A Phase 2 interventional study of Lactobacillus plantarum and inactivated Lactobacillus plantarum in Psoriasis and Lactobacillus Plantarum, sponsored by Shenzhen People's Hospital. Recruiting at 1 site in China. Open to participants aged 16 Years to 60 Years. Per ClinicalTrials.gov, last updated 2025-12-24.
Sponsored by Shenzhen People's Hospital · Phase 2, Interventional, and Treatment
A growing body of evidence indicates that the pathogenesis of psoriasis may be closely linked to skin microbiome dysbiosis. Compared with healthy individuals, the composition and function of the skin microbiota in psoriasis patients exhibit significant alterations5,6. This microbial imbalance is thought to contribute to the initiation and progression of the disease through mechanisms such as triggering abnormal immune responses, exacerbating inflammatory processes, and impairing the skin barrier.
In-depth exploration of the interplay between psoriasis and the microbiome not only offers new perspectives for elucidating the disease's pathogenesis but also lays the groundwork for developing innovative microbiota-targeted diagnostic and therapeutic strategies. Thus, identifying novel therapeutic approaches that bridge psoriasis treatment and microbial regulation holds substantial clinical and social value.
While existing treatments for psoriasis have made some progress, research specifically focusing on the microbiota-psoriasis relationship remains relatively limited. Investigating the intrinsic connections between microecological balance and psoriasis management, and developing practical improvement strategies, is therefore of crucial practical significance for enhancing skin health and improving quality of life. This study aims to address this research gap and provide a new therapeutic option for individuals with psoriasis.
2,028 studies on the registry are indexed under Psoriasis; 275 are open to participants now.
This study's planned enrollment of 184 is above the median of 75 across 1,565 interventional studies indexed under Psoriasis.
Browse Psoriasis studies →Shenzhen People's Hospital is the lead sponsor of 63 studies on the registry; 7 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Intervention measures for the experimental group: Apply 5ml of Lactobacillus plantarum solution extracted from the skin surface of healthy individuals to the psoriatic lesions daily, for a duration of 2 months.
Biological: Lactobacillus plantarum
Intervention measures for the control group: Apply 5ml of inactivated Lactobacillus plantarum solution to the psoriatic lesions daily, for a duration of 2 months.
Biological: inactivated Lactobacillus plantarum
Intervention measures for the experimental group: Apply 5ml of Lactobacillus plantarum solution extracted from the skin surface of healthy individuals to the psoriatic lesions daily, for a duration of 2 months.
Intervention measures for the control group: Apply 5ml of inactivated Lactobacillus plantarum solution to the psoriatic lesions daily, for a duration of 2 months.
Transepidermal Water Loss(TEWL)
Use a dermatological detector to measure the TEWL of the skin. Gently press the probe against the subject's skin, and the TEWL at that location will be displayed on the device's screen.
Time frame: The follow-up periods are set at 1, 2, 4, and 8 weeks after the initial treatment.
General appearance photography
After shooting, three professional doctors will independently assess the improvement of psoriatic lesions in patients.
Time frame: The follow-up periods are set at 1, 2, 4, and 8 weeks after the initial treatment.
Dermoscopic photography
After shooting, three professional doctors will independently assess the improvement of psoriatic lesions in patients.
Time frame: The follow-up periods are set at 1, 2, 4, and 8 weeks after the initial treatment.
Completion of self-assessment questionnaires
Record the improvement of patients' self-perceived suboptimal skin conditions after treatment compared with the baseline.
Time frame: The follow-up periods are set at 1, 2, 4, and 8 weeks after the initial treatment.
Adverse reactions
Subjects will record predefined expected post-treatment events at the treated sites.
Time frame: The follow-up periods are set at 1, 2, 4, and 8 weeks after the initial treatment.
Plan to share: No
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Studies of the drug tested here: Lactobacillus plantarum
Shenzhen People's Hospital