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CompletedNCT07086430Updated Jul 25, 2025

Independent Effects of Visceral Adipose Volume and Density on Patient Survival in Peritoneal Dialysis

An observational study in Uremia and End Stage Renal Disease on Dialysis, sponsored by RenJi Hospital. Completed. Per ClinicalTrials.gov, last updated 2025-07-25.

Sponsored by RenJi Hospital · Observational

Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
358
Sex
All
01

Study summary

It was VAT volume predict patient outcome, while VAT density predicted baseline membrane function in PD patients and reflected peritoneal vascular density and local inflammation status.

02

Conditions studied

  • Uremia
  • End Stage Renal Disease on Dialysis

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Keywords

  • peritoneal dialysis
  • fat attenuation index on CT
03

In context

Uremia

53 studies on the registry are indexed under Uremia; 10 are open to participants now.

This study's enrollment of 358 is above the median of 105 across 12 observational studies indexed under Uremia.

Browse Uremia studies →

Lead sponsor

RenJi Hospital is the lead sponsor of 550 studies on the registry; 247 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

The study included peritoneal dialysis patients follow up in our center who had an abdominal CT scan within 2 weeks before PD catheter incubation. Those with acute inflammation according to clinical signs, lab results or abdominal CT scan were excluded from the cohort. In early years, abdominal CT scan was done if the patient reported history of abdominal abnormalities, such as history of cholelithiasis. Since 2020 it became a routine check before PD catheter incubation in our center. Those with cholelithiasis or hernia were suggested to had the preventive operation at the time of PD catheter incubation under general anesthesia. The patients started PD within 4 weeks after catheter incubation. A validation cohort was from a satellite center of the hospital. The inclusion criteria were same as the derivation cohort.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • The study included peritoneal dialysis patients follow up in our center who had an abdominal CT scan within 2 weeks before PD catheter incubation.

Exclusion criteria

Exclusion Criteria:

  • Those with acute inflammation according to clinical signs, lab results or abdominal CT scan were excluded from the cohort.
05

Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
358 participants (actual)
Patient registry
No

Groups and cohorts

  • derivation cohort; validation cohort
06

What researchers measure

Primary outcomes

  1. To evaluate the association between peritoneal membrane solute transfer rate and abdominal visceral adipose tissue density measured on CT

    Time frame: from the baseline, 4 weeks before PD catheter insert surgery until patients quit PD or follow up up to 48 months

07

Study locations

No study locations are listed for this record.

08

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Ran from Jul 2015 to primary completion in Jul 2023, 95 months.

How these figures are worked out, and which studies are left out of them.

Registered
Jul 14, 2025
First posted
Jul 25, 2025
StartActual
Jul 21, 2015
Primary completionActual
Jul 11, 2023
CompletionActual
May 2025
Last update
Jul 25, 2025
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Jul 25, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07086430
Lead sponsor
RenJi Hospital
Responsible party
Yue Qian (Principal investigator, RenJi Hospital) — Principal investigator
First posted
Jul 25, 2025
Start date
Jul 21, 2015
Primary completion
Jul 11, 2023
Completion
May 2025
Last update
Jul 25, 2025

Oversight

Data monitoring committee
No
FDA-regulated drug
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2025. You cannot join it, but the record below documents what was studied.

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