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CompletedNCT07122934PC-CBSUpdated Aug 14, 2025

Posterior Circulation Clot Burden Score (Pc-CBS) Predicts Clinical Outcome After Acute Ischemic Stroke Related to Posterior Circulation Occlusions : An Externally Validated Radiological Score

An observational study in Acute Ischemic Stroke, Posterior Circulation Brain Infarction and Arterial Occlusion Disease, sponsored by Centre Hospitalier Universitaire Vaudois. Completed. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-08-14.

Sponsored by Centre Hospitalier Universitaire Vaudois · Observational

Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
1,828
Ages
18 Years and older
Sex
All
01

Study summary

Posterior circulation strokes (PCS) represent \~30% of all ischemic strokes, but existing prognostic tools are limited, especially for non-basilar artery occlusions. Accurate early outcome prediction may aid treatment decisions and clinical trial design. We developed and externally validated the Posterior Circulation Clot Burden Score (PC-CBS), a radiological tool to predict 3-month functional outcome in acute ischemic stroke due to posterior circulation occlusion.

02

Conditions studied

  • Acute Ischemic Stroke
  • Posterior Circulation Brain Infarction
  • Arterial Occlusion Disease
03

In context

Ischemic Stroke

2,612 studies on the registry are indexed under Ischemic Stroke; 971 are open to participants now.

This study's enrollment of 1,828 is above the median of 300 across 771 observational studies indexed under Ischemic Stroke.

Browse Ischemic Stroke studies →

Lead sponsor

Centre Hospitalier Universitaire Vaudois is the lead sponsor of 208 studies on the registry; 48 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients suffering from an acute ischemic stroke (AIS) clinically and/or radiologically attributable to a posterior circulation arterial occlusion

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • age >18 years old
  • admitted within 24h from last known well
  • symptomatic arterial occlusion. The following arterial occlusions were eligible for inclusion: the extracranial vertebral artery between the V0 and V3 segments; the intracranial portion of the vertebral artery; the basilar artery either in its proximal, mid and/or distal segment, the P1 and/or the P2 segments of the posterior cerebral artery.

Exclusion criteria

Exclusion Criteria:

  • simultaneous clinical and/or radiological strokes in the posterior and anterior circulation
05

Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
1,828 participants (actual)
Patient registry
No

Groups and cohorts

  • Development and Internal validation cohort

    Diagnostic Test: Assessment of cervico-cerebral arterial occlusion pattern

  • External validation cohort

    Diagnostic Test: Assessment of cervico-cerebral arterial occlusion pattern

Interventions

  • Diagnostic testAssessment of cervico-cerebral arterial occlusion pattern

    Assessment of cervico-cerebral arterial occlusion pattern for the development of a radiological score

06

What researchers measure

Primary outcomes

  1. Modified rankin scale at three months

    Time frame: 3 months

07

Study locations

No study locations are listed for this record.

08

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Ran from Feb 2003 to primary completion in Mar 2023, 241 months.

How these figures are worked out, and which studies are left out of them.

Registered
Aug 8, 2025
First posted
Aug 14, 2025
StartActual
Feb 1, 2003
Primary completionActual
Mar 31, 2023
CompletionActual
Aug 8, 2025
Last update
Aug 14, 2025
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Aug 14, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07122934
Collaborators
Insel Gruppe AG, University Hospital Bern, Hospital de Egas Moniz, University Hospital Heidelberg, IRCCS Istituto delle Scienze Neurologiche di Bologna, The University of Texas Health Science Center, Houston, Azienda Ospedaliero-Universitaria di Modena, Hospital Vall d'Hebron, Boston University, Università degli Studi di Brescia, Medical University of Graz, Hôpital Rothschild, Medical University of Vienna, Hebrew University of Jerusalem, Michigan State University, Medical University Innsbruck, Ludwig-Maximilians - University of Munich, Ospedale Policlinico San Martino, EOC Lugano CH, University Hospital, Basel, Switzerland, Aristotle University Of Thessaloniki, Technische Universität Dresden
Responsible party
Dr. med. Alexander Salerno, MD-PhD (Senior registrar, Centre Hospitalier Universitaire Vaudois) — Principal investigator
First posted
Aug 14, 2025
Start date
Feb 1, 2003
Primary completion
Mar 31, 2023
Completion
Aug 8, 2025
Last update
Aug 14, 2025

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Aug 2025. You cannot join it, but the record below documents what was studied.

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