An interventional study of Left STN-DBS on, right STN-DBS off first and Right STN-DBS on, left STN-DBS off first in Parkinson Disease, Gait Disorders, Neurologic and Visuospatial/Perceptual Abilities, sponsored by Medical University of South Carolina. Recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-08-24.
Sponsored by Medical University of South Carolina · Not applicable, Interventional, and Treatment
Among 14 studies in Parkinson Disease by Medical University of South Carolina — 7 open to participants now, 7 under way, none of them phase 3. Parkinson Disease · Medical University of South Carolina.
Among the 14 studies in Parkinson Disease by Medical University of South Carolina, this one is the 8th largest by planned enrollment of the 10 interventional ones, is one of 3 that started in 2025, is one of 7 with no phase, and was the 8th registered.
4,573 studies on the registry are indexed under Parkinson Disease; 1,086 are open to participants now.
This study's planned enrollment of 12 is below the median of 40 across 3,353 interventional studies indexed under Parkinson Disease.
Browse Parkinson Disease studies →7 of the 14 studies in Parkinson Disease by Medical University of South Carolina are open now, in 1 country. Each count lists the studies.
Of the 748 Parkinson Disease studies recruiting now, 311 (42%) set no upper age limit and 127 (17%) stop at 75 or younger; 63 take children under 18; 189 take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
The full table on the hub →14 studies; the count open now beside each. This study's row is marked.
First in 2012; this study’s year is marked. 3 started in 2025.
Median enrollment 25 across the 10 interventional studies, 38 across the 4 observational. Of the 6 that completed or were terminated, 5 (83%) have results posted.
Medical University of South Carolina is the lead sponsor of 874 studies on the registry; 166 are open to participants now.
Of its 131 completed or terminated interventional studies of FDA-regulated products, 104 (79%) have results posted.
3 of the studies in Parkinson Disease by Medical University of South Carolina that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT05822388Medical University of South CarolinaCognitive Decline Following Deep Brain Stimulation | 2027-03-31 |
| NCT07536022Medical University of South CarolinaAt-home taVNS for Neurorehabilitation in Parkinson's Disease | 2027-06 |
| NCT07399496Medical University of South CarolinaAccelerated rTMS for Apathy in Parkinson's Disease | 2027-09-09 |
Among the 14 studies in Parkinson Disease by Medical University of South Carolina, from their registry updates:
The purpose of this research is to determine how deep brain stimulation (DBS) for Parkinson's disease affects attention and visuospatial function. Additionally, this study will evaluate how deficits in visual attention are associated with freezing of gait (FOG) in Parkinson's disease. There is currently no reliable treatment for FOG and little is understood about the underlying reason this occurs. Some recent research has found that stimulating the right side of the brain seems to improve FOG. The right side of the brain is also paramount for visual attention, which is why investigators are conducting this study.
FOG is a common and frequently disabling symptom of PD, affecting more than half of all PwPD. It remains a complex and incompletely understood phenomenon, with no currently approved therapies. FOG is often exacerbated during dual-tasks where attention is divided to multiple tasks. A well known method of provoking FOG by PwPD and neurologists alike is to walk through doorways or through a crowded space, regions where spatial attention is necessary. Similarly, significant visuospatial attention deficits have been found in PwPD who freeze compared to those do not. Further evidence demonstrates that the STN is part of the circuit which modulates spatial attention, and that STN-DBS has a significant impact on visuospatial attention and is notably improved with right sided stimulation. Indeed, visuospatial attention is largely considered to be predominantly lateralized to the right hemisphere. Interestingly, one study showed that right STN-DBS stimulation affecting a volume of activated tissue (VAT) connected to the right sensorimotor cortex showed a significant association with reduction in FOG. The impact of STN-DBS on visuospatial attention and the degree to which this change in attention is associated with changes in FOG has not yet been studied, and may well explain part of the pathophysiology of FOG and how to treat PwPD who freeze. The present study will build on the aforementioned research by prospectively evaluating the impact of lateralized STN-DBS stimulation on visuospatial attention in PwPD, and correlating this with change in FOG.
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STN-DBS will be turned off sequentially for each side, in this group beginning with left STN-DBS on and right STN-DBS off. This will then be followed by the corollary.
Device: Left STN-DBS on, right STN-DBS off first
STN-DBS will be turned off sequentially for each side, in this group beginning with right STN-DBS on and left STN-DBS off. This will then be followed by the corollary.
Device: Right STN-DBS on, left STN-DBS off first
There will not be any change to baseline DBS stimulation settings, only each side will be sequentially turned off during cognitive and freezing of gait assessments.
There will not be any change to baseline DBS stimulation settings, only each side will be sequentially turned off during cognitive and freezing of gait assessments.
Characterize the individual impact of lateralized STN DBS stimulation on freezing of gait in Parkinson's disease
Investigators hypothesize that right STN stimulation will have a significant association with reduction in freezing of gait, as measured by timed up and go task, compared to left STN stimulation and no stimulation.
Time frame: 1 hour
Determine if there is a correlation between the change in visuospatial function due to lateralized STN DBS stimulation and change in freezing of gait (FOG) in Parkinson's disease
Investigators hypothesize that right STN stimulation induced improvement in attention will be associated with improvement in FOG.
Time frame: 1 hour
Determine if there is a correlation between the change in Flanker task due to lateralized STN DBS stimulation in Parkinson's disease
Investigators hypothesize that right STN stimulation will have a significant association with change in attention, as measured by the flanker task, compared to left STN stimulation and no stimulation.
Time frame: 30 minutes
Determine if there is a correlation between the change in Go-No-Go task due to lateralized STN DBS stimulation in Parkinson's disease
Investigators hypothesize that right STN stimulation will have a significant association with change in attention, as measured by the Go-No-Go task, compared to left STN stimulation and no stimulation
Time frame: 30 minutes
Plan to share: No
No publications or documents are linked to this record.
Started Apr 2025 (actual). Primary completion is estimated for Jun 2028, 38 months after the start.
Of 1,291 non-industry interventional studies with no phase under Parkinson Disease, half reached primary completion within 24 months of starting (the median), counting those still running; a quarter within 11 and three quarters within 44. This study's planned 38 months is above that.
Counting every sponsor, half of 1,367 studies reached it within 25 months; a quarter within 11 and three quarters within 44.
How these figures are worked out, and which studies are left out of them.
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