An interventional study of Laparoscopic liver resection and Open liver resection in Laparoscopic Liver Resection and Open Liver Resection, sponsored by hui hou. Not yet recruiting at 1 site in China. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2018-12-13.
Sponsored by hui hou · Not applicable, Interventional, and Treatment
LLR was applied for tumors located at the lower edge and lateral segments of the liver that could be resected more easily than posterosuperior segments. With the development of technology and the growing experience of hepatobiliary surgeons, LLR has been expanded to major liver resections, anatomical resections, and donor hepatectomies by skilled surgeons. However, due to the concerns over the risk of operative bleeding, tumor seeding and positive resection margin, the true benefit of LLR remains unclear across surgical community.
The 2nd International Consensus Conference on Laparoscopic Liver Resection (ICCLLR) was held in Morioka, Japan, in 2014. The new recommendations of the ICCLLR state that the outcomes of LLR are not inferior than OLR regarding to operative mortality rate and margin negativity, and are superior in decreasing postoperative complications, blood loss, and the length of the postoperative hospital stay. However, it is not clear that whether LLR is able to alleviate the impairment of liver function after hepatic resection, and there is no RCTs to compare the short and long outcomes between LLR and OLR.
hui hou is the lead sponsor of 3 studies on the registry; 1 is open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Laparoscopic hepatectomy
Procedure: Laparoscopic liver resection
Open hepatectomy
Procedure: Open liver resection
Laparoscopic hepatectomy
Traditional open hepatectomy
Change of serum glutamic oxalacetic transaminase
Change of serum glutamic oxalacetic transaminase after liver resection.These values will be recorded preoperative, and postoperative day-1,3,5,7.
Time frame: up to 7 days after liver resection
Change of serum glutamic-pyruvic transaminase
Change of serum glutamic-pyruvic transaminase after liver resection.These values will be recorded preoperative, and postoperative day-1,3,5,7.
Time frame: up to 7 days after liver resection
Postoperative complication(Rates in different grades)
According to The Clavien-Dindo Classification, https://www.assessurgery.com/clavien-dindo-classification/
Time frame: up to 30 days after liver resection
Mortality rates
the rate of postoperative death
Time frame: up to 30 days after liver resection
Hospital duration after operation (days)
the length of hospital stay
Time frame: up to 30 days after liver resection
Operation time(min)
the during of operation
Time frame: up to 30 days after liver resection
Blood loss(ml)
the volume of blood loss
Time frame: up to 30 days after liver resection
Blood transfusion (times and units)
intraoperative blood transfusion
Time frame: intraoperative
Duration of nasogastric tubes (hours)
Duration of nasogastric tubes
Time frame: up to 14 days after liver resection7
Duration of abdominal drain (days)
Duration of abdominal drain
Time frame: up to 14 days after liver resection
Duration to first flatus (days)
Duration to first flatus
Time frame: up to 14 days after liver resection
Comfort questionnaire measures (GCQ) measures by Kolcaba
GCQ measures by Kolcaba, download from http://www.thecomfortline.com/resources/cq.html.
Time frame: up to 7 days after liver resection
Resection margin status
the R0 resection rate
Time frame: up to 30 days after liver resection
Intensive care unit stay (days)
Intensive care unit stay in days
Time frame: up to 7 days after liver resection
Readmission rate
measure the rate of readmission
Time frame: up to 30 days after liver resection
C-reactive protein (mg/mL)
C-reactive protein levels on preoperative and postoperative day-1,3,5
Time frame: up to 5 days after liver resection
Disease recurrence rates
The disease recurrence after operation
Time frame: up to 5 years
Overall survival time (month)
Overall survival time after operation
Time frame: up to 5 years after operation
Disease free survival time (month)
Disease free survival time after operation
Time frame: up to 5 years after operation
Plan to share: No
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This study is not yet recruiting, as verified in Dec 2018. You cannot join it, but the record below documents what was studied.
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