CClinicalTrials.gg
CompletedNCT07197151Updated Sep 29, 2025

CYFIP1 and PKM2 Synergistically Regulate ROS and Glycolysis in Colorectal Cancer Through the AKT/mTOR/HIF-1α Cascad

An observational study in Colorectal Cancer (CRC) and Specimens Are to be Collected From Subjects Who Are Having or Have Had a Fluid or Tissue Removed, a Biopsy or a Blood or Bone Marrow Draw, sponsored by hui hou. Completed at 1 site in China. Per ClinicalTrials.gov, last updated 2025-09-29.

Sponsored by hui hou · Observational

Study type
Observational
Model
Other
Time perspective
Other
Enrollment
32
Sex
All
01

Study summary

Collect some tumor tissue specimens from patients who have undergone colorectal cancer surgery and conduct experiments such as immunohistochemistry to observe the expression of related genes in colorectal cancer.

Read the detailed description

We need to collect postoperative specimens and adjacent normal tissue specimens from patients with colorectal cancer for immunohistochemical staining. There is no need to conduct any other grouping of the patients.

02

Conditions studied

  • Colorectal Cancer (CRC)
  • Specimens Are to be Collected From Subjects Who Are Having or Have Had a Fluid or Tissue Removed, a Biopsy or a Blood or Bone Marrow Draw
03

In context

Colorectal Neoplasms

5,599 studies on the registry are indexed under Colorectal Neoplasms; 1,459 are open to participants now.

This study's enrollment of 32 is below the median of 250 across 1,226 observational studies indexed under Colorectal Neoplasms.

Browse Colorectal Neoplasms studies →

Lead sponsor

hui hou is the lead sponsor of 3 studies on the registry; 1 is open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients with colorectal cancer who have undergone surgical treatment

Eligibility criteria

Inclusion Criteria:(1) Patients diagnosed with colorectal cancer who received surgical treatment and postoperative chemotherapy (2) Patients who were conscious of their condition and voluntarily participated (3) No other serious underlying diseases

Exclusion Criteria:(1) Concurrent other serious chronic diseases or organ damage (2) Diagnosed with benign colorectal tumors

05

Study design

Observational model
Other
Time perspective
Other
Enrollment
32 participants (actual)
Target follow-up
1 Year
Patient registry
Yes
Biospecimen retention
Samples with dna

Interventions

  • OtherPerform surgery on patients with colorectal cancer and collect cancer and adjacent tissue specimens

    Perform surgery on patients with colorectal cancer and collect cancer and adjacent tissue specimens

06

What researchers measure

Primary outcomes

  1. Immunohistochemical determination of the expression levels of related genes

    Time frame: 2022.09-2025.09

07

Study locations

1 site
  • The Second Affiliated Hospital of Anhui Medical University
    Hefei, Anhui 230032, China
08

References and documents

Study documents

  • Study protocol · Sep 19, 2025

Documents are hosted by the registry — open the source record to download them.

Individual participant data

Plan to share: No — The collected information includes the patient's personal details. It will still be needed for further experiments and cannot be shared for the time being.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 29, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07197151
Lead sponsor
hui hou
Responsible party
hui hou (Chief Physician, The Second Hospital of Anhui Medical University) — Sponsor-investigator
First posted
Sep 29, 2025
Start date
Aug 1, 2022
Primary completion
Sep 1, 2025
Completion
Sep 1, 2025
Last update
Sep 29, 2025

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Sep 2025. You cannot join it, but the record below documents what was studied.

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