An observational study in ACS (Acute Coronary Syndrome) and Young Adults, sponsored by China-Japan Friendship Hospital. Not yet recruiting. Open to participants aged 18 Years to 45 Years. Per ClinicalTrials.gov, last updated 2025-08-19.
Sponsored by China-Japan Friendship Hospital · Observational
The incidence of acute myocardial infarction (AMI) in young patients is on the rise, placing a heavy health and economic burden on individuals, families, and society. The clinical phenotype and pathophysiological mechanisms of AMI in this population exhibit significant heterogeneity compared to elderly patients, and existing risk assessment tools have limited applicability in this specific group. The core problem this study aims to address is: how to accurately identify specific risk factors in young AMI patients and build an effective risk prediction model to prevent and optimize clinical diagnosis and treatment.
This study will adopt a prospective cohort design to collect multi-dimensional clinical data from young AMI patients. It will systematically analyze their clinical characteristics, risk factors, and coronary lesion status to comprehensively map the clinical, risk factor, and pathophysiological diversity of young AMI patients. Secondly, it will delve into identifying specific risk factors that influence the onset, progression, and long-term prognosis of young AMI. Thirdly, it will combine machine learning algorithms to develop a risk prediction model for young AMI, performing internal validation in the prospective cohort and external validation in the MIMIC-IV database. Simultaneously, it will explore novel biomarkers associated with disease onset and progression. The key outcomes of this study are to establish a high-quality clinical database of young AMI patients, design a risk prediction model for young AMI based on the study results, and produce high-level academic publications.
1,461 studies on the registry are indexed under Acute Coronary Syndrome; 267 are open to participants now.
This study's planned enrollment of 200 is below the median of 500 across 561 observational studies indexed under Acute Coronary Syndrome.
Browse Acute Coronary Syndrome studies →China-Japan Friendship Hospital is the lead sponsor of 173 studies on the registry; 109 are open to participants now.
Counted across the registry records on this site, refreshed daily.
The study population for this project primarily consists of patients aged 18 to 45 years (inclusive) with acute myocardial infarction (AMI). These patients meet the diagnostic criteria for either ST-elevation myocardial infarction (STEMI) or non-ST-elevation myocardial infarction (NSTEMI) and presented for medical attention within 24 hours of symptom onset.
Exclusion Criteria:
Malignant arrhythmia events
Time frame: Short-term endpoints (in-hospital and within 30 days post-discharge).Long-term endpoints (12 months post-discharge).
All-cause mortality
Time frame: Short-term endpoints (in-hospital and within 30 days post-discharge).Long-term endpoints (12 months post-discharge).
Non-fatal myocardial infarction
Time frame: Short-term endpoints (in-hospital and within 30 days post-discharge).Long-term endpoints (12 months post-discharge).
No study locations are listed for this record.
Plan to share: No
No publications or documents are linked to this record.
This study is not yet recruiting, as verified in Aug 2025. You cannot join it, but the record below documents what was studied.
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China-Japan Friendship Hospital