An interventional study of Optical imaging of the tissues in Cornea, Skin Diseases and Gingival Diseases, sponsored by Massachusetts General Hospital. Recruiting at 1 site in United States. Open to participants aged 18 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-13.
Sponsored by Massachusetts General Hospital · Not applicable, Interventional, and Basic science
The overall goal of this study is to develop OCT Vibrography (aka OCT elastography) as a novel tool for measuring biomechanical properties of human tissues in vivo.
The overall goal of this study is to develop OCT Vibrography (aka OCT elastography) as a novel tool for measuring biomechanical properties of human tissues in vivo. The investigators aim to establish baseline data in healthy subjects, compare elastic moduli in different tissue types, and measure differences in elastic moduli between keratoconus and normal eyes. If successful, this project will provide useful, previously inaccessible elastic parameters and advance the investigators' understanding of the relationship between the bulk mechanical properties and the microstructure of the human tissue in vivo. This information can ultimately be used to improve the diagnosis and treatment of keratoconus, inflammatory skin diseases, and inflammatory gingiva diseases. More broadly, the technologies developed in this project will have relevance to other potential applications beyond the tissues in this research study.
219 studies on the registry are indexed under Corneal Diseases; 43 are open to participants now.
This study's planned enrollment of 90 is above the median of 40 across 132 interventional studies indexed under Corneal Diseases.
Browse Corneal Diseases studies →Massachusetts General Hospital is the lead sponsor of 2,586 studies on the registry; 447 are open to participants now.
Of its 222 completed or terminated interventional studies of FDA-regulated products, 168 (76%) have results posted.
Counted across the registry records on this site, refreshed daily.
Group 1:
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Group 2:
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Group 4:
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Optical imaging of the cornea in healthy subjects
Device: Optical imaging of the tissues
Optical imaging of the skin in healthy subjects
Device: Optical imaging of the tissues
Optical imaging of the gingiva in healthy subjects
Device: Optical imaging of the tissues
Optical imaging of the cornea in mild and moderate keratoconus
Device: Optical imaging of the tissues
OCT vibrography
Number of subjects to successfully complete OCT Vibrography without serious unanticipated adverse events related to application of the device.
Frequency and severity of all treatment-related adverse events
Time frame: 1 year
Plan to share: No
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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