ClinicalTrials.gg
RecruitingNCT07004881Updated Jun 18, 2025

Comparison Between the Effects of Mulligan and Maitland Mobilization on Patellofemoral Pain Syndrome

An interventional study of Group A (Active Comparator) Mulligan's Mobilization With Movement (MWM) and Group B(Experimental) Maitland's Patellar Mobilizations in Patellofemoral Pain Syndrome, sponsored by Foundation University Islamabad. Recruiting at 1 site in Pakistan. Open to participants aged 18 Years to 40 Years. Per ClinicalTrials.gov, last updated 2025-06-18.

Sponsored by Foundation University Islamabad · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Primary completion was expected by Jul 2025, 1 year 4 months ago, but the record still lists the study as recruiting.
  • Registered 10 months after the study started (first participant enrolled Jul 2024, registered May 2025).
  • Started Jul 2024; still recruiting 2 years 4 months later.

Help build ClinicalTrials.gg — short surveys, remote interviews or testing, in your language. Take part →

Phase
Not applicable
Study type
Interventional
Enrollment
40
Allocation
Randomized
Ages
18 Years to 40 Years
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-14

Among 43 studies in Patellofemoral Pain Syndrome with a site in Pakistan — 21 open to participants now, 25 under way, none of them phase 3. Patellofemoral Pain Syndrome · Pakistan.

Planned enrollment
17th of 42
40 · median 38
Started
2024
with 7 others
No phase
41 of 43
21 open now
Primary completion
2025-07
later than 15 of 24 live
Registered
29th of 43
by date
Lead sponsor
3 of 43
Foundation University Islamabad

Among the 43 studies in Patellofemoral Pain Syndrome with a site in Pakistan, this one is the 17th largest by planned enrollment of the 42 interventional ones that give a count, is one of 8 that started in 2024, is one of 41 with no phase, reaches primary completion later than 15 of the 24 other live ones, and was the 29th registered.

Patellofemoral Pain Syndrome

297 studies on the registry are indexed under Patellofemoral Pain Syndrome; 74 are open to participants now.

Browse Patellofemoral Pain Syndrome studies →

Open to participants now

21 of the 43 studies in Patellofemoral Pain Syndrome with a site in Pakistan are open now. Recruiting first, the newest first:

15 more — sign in →

All 21 open studies →

A study can be open while its sites in Pakistan have not opened yet or have stopped. Only those recruiting at a site in Pakistan →

Who these studies take

Of the 45 Patellofemoral Pain Syndrome studies recruiting now, 3 (7%) set no upper age limit and 41 (91%) stop at 75 or younger; 7 take children under 18; 13 take healthy volunteers.

This study: 18 Years to 40 Years · all sexes · no healthy volunteers.

The full table on the hub →

This tab as a report to print or save as PDF → With an account.

Was this useful?
Watch this landscapeDownload CSVNarrow it in search →With an account: a weekly mail of what changed among 43 studies in Patellofemoral Pain Syndrome with a site in Pakistan, or all of them as a file.
02

Study summary

This study is a randomised control trial and the purpose of this study is to investigate and compare the "Effects of Maitland mobilizations and Mulligan Mobilization With Movement (MWM) in patients with Patellofemoral Pain Syndrome

Read the detailed description

This study is a randomised control trial just used to investigate and compare the effects of maitland mobilizations and Mulligan's Mobilization With Movement ; with respect to:

  1. Pain
  2. Range of motion and
  3. Function in patients with Patellofemoral pain syndrome All males and females with ages of 18 to 40 years having the Patellofemoral pain syndrome can be included in this study.

A total number of 40 participants are equally and randomly divided into two groups i.e. group A and group B. Group A recieves the Mulligan Mobilization With Movement (MWM) and group B receives the Maitland's Patellar mobilizations.

Outcomes are recorded at 0 weeks and at end of 2 weeks. Outcome measure used for pain is Numeric Pain Rating Scale (NPRS), for knee ROM is goniometery and for knee function is Lower Extremity Function Scale (LEFS).

Pre and post intervention reading of all 3 measures will then be compared and data will be analysed

03

Conditions studied

  • Patellofemoral Pain Syndrome
04

Who can participate

Ages eligible
18 Years to 40 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Referred patients from rehabilitation, orthopedic and rheumatology department
  • Both males and females of age 18-40 years
  • Having pain from at least 2 months.
  • Pain score ≥ 3 on NPRS.
  • Pain on palpation of medial or lateral Patellar facet. (12, 13)
  • Retro patellar pain in at least two of the following activities:
  • Ascending , descending stairs
  • Hopping / jumping
  • prolonged sitting with flexed knees
  • kneeling and squatting
  • Patellar tilt test

Exclusion criteria

  • EXCLUSION CRIETERIA:
  • Positive tests/findings on physical examination for knee menisci, ligaments and bursa.
  • Chondromalacia patellae
  • Individuals with Instability of tibiofemoral joint
  • lower extremity surgery
  • Rheumatoid arthritis, other connective tissue disorders and congenital deformities.
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
40 participants (estimated)

Study arms

  • Active comparator
    Mulligan Mobilization with Movement

    Mulligan Mobilization with Movement This group will receive two techniques of mulligan i.e. Medial Patellar Glide relative to femoral trochlea and other is tibial internal rotation relative to femoral condyles. Both the techniques are repeated 10 times with total 3 sets. 3 sessions are performed in a week on alternate days. Total duration of interventions is 2 weeks. After mobilization, following exercises are to be performed all in 3 sets of 7 repetitions: 1. Side-lying hip abduction 2. Clamshell exercises 3. Quadriceps setting exercise 4. Vastus Medialis Oblique strengthening 5. Mini squats 6. Hamstring stretch 7. Iliotibial band stretch

