An interventional study of Actrapid insulin and Normal saline in Prevention of Postoperative Adhesions, sponsored by Ain Shams University. Not yet recruiting. Open to female participants aged 18 Years to 50 Years. Per ClinicalTrials.gov, last updated 2025-06-05.
Sponsored by Ain Shams University · Not applicable, Interventional, and Prevention
Adhesion formation following laparoscopic pelvic surgery remains a significant cause of chronic pelvic pain, infertility, and surgical complications. Patients with insulin resistance (IR) may have heightened inflammatory responses and impaired tissue healing, contributing to a higher risk of adhesion formation. Intraperitoneal administration of insulin has shown promising results in animal models by modulating inflammatory mediators and enhancing fibrinolysis. This trial aims to evaluate the efficacy and safety of intraperitoneal insulin instillation at the end of laparoscopy in women with insulin resistance.
This is a prospective, randomized, controlled, double-blind clinical trial designed to evaluate the efficacy of intraperitoneal insulin administration at the end of laparoscopic surgery in women with insulin resistance, aiming to reduce postoperative adhesion formation. The study will be conducted at a dr saed hospital and will enroll 100 female patients diagnosed with insulin resistance undergoing laparoscopy for infertility or chronic pelvic pain.
4,278 studies on the registry are indexed under Recurrence; 987 are open to participants now.
This study's planned enrollment of 100 is above the median of 50 across 3,373 interventional studies indexed under Recurrence.
Browse Recurrence studies →Ain Shams University is the lead sponsor of 1,876 studies on the registry; 423 are open to participants now.
Of its 32 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
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Exclusion Criteria:
Drug: Actrapid insulin
Drug: Normal saline
0.1 IU/kg of short-acting human insulin diluted in 100 mL of normal saline, instilled intraperitoneally before closure
100 mL normal saline intraperitoneally
Adhesion scoring at second-look laparoscopy
Adhesion scoring at second-look laparoscopy (4-6 weeks postoperative)
Time frame: 4-6 weeks postoperatively
Postoperative pain scores
Time frame: Immediately after operation
Hypoglycemic events
Time frame: 2 hours after the operation
Hypoglycemic events
Time frame: 4 hours after the operation
Fertility rates
Time frame: At 6 months
No study locations are listed for this record.
This study is not yet recruiting, as verified in May 2025. You cannot join it, but the record below documents what was studied.
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Ain Shams University