately prior to tooth extraction)
buccal bone dehiscence
bone dehiscence will be measured utilizing the periodontal probe(in mm) from the distal marginal ridge of premolar as reference point, on both the buccal and palatal/lingual side.
Time frame: Immediately post extraction
canine bulbosity
Maximum height of contour of canine will be measured on the pretreatment cast using the digital vernier caliper
Time frame: will be measured at baseline
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
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Bahria University