An observational study in Intensive Care Unit Acquired Weakness and Intensive Care Unit (ICU) Acquired Weakness (ICU - AW), sponsored by Universidade Federal do Rio de Janeiro. Recruiting at 1 site in Brazil. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-09-25.
Sponsored by Universidade Federal do Rio de Janeiro · Observational
This longitudinal, prospective observational study aims to evaluate functional status in critically ill adult patients in the Intensive Care Unit using the Chelsea Critical Care Physical Assessment Tool (CPAx). The primary objective is to analyze CPAx score variation as a potential predictor of clinical outcomes, including mortality and duration of mechanical ventilation. Functional assessments will be performed at intensive care unit (ICU) admission and discharge to monitor changes in physical function and to predict adverse clinical outcomes.
This prospective, longitudinal, and observational study will be conducted at the general ICU of Pedro Ernesto University Hospital (HUPE). Demographic and clinical information at admission will be collected, including age, sex, type of airway at ICU admission, cause of ICU admission, comorbidities, and clinical scores such as Sepsis-related Organ Failure Assessment (SOFA), Simplified Acute Physiology Score III (SAPS III), and Charlson Comorbidity Index. During the ICU stay, data on the use of invasive mechanical ventilation, non-invasive ventilation, high-flow nasal cannula (HFNC), renal replacement therapy, extubation, and reintubation will be recorded. The CPAx will be assessed at ICU admission and discharge. Additionally, total hospital and ICU length of stay, as well as days on mechanical ventilation, will be recorded.The study aims to analyze the variation in CPAx scores as a predictor of adverse clinical outcomes, including mortality and duration of mechanical ventilation.
477 studies on the registry are indexed under Muscle Weakness; 73 are open to participants now.
This study's planned enrollment of 186 is above the median of 68 across 108 observational studies indexed under Muscle Weakness.
Browse Muscle Weakness studies →Universidade Federal do Rio de Janeiro is the lead sponsor of 123 studies on the registry; 11 are open to participants now.
Counted across the registry records on this site, refreshed daily.
The general ICU admits both surgical patients and clinical patients, including those with acute illnesses or decompensations of chronic diseases. Participants include both male and female patients.
Inclusion Criteria: All adult patients admitted to the Pedro Ernesto University Hospital (HUPE) General ICU over 18 years of age and with an ICU stay greater than or equal to 48 hours will be included.
Exclusion Criteria:
Adult patients admitted to the general ICU at Pedro Ernesto University Hospital (HUPE) who were discharged from the ICU to the hospital ward.
Adult patients admitted to the general ICU at Pedro Ernesto University Hospital (HUPE) who died during their ICU stay.
hospital mortality
Mortality will be collected during the period of hospitalization
Time frame: 12 months
mechanical ventilation days
It will be collected from the date of intubation in the intensive care unit until the date of extubation or up to 48 hours off mechanical ventilation in cases of tracheostomized patients and/or until the outcome of death
Time frame: 6 months
ICU length of stay
It will be collected from the date of intensive care unit admission until the outcome of discharge from the intensive care unit or death.
Time frame: 6 months
length of hospital
It will be collected from the date of intensive care unit admission until the outcome of hospital discharge or death.
Time frame: 12 months
Extubation rate
Proportion of patients who were extubated during ICU stay.
Time frame: 30 days
Reintubation rate
Proportion of patients who require reintubation after extubation during ICU stay.
Time frame: 30 days
Plan to share: No
No publications or documents are linked to this record.
Started Jan 2025 (actual). Primary completion is estimated for Jul 2026, 18 months after the start.
Of 48 non-industry observational studies under Muscle Weakness, half reached primary completion within 25 months of starting (the median), counting those still running; a quarter within 12 and three quarters within 63. This study's planned 18 months is below that.
Counting every sponsor, half of 50 studies reached it within 26 months; a quarter within 12 and three quarters within 63.
How these figures are worked out, and which studies are left out of them.
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