An interventional study of Aerobic-strength training and nutritional counseling and Cognitive training and stretching. in Aging, Alzheimer Disease and Life Style, Healthy, sponsored by Slovak Academy of Sciences. Recruiting at 1 site in Slovakia. Open to participants aged 60 Years to 80 Years. Per ClinicalTrials.gov, last updated 2025-05-29.
Sponsored by Slovak Academy of Sciences · Not applicable, Interventional, and Supportive care
Among 38 studies in Alzheimer Disease with a site in Slovakia — 8 open to participants now, 8 under way, 4 of them phase 3. Alzheimer Disease · Slovakia.
Among the 38 studies in Alzheimer Disease with a site in Slovakia, this one is the 37th largest by planned enrollment, is one of 3 that started in 2024, is one of 3 with no phase, and was the 33rd registered.
3,965 studies on the registry are indexed under Alzheimer Disease; 926 are open to participants now.
This study's planned enrollment of 40 is below the median of 70 across 3,019 interventional studies indexed under Alzheimer Disease.
Browse Alzheimer Disease studies →8 of the 38 studies in Alzheimer Disease with a site in Slovakia are open now, in 12 countries. Each count lists the studies.
Of the 641 Alzheimer Disease studies recruiting now, 283 (44%) set no upper age limit and 54 (8%) stop at 75 or younger; 34 take children under 18; 283 take healthy volunteers.
This study: 60 Years to 80 Years · all sexes · no healthy volunteers.
The full table on the hub →38 studies; the count open now beside each. This study's row is marked.
First in 2003; this study’s year is marked. 3 started in 2024.
Median enrollment 388 across the 38 interventional studies. Of the 30 that completed or were terminated, 14 (47%) have results posted.
35 of 38 have an industry lead sponsor. The 10 most frequent:
Slovak Academy of Sciences is the lead sponsor of 13 studies on the registry; 3 are open to participants now.
Slovak Academy of Sciences has 2 studies filed under Alzheimer Disease — fewer than ten, so there is no comparison to draw.
3 of the studies in Alzheimer Disease with a site in Slovakia that are under way reach primary completion within a year, 2 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06585787Phase 3Karuna Therapeutics, Inc., a Bristol Myers Squibb companyA Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4) | 2026-11-24 |
| NCT05980949Phase 3Karuna Therapeutics, Inc., a Bristol Myers Squibb companyOpen-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3) | 2027-09-07 |
| NCT06986096Slovak Academy of SciencesLifestyle for the BRAin Health - Nutrition and Exercise Training Intervention | 2026-12 |
Among the 38 studies in Alzheimer Disease with a site in Slovakia, from their registry updates:
Nothing recorded among them since 2026-09-25.
Due to the increasing incidence of dementia and the lack of causal treatment, non-pharmacological interventions represent an attractive and effective therapeutic strategy of neurodegenerative diseases, such as Alzheimer's disease.
The aim of the study is to assess the impact of a supervised 9-month intervention with aerobic-strength training and nutritional counseling compared to cognitive training and stretching on the brain, cognitive and motor functions, metabolism, physical fitnes and plasma markers of neurodegenertion in older adults at increased risk of developing Alzheimer's disease.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
A blood test of average blood sugar over the past two to three months, given as a percentage or in mmol/mol. 6.5% (48 mmol/mol) or more is the usual threshold for diabetes, normally confirmed by a second test.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
A biopsy takes a small piece of tissue to examine. “Archival tissue” is a sample already taken, for example at diagnosis, and kept by the hospital.
Whether a stored sample will do depends on when it was taken, how much there is and what the study needs. Ask whether the study accepts your stored sample or needs a new biopsy.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
HbA1c
A blood test of average blood sugar over the past two to three months, given as a percentage or in mmol/mol. 6.5% (48 mmol/mol) or more is the usual threshold for diabetes, normally confirmed by a second test.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Biopsy and archival tissue
A biopsy takes a small piece of tissue to examine. “Archival tissue” is a sample already taken, for example at diagnosis, and kept by the hospital.
Whether a stored sample will do depends on when it was taken, how much there is and what the study needs. Ask whether the study accepts your stored sample or needs a new biopsy.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Elderly volunteers participating in aerobic-strength training and nutritional counseling.
Behavioral: Aerobic-strength training and nutritional counseling
Elderly volunteers participating in cognitive training combined with stretching training.
Behavioral: Cognitive training and stretching.
The intervention consists of a structured program that includes aerobic-strength training (1h training, 3 times per week) conducted by professional trainers combined with nutritional counseling.
The intervention consists of a structured program that includes cognitive training combined with stretching training (90mins training, 2x per week).
Impact on Cognitive Functions
Overall composite score of neuropsychological testing batery (higher score better outcome)
Time frame: Measurements at the baseline and after 9-month intervention.
Effect of Interventions on Neurodegeneration Markers
Concentration of plasma neurodegeneration marker pTau 217 (in a subpopulation of patients).
Time frame: Measurements at the baseline and after 9-month intervention
Computerized Cognitive Tests
Computerised cognitive testing CogState (learning/working memory score, higher score - better outcome)
Time frame: Measurements at the baseline and after 9-month intervention.
Well-being
The World Health Organization Quality of Life questionaire (WHOQOL-BREF), 31 items, highre score better QoL.
Time frame: Measurements at the baseline and after 9-month intervention.
Glucose metabolism
oral glucose tolerance test will be perfromed to detect level of glucose intolerance (impaired glucose tolerance)
Time frame: Measurements at the baseline and after 9-month intervention.
MRI of the Brain
Imaging studies to assess structural adaptation of the brain (hippocampal volume).
Time frame: Measurements at the baseline and after 9-month intervention.
Adherence
Evaluation of participant adherence to the intervention protocol.
Time frame: Adherence will be recorded during the 9-month intervention period.
Olfactory Function
Olfactory function screening test (The Sniffin' Sticks test kit).
Time frame: Measurements at baseline and after 9-month intervention.
Microbiome Composition
Determination of feacal microbiome composition (16S sequencing).
Time frame: Measurements at baseline and after 9-month intervention.
Plan to share: No
No publications or documents are linked to this record.
Started Sep 2024 (actual). Primary completion is estimated for Dec 2026, 27 months after the start.
Of 882 non-industry interventional studies with no phase under Alzheimer Disease, half reached primary completion within 30 months of starting (the median), counting those still running; a quarter within 15 and three quarters within 51. This study's planned 27 months is close to that.
Counting every sponsor, half of 959 studies reached it within 29 months; a quarter within 15 and three quarters within 51.
How these figures are worked out, and which studies are left out of them.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
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Slovak Academy of Sciences