An interventional study of Effect of Platelet Rich Fibrin on Septoplasty in Nasal Septum; Deviation and Nasal Septal Srur, sponsored by Kafrelsheikh University. Not yet recruiting. Open to participants aged Up to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-05-30.
Sponsored by Kafrelsheikh University · Not applicable, Interventional, and Other
The aim of this study is to assess the effectiveness of Platelet-Rich Fibrin (PRF) in improving postoperative healing, reducing complications, and enhancing functional outcomes in patients undergoing septoplasty
Septoplasty is a routine surgical intervention to correct nasal septal deviation, a major cause of nasal obstruction and chronic sinusitis. Despite advancements, postoperative complications-such as mucosal injury, synechiae, septal perforation, and hematoma-continue to impact outcomes and patient satisfaction.
Platelet-rich fibrin (PRF), first described by Choukroun et al., represents an autologous biomaterial rich in growth factors like PDGF, TGF-β, VEGF, and IGF-1, known to accelerate wound healing and tissue regeneration. Unlike platelet-rich plasma (PRP), PRF is easier to prepare, does not require anticoagulants, and forms a fibrin matrix conducive to sustained release of cytokines.
Several studies across disciplines-oral surgery, dermatology, orthopedics-support the regenerative potential of PRF. In nasal surgery, the delicate mucosal environment could benefit significantly from enhanced healing facilitated by PRF.
Kafrelsheikh University is the lead sponsor of 285 studies on the registry; 110 are open to participants now.
Of its 9 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
usage of platelet rich fibrin in this arm underging setoplasty
Other: Effect of Platelet Rich Fibrin on Septoplasty
traditional septoplasty
Other: Effect of Platelet Rich Fibrin on Septoplasty
it is a randomized trial of usage of platelet rich fibrin in septoplasty
Effect of submucoperichondrial application of platelet rich fibrin on healing of nasal septum mucosa after septoplasty
Mucosal Healing will be assessed by visual nasal endscope
Time frame: postoperative at 1st week , 1st month , 3rd month
No study locations are listed for this record.
Plan to share: No
No publications or documents are linked to this record.
This study is not yet recruiting, as verified in May 2025. You cannot join it, but the record below documents what was studied.
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Kafrelsheikh University