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Not yet recruitingNCT07184580EITICUUpdated Sep 22, 2025

Electrical Impendance Tomography Usage in ICU

An observational study in ARDS, Alveolar Recruitment Manoeuvres and Prone Position, sponsored by Erasme University Hospital. Not yet recruiting. Open to participants aged 12 Years and older. Per ClinicalTrials.gov, last updated 2025-09-22.

Sponsored by Erasme University Hospital · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
1,000
Ages
12 Years and older
Sex
All
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Study summary

Electrical Impedance Tomography (EIT) is a non-invasive, radiation-free, bedside imaging technique that has been in clinical use for over three decades (1).

It is primarily utilized to monitor regional lung ventilation in mechanically ventilated patients. In recent years, EIT has become a routine tool in critical care settings due to its capacity to provide real-time, bedside insights into pulmonary function. Its applications are diverse, ranging from support during non-invasive ventilation and endotracheal intubation (2) to the management of complex cases of mechanical ventilation. One of its key advantages lies in guiding the optimization of Positive End-Expiratory Pressure (PEEP) titration, which may help tailor ventilatory support to individual patients and potentially reduce the mechanical power delivered to the lungs(3,4).

Despite these benefits, current evidence does not conclusively demonstrate a reduction in mortality associated with the use of EIT in critical care (5,6). Nevertheless, EIT shows promise in several emerging areas, such as monitoring ventilation distribution during prone positioning - even in awake, non-intubated patients (7) - and in the early detection of atelectasis under various clinical conditions (8).

Recently, advancements in EIT technology have led to the development of new models capable of assessing pulmonary "pulsatility," thereby expanding the potential clinical applications of EIT beyond traditional ventilation monitoring. This feature may facilitate the bedside detection of conditions such as atelectasis, pneumonia, pleural effusion, and even pulmonary embolism (9,10).

In this context, the Intensive Care Unit at Erasme Hospital is acquiring two EIT devices to enhance diagnostic capabilities and improve the care of patients requiring either non-invasive or invasive ventilation during their ICU stay. To support the systematic implementation of these devices and enable future research, it is necessary to establish a registry documenting their clinical use within the ICU. This registry will serve as a foundation for tracking usage patterns, evaluating outcomes, and potentially contributing to future scientific studies.

Standard ICU data such as SOFA scores and SAPS II will be recorded, as is already routinely done in some registries like Epimed.

This registry will be specific to the Erasme ICU and will collect detailed data on ventilation parameters, EIT measurements, and recruitment maneuvers in patients undergoing mechanical ventilation-whether invasive or non-invasive-when the clinical team determines that a recruitment maneuver is indicated and chooses to use an EIT device for monitoring.

Data will be entered into RedCap by the attending physicians or physiotherapists responsible for the patient.

Data collection will be prospective, as it is not technically possible to automatically synchronize the recording of ventilation parameters and EIT measurements using the existing software systems.

There are no expected risks for the patients, as the procedures involved are considered standard practice in intensive care settings.

Patients may benefit from the collection of these data, as it allows for closer monitoring of ventilation parameters during their ICU stay.

As this is a registry-based study, there will be no predefined duration or fixed number of patients. However, we estimate data will be recorded over a five-year period, with an inclusion of at least 300 patients per year.

Inclusion Criteria for ICU Patients:

  • Patient aged more than 12 years old (no pediatric EIT belt)
  • Patient monitored by an EIT belt OR Patient undergoing a recruitment maneuver OR Patient undergoing prone position.
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Conditions studied

  • ARDS
  • Alveolar Recruitment Manoeuvres
  • Prone Position
  • Electrical Impedance Tomography (EIT)

Keywords

  • ARDS
  • Recruitment manoeuvres
  • Prone positioning
  • PEEP optimization
  • EIT
  • Electrical impedance tomography
03

In context

Lead sponsor

Erasme University Hospital is the lead sponsor of 178 studies on the registry; 34 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
12 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

All critical care patients for whom clinicians estimated the need for EIT measurements could be included, except pediatric patients under 12 years of age, as the belt used for this device is not designed for children.

Eligibility criteria

Inclusion Criteria for ICU Patients:

  • Patient aged more than 12 years old (no pediatric EIT belt)
  • Patient monitored by an EIT belt

Exclusion criteria Patient who expressed opposition to participate.

05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
1,000 participants (estimated)
Target follow-up
2 Months
Patient registry
Yes

Groups and cohorts

  • Mechanically ventilated patients

    Mechanically ventilated patients for which an EIT belt has been placed, for PEEP optimization, ventilation monitoring, prone positioning evaluation,...

  • Non-invasive ventilation patients

    Patients included in the study who are only on

06

What researchers measure

Primary outcomes

  1. Mortality rate

    Assessment of mortality

    Time frame: up to 30 days

Secondary outcomes

  1. PaO2/FiO2 ratio

    Measurement on PaO2/FiO2 before and after the usage of EIT

    Time frame: During the measurement using the EIT in the ICU

  2. Hospital mortality rate

    Hospital mortality

    Time frame: Through hospital discharge (average of 14 days)

  3. Ventilation free days

    Number of days without ventilation for patients who are mechanically ventilated

    Time frame: 28 days since the start of ventilation

  4. Mechanical power

    Measurement on mechanical power before and after the usage of EIT

    Time frame: During the measurement using the EIT in the ICU

07

Study locations

No study locations are listed for this record.

08

References and documents

Publications

  • Beitler JR, Sarge T, Banner-Goodspeed VM, Gong MN, Cook D, Novack V, Loring SH, Talmor D; EPVent-2 Study Group. Effect of Titrating Positive End-Expiratory Pressure (PEEP) With an Esophageal Pressure-Guided Strategy vs an Empirical High PEEP-Fio2 Strategy on Death and Days Free From Mechanical Ventilation Among Patients With Acute Respiratory Distress Syndrome: A Randomized Clinical Trial. JAMA. 2019 Mar 5;321(9):846-857. doi: 10.1001/jama.2019.0555. PubMed 30776290 ↗
  • He H, Chi Y, Yang Y, Yuan S, Long Y, Zhao P, Frerichs I, Fu F, Moller K, Zhao Z. Early individualized positive end-expiratory pressure guided by electrical impedance tomography in acute respiratory distress syndrome: a randomized controlled clinical trial. Crit Care. 2021 Jun 30;25(1):230. doi: 10.1186/s13054-021-03645-y. PubMed 34193224 ↗
  • Songsangvorn N, Xu Y, Lu C, Rotstein O, Brochard L, Slutsky AS, Burns KEA, Zhang H. Electrical impedance tomography-guided positive end-expiratory pressure titration in ARDS: a systematic review and meta-analysis. Intensive Care Med. 2024 May;50(5):617-631. doi: 10.1007/s00134-024-07362-2. Epub 2024 Mar 21. PubMed 38512400 ↗
  • Jimenez JV, Munroe E, Weirauch AJ, Fiorino K, Culter CA, Nelson K, Labaki WW, Choi PJ, Co I, Standiford TJ, Prescott HC, Hyzy RC. Electric impedance tomography-guided PEEP titration reduces mechanical power in ARDS: a randomized crossover pilot trial. Crit Care. 2023 Jan 17;27(1):21. doi: 10.1186/s13054-023-04315-x. PubMed 36650593 ↗
  • Kim Y, Webster JG, Tompkins WJ. Electrical impedance imaging of the thorax. J Microw Power. 1983 Sep;18(3):245-57. doi: 10.1080/16070658.1983.11689329. PubMed 6558130 ↗

Individual participant data

Plan to share: Undecided

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 22, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07184580
Lead sponsor
Erasme University Hospital
Responsible party
Charles Dehout (Medical doctor, intensivist, principal investigator, Erasme University Hospital) — Principal investigator
First posted
Sep 22, 2025
Start date
Oct 15, 2025 (estimated)
Primary completion
Oct 2030 (estimated)
Completion
Apr 2031 (estimated)
Last update
Sep 22, 2025

Study contacts

Charles Dehout, M.D
Contact
charles.dehout@hubruxelles.be
+ 32 2 555 6589
Mouna Mohib, M.D.
Contact
mouna.mohib@hubruxelles.be
+ 32 2 555 2779

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Sep 2025. You cannot join it, but the record below documents what was studied.

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