An interventional study of Stress Intervention in CBD, Cannabidiol and Stress, sponsored by University of Minnesota. Recruiting at 1 site in United States. Open to participants aged 21 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-07-22.
Sponsored by University of Minnesota · Not applicable, Interventional, and Basic science
The aim of this study is to determine the effects of regular cannabidiol (CBD) use on the psychobiological mechanisms of the stress response. This will be achieved by comparing acute stress responses of adults who either use or do not use CBD regularly. Correlates of CBD use, including tobacco use, will be collected.
Exclusion Criteria:
Participants will include CBD users and non users
Other: Stress Intervention
Experimental Stress: Behavioral induction of acute psychosocial and physiological stress. First, participants will be provided with a speech topic and given 4 minutes to prepare a speech that they subsequently deliver in front of evaluators and a video recorder. Then, participants will complete a mental arithmetic task in front of the evaluators for 8 minutes. Then, participants will complete a cold pressor task in which they submerge their hand in ice water for 90 seconds.
Change in subjective states (stress, anxiety, positive affect)
Participants will self-report the extent to which they have felt stressed, overwhelmed, anxious/nervous, cheerful, and happy during the last 30 minutes before acute stress, immediately after acute stress, and after a recovery period. The Subjective States Questionnaire will be used to score responses. The minimum values are 0 (not at all) and the maximum values are 7 (very strongly). Higher scores mean more stress, more anxiety, and more positive affect.
Time frame: 2.5 hours
Change in cardiovascular activity and cortisol
Saliva will be collected (for later cortisol assays) and cardiovascular activity will be measured before, during, and after acute stress.
Time frame: 2.5 hours
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Stress Disorders, Traumatic, Acute→
University of Minnesota