    Procedure: Group A (Active Comparator) Mulligan's Mobilization With Movement (MWM)

  • Experimental
    Maitland Mobilization

    Maitland Mobilization This group recieves 4 patellar mobilization tehniques given by Maitland. For all the mobilizations the patient is positioned either in supine or sitting with 30-0 degree knee flexion or full knee extension. The therapist holds patella between his/her thumb and index finger and glides it cranially (Superior Patellar glide), caudally (Inferior Patellar Glide) and medially (Medial Patellar Glide). The fourth one i.e. Patellofemoral Distraction is given by grasping the patella between two fingers and lifting it above/away from underlying femoral trochlea. All 4 of these techniques are repeated 10 times with total 3 sets. 3 sessions are performed in a week on alternate days. Total duration of interventions is 2 weeks. After mobilization; 3 sets of 7 repetitions: 1. Side-lying hip abduction 2. Clamshell exercises 3. Quadriceps setting exercise 4. Vastus Medialis Oblique strengthening 5. Mini squats 6. Hamstring stretch 7. Iliotibial band stretch

    Procedure: Group B(Experimental) Maitland's Patellar Mobilizations

Interventions

  • ProcedureGroup A (Active Comparator) Mulligan's Mobilization With Movement (MWM)

    This group will receive two techniques of mulligan i.e. Medial Patellar Glide relative to femoral trochlea and other is tibial internal rotation relative to femoral condyles.In Medial Patellar Glide; patient is positioned supine with 40 degree knee flexion. Stabilizing hand of therapist stabilizes the posterior aspect of tibia and fibula and with mobilizing hand, the therapist gently glides the patella medially. With that, the patient is asked to actively flex and then extend the knee. In the tibial internal rotation technique; similarly the patient is positioned supine with 40 degree knee flexion. Stabilizing hand of therapist stabilizes t After mobilization; following exercises are to be performed all in 3 sets of 7 repetitions: 1. Side-lying hip abduction 2. Clamshell exercises 3. Quadriceps setting exercise 4. Vastus Medialis Oblique strengthening 5. Mini squats 6. Hamstring stretch 7. Iliotibial band stretch

  • ProcedureGroup B(Experimental) Maitland's Patellar Mobilizations

    For all the mobilizations the patient is positioned either in supine or sitting with 30-0 degree knee flexion or full knee extension. The therapist holds patella between his/her thumb and index finger and glides it cranially (Superior Patellar glide), caudally (Inferior Patellar Glide) and medially (Medial Patellar Glide). The fourth one i.e. Patellofemoral Distraction is given by grasping the patella between two fingers and lifting it above/away from underlying femoral trochlea. All 4 of these techniques are repeated 10 times with total 3 sets. 3 sessions are performed in a week on alternate days. Total duration of interventions is 2 weeks. Both groups receive similar exercises therapy following mobilizations.

06

What researchers measure

Primary outcomes

  1. Patellofemoral Pain

    It will be measured using numeric pain rating scale (NPRS). Subjects select a number ranging from 0-10 according to their intensity of pain where '0' indicates no pain while '10' indicates worst pain experienced.

    Time frame: 2 weeks

  2. Range of Motion

    Universal goniometer is used to measure knee flexion and extension ranges. Patient is positioned in supine with the knee straight and foot flat on the table. Therapist stabilizes the femur with one hand. Axis of goniometer is aligned with the lateral epicondyle of the femur, stationary arm is kept parallel to the femur and moving arm is aligned with long axis of tibia. The patient is then asked to flex and extend the knee to maximum range without pain, subsequently aligning moving arm of goniometer with new position of tibia. Angle of flexion/extension are then recorded from the goniometer and documented.

    Time frame: Variable will be assessed at before and after treatment for the total interval of 2 weeks.

  3. Lower Extremity Function

    It is measured using Lower Extremity Function Scale (LEFS). The LEFS is a questionnaire used to assess an individual's ability to perform daily activities and functional tasks related to the lower extremities (hips, knees, ankles, and feet). It comprises of total 20 questions and patients rate their ability to perform each activity on a scale from 0 (unable to perform) to 4 (able to perform without difficulty). The total score ranges from 0 to 80, with higher scores indicating better functional ability. The total sore before and after interventions of both groups is calculated and compared.

    Time frame: Variable will be assessed at before and after treatment for the total interval of 2 weeks.

07

Study locations

1 of 1 sites recruiting
08

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Started Jul 2024 (actual). Primary completion is estimated for Jul 2025, 12 months after the start.

Of 153 non-industry interventional studies with no phase under Patellofemoral Pain Syndrome, half reached primary completion within 11 months of starting (the median), counting those still running; a quarter within 4 and three quarters within 20. This study's planned 12 months is close to that.

Counting every sponsor, half of 157 studies reached it within 11 months; a quarter within 4 and three quarters within 21.

How these figures are worked out, and which studies are left out of them.

Registered
May 26, 2025
First posted
Jun 4, 2025
StartActual
Jul 15, 2024
Primary completionEst.
Jul 15, 2025
CompletionEst.
Jul 15, 2025
Last update
Jun 18, 2025
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Jun 18, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT07004881
Responsible party
Sponsor
First posted
Jun 4, 2025
Start date
Jul 15, 2024
Primary completion
Jul 15, 2025 (estimated)
Completion
Jul 15, 2025 (estimated)
Last update
Jun 18, 2025

Study contacts

Anza Moiz, DPT
Contact
anzamoiz31@gmail.com
+923350511715

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Interested in this study?

Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.

Contact study team

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion