An observational study in Trauma Injury and Coagulopathy, sponsored by Jubilee Mission Medical College and Research Institute. Recruiting at 1 site in India. Open to participants aged 12 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-07-02.
Sponsored by Jubilee Mission Medical College and Research Institute · Observational
Observational study to know what is the predictive accuracy of platelet-neutrophil ratio (PNR) and platelet-lymphocyte ratio (PLR) done in patients presenting to ED( emergency department)within 6 hours of trauma; in detecting early trauma induced coagulopathy during hospital admission
Trauma has a significant impact on the wellbeing and healthcare for the populations. Millions of patients seek medical help as a result of trauma, with a substantial proportion of patients suffering from life-changing or life-limiting injuries. The leading cause of traumatic death worldwide is road traffic collision, followed by suicide and homicide.(4) The role of platelets in the hemostasis and coagulation is crucial. Platelet interaction with lymphocytes, neutrophils, and monocytes modifies both the innate and adaptive immune responses.Platelets stick to the damaged endothelium and recruit leukocytes to the sites of injury.
Lymphocytes are the major cellular components of the humoral and cell-mediated immune system which include T, B, and natural killer cells. Platelet-lymphocyte ratio (PLR), platelet- neutrophil ratio (PNR) could reflect the balance between the body response to inflammation and immunity mediators Previously, few studies have tested the usefulness of PLR, PNR for predicting the outcomes in stroke , cardiovascular diseases. abdominal trauma, ARDS (Acute Respiratory Distress Syndrome) \& sepsis. I would like to do a study, where the results could be utilized in a resource limited hospital , for early referral and the prognostic value of these biomarkers in predicting ETIC in trauma.
The present study hypothesize that the on-admission PLR , PNR values would help early risk stratification and timely management of trauma patients which subsequently improve the outcomes
128 studies on the registry are indexed under Accidental Injuries; 39 are open to participants now.
This study's planned enrollment of 250 is above the median of 170 across 59 observational studies indexed under Accidental Injuries.
Browse Accidental Injuries studies →Jubilee Mission Medical College and Research Institute is the lead sponsor of 25 studies on the registry; 4 are open to participants now.
Counted across the registry records on this site, refreshed daily.
All patients with trauma AND Presenting to ED within 6 hrs of the event AND The ED Physician sends coagulation profile
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Cancer (malignancy)
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
All the trauma patients coming to ED for whom the physician send investigations
1. Sensitivity, specificity, positive and negative predictive value
PLR and PNR ratio in predicting in-hospital transfusion requirement during index hospital admission.
Time frame: 24 hours
Compare the AUROC ( Area Under the Receiver Operating Characteristic Curve) of PLR and PNR ratio in predicting in-hospital transfusion requirement during index hospital admission
PLR and PNR ratio in predicting in-hospital 30 day mortality
Time frame: 24 hours
Compare the AUROC of PLR and PNR ratio in predicting prolonged ventilatory support (>21 days)
Prolonged ventilators support
Time frame: 24 hours
Compare the incidence of emergent surgery, renal replacement therapy amongst patients developing ETIC and those who do not during the duration of hospital stay or within 30 days (whichever is earlier)
Renal replacement therapy in patients with ETIC
Time frame: 24hours
Compare the length of hospital stay, total number of surgeries, total intensive care days in numbers amongst patients developing ETIC and those who do not during the duration of hospital stay or within 30 days (whichever is earlier)
length of hospital stay, total number of surgeries, total intensive care days in numbers amongst patients developing ETIC and those who do not during the duration of hospital stay or within 30 days
Time frame: 24hours
Started Oct 2023 (actual). Primary completion is estimated for Oct 2025, 24 months after the start.
Of 33 non-industry observational studies under Accidental Injuries, half reached primary completion within 24 months of starting (the median), counting those still running; a quarter within 12 and three quarters within 60. This study's planned 24 months is close to that.
Counting every sponsor, half of 39 studies reached it within 31 months; a quarter within 12 and three quarters within 60.
How these figures are worked out, and which studies are left out of them.
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Jubilee Mission Medical College and Research Institute