An observational study in Coronary Arterial Disease (CAD), Percutaneous Coronary Intervention (PCI) and Bifurcation Coronary Disease, sponsored by Istanbul Mehmet Akif Ersoy Educational and Training Hospital. Recruiting at 2 sites in Turkey. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-04-17.
Sponsored by Istanbul Mehmet Akif Ersoy Educational and Training Hospital · Observational
The Crush technique for coronary bifurcation lesions has evolved significantly since its introduction to the literature by Colombo et al. in 2003, with several iterations, including double kissing balloon inflation. The main disadvantage of the historical Crush technique is the low success rate of the final kissing balloon inflation. An improvement came with the introduction of double kissing crush stenting aiming for the shorter protrusion and kissing balloon dilation performed before and after main branch stent implantation. The double kissing crush provides a significant reduction in major adverse cardiovascular events compared to Provisional stenting, Crush, and Culotte techniques. Recently, a novel modified mini-crush technique (controlled balloon-crush) has been introduced to the literature and is one of the most up-to-date crush techniques. The main advantage of this technique over the contemporary mini-crush technique is that the side branch can be easily rewired, and the 1:1 size non-compliant balloon can easily pass through the crushed stent structure in the ostial part of the side branch. The basic rationale of this is that the crushing of the side branch stent is done in a more controlled manner (by slowly deflation of the side branch stent balloon), and this causes less disruption of the stent cells. To date, no data compares the mid-term outcomes of double kissing crush and controlled balloon-crush stenting techniques in patients with complex coronary bifurcation lesions. Hence, this study aimed to determine the clinical results of double kissing crush and controlled balloon-crush techniques under mid-term follow-up.
2,839 studies on the registry are indexed under Coronary Disease; 311 are open to participants now.
This study's planned enrollment of 300 is below the median of 460 across 953 observational studies indexed under Coronary Disease.
Browse Coronary Disease studies →Istanbul Mehmet Akif Ersoy Educational and Training Hospital is the lead sponsor of 11 studies on the registry; 7 are open to participants now.
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Complex coronary bifurcation disease
Exclusion Criteria:
Primary endpoint (Target lesion failure)
Target lesion failure (%) is defined as the combination of cardiac death (%), target vessel myocardial infarction (%), or target lesion revascularization (%) rates.
Time frame: 36 months
Plan to share: Undecided
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Istanbul Mehmet Akif Ersoy Educational and Training Hospital