An interventional study of Low meal condition and Moderate meal condition in SCI - Spinal Cord Injury, sponsored by University of Miami. Recruiting at 1 site in United States. Open to participants aged 18 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-30.
Sponsored by University of Miami · Not applicable, Interventional, and Basic science
The purpose of this research is to determine the effects of food on cardiovascular and metabolic health in men with and without spinal cord injury (SCI).
SCI and Controls
SCI Only
Exclusion Criteria:
SCI and Controls
SCI Only
Subjects will be in this group for up to 3 weeks.
Other: Low meal condition · Other: Ad-libitum control condition
Subjects will be in this group for up to 3 weeks.
Other: Moderate meal condition · Other: Ad-libitum control condition
Subjects will be in this group for up to 3 weeks.
Other: High meal condition · Other: Ad-libitum control condition
Participants will consume a standardized meal (500 grams) with a low nutrient modification one time at one visit. Participants will attend one visit per week for 3 weeks. Each is visit separated by one week and each visit will take approximately 6 hours
Participants will consume a standardized meal (500 grams) with a moderate nutrient modification one time at one visit. Participants will attend one visit per week for 3 weeks. Each is visit separated by one week and each visit will take approximately 6 hours.
Participants will consume a standardized meal (500 grams) with a high nutrient modification one time at one visit. Participants will attend one visit per week for 3 weeks. Each is visit separated by one week and each visit will take approximately 6 hours.
The ad-libitum meal consists of 600-700 g of a standardized control meal one time at all visits. Participants will attend one visit per week for 3 weeks. Each visit is separated by one week and each visit will take approximately 6 hours.
Diet induced thermogenesis (DIT)
Diet-induced thermogenesis (DIT) will be measured using indirect calorimetry. A portable mask-based metabolic system, which will measure expired air to calculate dietary-induced thermogenesis defined as the energy expended above resting and the proportion of meal energy expended postprandially (postprandial kilocalorie (kcal) expended/total meal kcal) where a higher value means more energy is expended.
Time frame: up to 3 weeks (collected during each of the intervention visits)
Hunger Series Visual Analog Scale
Satiety will be measured using the Hunger Series Visual Analog Scale (HSVAS), which assesses subjective appetite. Each scale is defined at 0 as "not at all hungry" and 100 as "totally/a lot/very hungry". A sum score will be calculated.
Time frame: up to 3 weeks (collected during each of the intervention visits)
Post ad-libitum energy intake measured in grams
This value will be expressed as a ratio of energy consumed to energy requirements (energy intake/energy requirements x 100) and will be recorded in grams.
Time frame: up to 3 weeks (collected during each of the intervention visits)
Plan to share: No
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University of Miami