Effect of Aerobic Exercise on Biomarkers in Depression

Browse trials for

• Depressive Disorder, Major 2,741
• Depression 8,057

Keywords

• Depression
• Aerobic exercise
• Oxidative stress
• Growth factors

Depressive Disorder, Major

2,741 studies on the registry are indexed under Depressive Disorder, Major; 559 are open to participants now.

This study's enrollment of 40 is below the median of 80 across 2,283 interventional studies indexed under Depressive Disorder, Major.

Lead sponsor

Kutahya Health Sciences University is the lead sponsor of 209 studies on the registry; 46 are open to participants now.

Study arms

• Experimental
  Exercise Group

  Those included in the experimental group continued diaphragmatic breathing exercises every day for three weeks and walking exercises at least three days a week.

  Other: Breathing exercise · Other: Aerobic Exercise

• No intervention
  Control group

  The control group continued their routine lives, and at the end of three weeks

Interventions

• OtherBreathing exercise

  Volunteers participating in the study who were included in the experimental group performed breathing exercises every day for three weeks. They were taught to focus their attention on the hand on their abdominal area while breathing slowly through their nose and to increase abdominal movement while reducing chest movement. They were warned that during inspiration, as air filled their lungs, the hand on their abdomen should rise upward and the hand on their chest should not move excessively. Participants continued the training until they performed the exercise correctly. The diaphragmatic breathing exercise was performed for 10 minutes in the supine position during the first week, in the semi-sitting and/or sitting position during the second week, and in the standing position during the final week.

• OtherAerobic Exercise

  The ratios determined as reference values for walking training in healthy adults (reference value for women = (2.11\*height) - (2.29\*body weight) - (5.78\*age) + 667 meters - reference value for men = (7.57\*height) - (1.76\*body weight) - (5.0 2\*age) - 309 meters) was performed at 80% intensity for at least 30 minutes on at least 3 days a week for 3 weeks. Aerobic exercise was considered for 3 weeks to facilitate adaptation to exercise and sustainability.

Primary outcomes

1. Oxidative stress biomarkers

   It has been reported that the interaction between oxidative stress and the immune system is important, and that activated immune inflammatory pathways can trigger oxidative stress. In our study, an ELISA test will be conducted to investigate how exercise affects the levels of oxidative stress (TAS, TOS, MDA, and F2-isoprostane) biomarkers, which play a role in the pathophysiology of depression.

   Time frame: From enrollment to the end of treatment at 3 weeks

2. Proinflmatuar sytokines

   It is believed that increased production of key proinflammatory cytokines such as interleukin tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 (IL-1) and acute phase reactants plays an important role in the development of depression as a result of immune system involvement. In our study, an ELISA test will be conducted to investigate how exercise affects the levels of inflammation (TNF-α, IL-6, IL-1) which play a role in the pathophysiology of depression.

   Time frame: From enrollment to the end of treatment at 3 weeks

Individual participant data

Plan to share: No