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CompletedNCT07040696Updated May 29, 2026

Accuracy of Venous Excess Ultrasound Score at Hospital Admission to Predict Acute Kidney Injury

An observational study in Preeclampsia and Acute Kidney Injury, sponsored by Cairo University. Completed at 1 site in Egypt. Open to female participants aged 20 Years to 40 Years. Per ClinicalTrials.gov, last updated 2026-05-29.

Sponsored by Cairo University · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
70
Ages
20 Years to 40 Years
Sex
Female
01

Study summary

To evaluate diagnostic accuracy of venous excess ultrasound score to predict acute kidney injury

Read the detailed description

Preeclampsia is a common health problem during pregnancy. such condition may result in serious consequences including acute kidney injury. researchers of this study aim to evaluate the ability of venous excess ultrasound score at hospital admission to predict acute kidney injury in preeclampsia with severe features

02

Conditions studied

  • Preeclampsia
  • Acute Kidney Injury

Keywords

  • preeclampsia
  • VEXUS score
  • AKI
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In context

Pre-Eclampsia

882 studies on the registry are indexed under Pre-Eclampsia; 237 are open to participants now.

This study's enrollment of 70 is below the median of 163 across 380 observational studies indexed under Pre-Eclampsia.

Browse Pre-Eclampsia studies →

Lead sponsor

Cairo University is the lead sponsor of 4,780 studies on the registry; 1,427 are open to participants now.

Of its 36 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
20 Years to 40 Years
Sexes eligible
Female
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

preeclampsia with severe features

Inclusion criteria

  • preeclampsia with severe features

Exclusion criteria

Exclusion Criteria:

  • Patient refusal
  • Preexisting renal impairment (defined as baseline serum creatinine > 1.3 mg/dl)
  • Inability to obtain adequate Doppler views
  • Renal transplantation
  • Previous need for renal replacement therapy
  • Known peripheral vascular disease
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
70 participants (actual)
Patient registry
No

Groups and cohorts

  • Preeclampsia with severe features

    Features of severity will be defined according to American college of obstetric and gynacology guidelines

    Device: Venous excess ultrasound score (VEXUS)

Interventions

  • DeviceVenous excess ultrasound score (VEXUS)

    Doppler examination of inferior vena cave, portal vein, hepatic vein, and intrarenal vein will be conducted by an experienced operator

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What researchers measure

Primary outcomes

  1. The accuracy of VEXUS score at admission to predict acute kidney injury

    Time frame: within 48 hours of admission

Secondary outcomes

  1. need for renal replacement therapy

    Time frame: at 28 days of admission

  2. Cumulative fluid balance

    Time frame: within 48 hours of admission

  3. In hospital mortality

    Time frame: At 28 days of admission

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Study locations

1 site
  • Cairo University
    Cairo, Giza Governorate 6890, Egypt
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References and documents

Publications

  • Viana-Rojas JA, Argaiz E, Robles-Ledesma M, Arias-Mendoza A, Najera-Rojas NA, Alonso-Bringas AP, De Los Rios-Arce LF, Armenta-Rodriguez J, Gopar-Nieto R, Briseno-De la Cruz JL, Gonzalez-Pacheco H, Sierra-Lara Martinez D, Gonzalez-Salido J, Lopez-Gil S, Araiza-Garaygordobil D. Venous excess ultrasound score and acute kidney injury in patients with acute coronary syndrome. Eur Heart J Acute Cardiovasc Care. 2023 Jul 7;12(7):413-419. doi: 10.1093/ehjacc/zuad048. PubMed 37154067 ↗
  • Rola P, Miralles-Aguiar F, Argaiz E, Beaubien-Souligny W, Haycock K, Karimov T, Dinh VA, Spiegel R. Clinical applications of the venous excess ultrasound (VExUS) score: conceptual review and case series. Ultrasound J. 2021 Jun 19;13(1):32. doi: 10.1186/s13089-021-00232-8. PubMed 34146184 ↗
  • Naqvi R, Hossain N, Butt S, Bhellar Z, Fatima E, Imtiaz S, Moosa PG, Abbas K, Jafri SB, Khan S. Efficacy of multiple Biomarkers: NGAL, KIM1, Cystatin C and IL18 in predicting pregnancy related acute kidney injury. Pak J Med Sci. 2023 Jan-Feb;39(1):34-40. doi: 10.12669/pjms.39.1.6930. PubMed 36694779 ↗
  • Hassan M, Mayanja R, Ssalongo WGM, Robert N, Mark LH, Samson O, Muhindo R. Incidence and predictors of acute kidney injury among women with severe pre-eclampsia at Mbarara Regional Referral Hospital. BMC Nephrol. 2022 Nov 2;23(1):353. doi: 10.1186/s12882-022-02972-8. PubMed 36324072 ↗

Individual participant data

Plan to share: No — Individual participant data (IPD) may not be shared due to privacy regulations, ethical considerations

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 29, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07040696
Lead sponsor
Cairo University
Responsible party
Mina Adolf Helmy (Lecturer of anesthesia, Cairo University) — Principal investigator
First posted
Jun 27, 2025
Start date
Jun 22, 2025
Primary completion
May 27, 2026
Completion
May 27, 2026
Last update
May 29, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in May 2026. You cannot join it, but the record below documents what was studied.

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