An interventional study of Blood flow restriction training with 60%-80% occlusion and Standard postoperative knee rehabilitation with sham BFRT in Knee Arthroscopic Surgery, Arthrogenic Muscle Inhibition and Quadriceps Muscle Weakness, sponsored by Yuxiu Ji. Recruiting at 1 site in China. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2026-10-28.
Sponsored by Yuxiu Ji · Not applicable, Interventional, and Treatment
Arthrogenic muscle inhibition (AMI) is the key neurophysiological cause of impeding quadriceps activation following anterior cruciate ligament reconstruction (ACLR). Blood flow restriction training (BFRT) may induce neuroplasticity whereas the neurophysiological responses remain uncertain. In this study, we aimed to explore the effects of constant pressure blood flow restriction training (CP-BFRT) on neurophysiological responses and physical function. Patients will receive the same standardized progressive physical rehabilitation for 2 weeks after the surgery and then start the BRFT or sham BRFT intervention for the following 12 weeks.
477 studies on the registry are indexed under Muscle Weakness; 73 are open to participants now.
This study's planned enrollment of 56 is above the median of 44 across 362 interventional studies indexed under Muscle Weakness.
Browse Muscle Weakness studies →This is the only study on the registry with Yuxiu Ji as lead sponsor.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
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Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Progressive BFRT exercises with 60%-80% of arterial occlusion pressure. The BFRT protocol was individualized based on limb circumference and tolerance, with pressure settings determined using the limb occlusion pressure method. For lower extremity training, pressure was set at 60%-80% of arterial occlusion pressure (approximately 140-220 mmHg depending on individual limb characteristics).
Other: Blood flow restriction training with 60%-80% occlusion
Participants in CON group with sham BFRT completed 3 sets of 10 repetitions for each exercise with the sham unit set to 20 mmHg. The restriction pressure was based on prior work which shows that 20 mmHg is well below the threshold for either arterial or venous occlusion.
Other: Standard postoperative knee rehabilitation with sham BFRT
A personalized constant-pressure system served as the active BFRT unit, with restrictive pressure set at 60%-80% of limb arterial occlusion pressure; it auto-inflates to maintain constant pressure and automatically monitors, assesses, and adjusts pressure during training.
Also known as: KAATSU Training, Occlusion Training
Standard postoperative rehabilitation protocol after knee arthroscopic surgery, without blood flow restriction training. The rehabilitation program includes range of motion exercises, muscle strength training, balance training and functional activity training, with the same schedule, frequency and duration as the experimental group.
H-reflex Hmax/Mmax Ratio
H-reflex is a validated neurophysiological indicator for evaluating spinal-level AMI after knee surgery which is applied to assess resting spinal reflex excitability of the knee extensor motor pool vastus medialis. Unit of Measure: Ratio (dimensionless)
Time frame: From enrollment to the end of treatment at 12 weeks.
Knee Joint Position Sense (JPS) Accuracy
Knee proprioceptive acuity was evaluated using a calibrated isokinetic dynamometer. Participants were blindfolded to exclude visual interference and seated with the tested lower limb securely strapped to the dynamometer lever arm. The knee was passively positioned at three target flexion angles (30°, 60°, and 90°). After passive positioning and a 3-second holding phase, participants actively reproduced the perceived target angle independently. Absolute angular error was calculated as the absolute discrepancy between the preset target angle and the actively reproduced angle. Unit of Measure: Degrees (°)
Time frame: From enrollment to the end of treatment at 12 weeks.
Somatosensory Evoked Potential (SEP) P40 Latency
Cortical somatosensory afferent function was assessed via tibial nerve somatosensory evoked potentials (SEP). The P40 latency was defined as the time interval from stimulus onset to the occurrence of the P40 positive wave, representing the conduction efficiency and temporal characteristics of peripheral proprioceptive signals transmitting to the primary somatosensory cortex. Unit of Measure: Milliseconds (ms)
Time frame: From enrollment to the end of treatment at 12 weeks.
Somatosensory Evoked Potential (SEP) N45-P40 Peak-to-peak Amplitude
Central sensory integration plasticity was assessed via tibial nerve somatosensory evoked potentials (SEP). The N45-P40 peak-to-peak amplitude was calculated to evaluate cortical sensory gain and central inhibitory/excitatory balance. Unit of Measure: Microvolts (μV)
Time frame: From enrollment to the end of treatment at 12 weeks.
Quadriceps rapid torque development rate (RTD)
Quadriceps rapid torque development rate (RTD) was measured to quantify the efficiency of central motor unit recruitment and neuromuscular rapid-driving capability. Quadriceps RTD was calculated as the rate of torque increase within the early contraction phase, reflecting the recruitment efficacy of high-threshold type II muscle fibers and synchronous firing of motor units. Unit of Measure: Nm/s
Time frame: From enrollment to the end of treatment at 12 weeks.
Plan to share: No
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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