An interventional study of Quantification of mild trauma brain injury risk and Biomechanical Analysis of Head Impact Forces in Trauma, Brain, sponsored by Charles University, Czech Republic. Enrolling by invitation at 1 site in Czechia. Open to participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-11-19.
Sponsored by Charles University, Czech Republic · Not applicable, Interventional, and Diagnostic
The SNIPER-TBI study aims to identify and quantify the risk of mild traumatic brain injury (mTBI) in soldiers of the Czech Armed Forces during specific high-risk training activities, including parachute jumps, high-caliber firearms shooting, artillery blasts, and Close Quarters Battle (CQB) exercises. The study will utilize both diagnostic biomarker analysis and experimental biomechanical measurements to assess the physiological impact of these activities on brain health. The ultimate goal is to reduce mTBI incidence, improve operational readiness, and extend the active service duration of soldiers through targeted preventive measures.
The SNIPER-TBI study aims to quantify the risk of mild traumatic brain injury (mTBI) in Czech Armed Forces soldiers during high-risk training activities, including parachute jumps, high-caliber firearms shooting, artillery blasts, and Close Quarters Battle (CQB) exercises. The study combines diagnostic biomarker analysis (GFAP, UCH-L1) and experimental biomechanical measurements using wearable sensors and high-speed cameras. These data will provide critical insights into the forces exerted on the brain during training and help establish exposure limits to minimize long-term neurological impairment. The results will guide the development of protective strategies and enhance soldier readiness.
1,775 studies on the registry are indexed under Brain Injuries, Traumatic; 448 are open to participants now.
This study's planned enrollment of 50 is below the median of 56 across 1,133 interventional studies indexed under Brain Injuries, Traumatic.
Browse Brain Injuries, Traumatic studies →Charles University, Czech Republic is the lead sponsor of 220 studies on the registry; 76 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Active-duty soldiers participating in high-risk training activities, including parachute jumps, high-caliber firearms shooting, artillery blasts, and Close Quarters Battle (CQB) exercises. Participants will undergo real-time biomechanical measurement and biomarker analysis to assess mild traumatic brain injury (mTBI) risk. Diagnostic biomarker analysis (GFAP, UCH-L1) Real-time biomechanical monitoring (accelerometers, high-speed cameras)
Diagnostic Test: Quantification of mild trauma brain injury risk · Other: Biomechanical Analysis of Head Impact Forces
Measure the incidence and severity of mTBI among soldiers engaged in high-risk training activities. (e.g. parachute jumps, high-caliber firearms shooting, artillery fire, explosions). Concentration of brain injury biomarkers (GFAP, UCH-L1) in blood samples collected within 24 hours post-exposure
Evaluate the mechanical forces experienced by soldiers during high-risk activities using wearable accelerometers and high-speed video analysis. Peak head acceleration (g-force) and pressure wave analysis during training activities.
Quantification of mTBI Risk 1
Measure the severity of mTBI among soldiers engaged in high-risk training activity. Concentration of brain injury biomarker glial fibrillary acidic protein (GFAP) in blood sample collected within 24 hours post-exposure. Measured in nanogram per milliliter.
Time frame: Up to 24 hours post-exposure
Quantification of mTBI Risk 2
Measure the severity of mTBI among soldiers engaged in high-risk training activity. Concentration of brain injury biomarker ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) in blood sample collected within 24 hours post-exposure. Measured in nanogram per milliliter.
Time frame: Up to 24 hours post-exposure
Biomechanical Analysis of Head Impact Forces 1
Evaluate the mechanical forces experienced by soldiers during high-risk activity using wearable accelerometers and high-speed video analysis. Peak head acceleration (g-force) will be measured during training activity. Measured in meters per second squared.
Time frame: Baseline
Biomechanical Analysis of Head Impact Forces 2
Evaluate the mechanical forces experienced by soldiers during high-risk activities using wearable accelerometers and high-speed video analysis. Pressure wave during training activity will be analyzed. Measures in Pascal.
Time frame: Baseline
Plan to share: No — Individual participant data will not be shared due to concerns regarding participant confidentiality, data privacy, and the sensitive nature of the study involving military personnel.
No publications or documents are linked to this record.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
No contact was published for this record. The registry link below has the sponsor’s details.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Charles University, Czech Republic