ClinicalTrials.gg
RecruitingNCT07202754Updated Jul 9, 2026

Procedural Complications and Long-Term Mortality in Complex Coronary Interventions

An observational study in Complex Coronary Artery Disease, sponsored by Istanbul Mehmet Akif Ersoy Educational and Training Hospital. Recruiting at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 85 Years. Per ClinicalTrials.gov, last updated 2026-07-09.

Sponsored by Istanbul Mehmet Akif Ersoy Educational and Training Hospital · Observational

From the registry’s dates

  • Started May 2026; still recruiting 5 months later.
Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
20,000
Ages
18 Years to 85 Years
Sex
All
01

Study summary

The relative risks for different non-fatal intraprocedural complications during complex percutaneous coronary intervention (PCI) on subsequent mortality have not been described. This study aimed to assess the association between non-fatal intraprocedural complications and late mortality after complex coronary PCI.

Read the detailed description

Complex coronary lesions include chronic total occlusion, osteal epicardial lesions, long (diffuse) coronary disease, severe calcific lesions, true bifurcation disease, left main coronary lesion, lesions with severe thrombus, and in-stent restenosis. Non-fatal intraprocedural complications included abrupt occlusion, worsening of thrombolysis in myocardial infarction (TIMI) flow grade (TIMI \< 3), major dissection (greater than type B), occurrence of thrombus formation, perforation of the main vessel or side branch, malignant arrhythmias, stroke/transient ischemic attack, and non-coronary major bleeding.

02

Conditions studied

  • Complex Coronary Artery Disease

Keywords

  • Complications, death, major adverse cardiac events, target vessel revascularization
03

In context

Death

456 studies on the registry are indexed under Death; 86 are open to participants now.

This study's planned enrollment of 20,000 is above the median of 400 across 236 observational studies indexed under Death.

Browse Death studies →

Lead sponsor

Istanbul Mehmet Akif Ersoy Educational and Training Hospital is the lead sponsor of 11 studies on the registry; 7 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 85 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Complex coronary lesions include chronic total occlusion, osteal epicardial lesions, long (diffuse) coronary disease, severe calcific lesions, true bifurcation disease, left main coronary lesion, lesions with severe thrombus, and in-stent restenosis.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Patients with complex coronary disease
  • Aged 18-85 years

Exclusion criteria

Exclusion Criteria:

  • Patients diagnosed with cardiogenic shock
  • Coronary lesions with non-complex features
  • Percutaneous coronary intervention with a bare metal stent
  • Patient \<1 year
  • Known relevant allergies
  • Absence of all medical records
  • Patients with early discontinuation of dual antiplatelet therapy
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Life expectancy

The study doctor’s estimate of how long someone is likely to live. Criteria use it so that people can stay in the study long enough for it to answer its question.

05

Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
20,000 participants (estimated)
Patient registry
No

Groups and cohorts

  • Group 1

    Non-fatal complications (+)

  • Group 2

    Non-fatal complications (-)

06

What researchers measure

Primary outcomes

  1. Death

    All cause death

    Time frame: up to 60 months

07

Study locations

1 of 1 sites recruiting
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 9, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07202754
Lead sponsor
Istanbul Mehmet Akif Ersoy Educational and Training Hospital
Collaborators
Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul Training and Research Hospital, Sisli Hamidiye Etfal Training and Research Hospital, Bagcilar Training and Research Hospital, Ankara Etlik City Hospital, Ankara Bilkent Sehir Hastanesi, Bursa City Hospital, Ege University, Kocaeli University, Trakya University, Van Training and Research Hospital, Cigli Regional Training Hospital, Istanbul University - Cerrahpasa, University of Yalova, Bursa Yuksek Ihtisas Training and Research Hospital
Responsible party
Ahmet Guner (Principal Investigator, Istanbul Mehmet Akif Ersoy Educational and Training Hospital) — Principal investigator
First posted
Oct 2, 2025
Start date
May 13, 2026
Primary completion
Jul 7, 2026
Completion
Jul 7, 2026 (estimated)
Last update
Jul 9, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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No contact was published for this record. The registry link below has the sponsor’s details.

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