An observational study in Total Knee Arthroplasty, Postoperative Pain and Rebound Pain, sponsored by Konya City Hospital. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2026-04-03.
Sponsored by Konya City Hospital · Observational
This prospective observational study aims to determine the incidence and clinical impact of rebound pain after peripheral nerve blocks in patients undergoing total knee arthroplasty. Rebound pain is defined as a sudden, severe pain (NRS ≥7) emerging after block resolution. Primary outcome is the incidence of rebound pain; secondary outcomes include pain severity, rescue analgesia use, nausea, vomiting, sleep quality, and patient satisfaction.
5,093 studies on the registry are indexed under Pain, Postoperative; 1,140 are open to participants now.
This study's enrollment of 294 is above the median of 102 across 608 observational studies indexed under Pain, Postoperative.
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The study population consists of adult patients aged 18 to 70 years who are scheduled for elective unilateral total knee arthroplasty under spinal anesthesia at a tertiary care hospital. All participants will receive peripheral nerve blocks as part of a standardized multimodal analgesia protocol. Patients must be physically and cognitively able to provide consent and complete a postoperative pain diary. Those with contraindications to regional anesthesia, allergies to local anesthetics, or significant comorbidities (ASA IV and above) will be excluded.
Exclusion Criteria:
Incidence of Rebound Pain After Peripheral Nerve Block
Rebound pain is defined as a sudden, severe increase in pain occurring after the resolution of peripheral nerve block, typically within 12-24 hours postoperatively. Pain intensity will be assessed using the Numeric Rating Scale (NRS; 0 = no pain, 10 = worst imaginable pain). A score of NRS ≥7 will be considered as severe pain. Patients will record pain scores in a pain diary, and incidence will be calculated as the proportion of patients meeting the rebound pain criteria.
Time frame: Within 48 hours after surgery
Sleep Quality
Sleep quality will be assessed using a 6-item sleep questionnaire (scored 1-6, where 1 = best and 6 = worst sleep quality), covering the night before surgery and the first 7 nights postoperatively.
Time frame: From 1 day before surgery to postoperative day 7
Patient Satisfaction with Pain Management
Patients will rate their satisfaction with postoperative pain control on a 5-point Likert scale (1 = not at all satisfied, 5 = completely satisfied).
Time frame: Postoperative day 7 (via telephone follow-up)
Total Rescue Analgesic Consumption
The total dose of rescue opioid analgesics administered within the first 48 hours postoperatively will be recorded in milligrams.
Time frame: Within 48 hours after surgery
Time to First Rescue Analgesia
Time elapsed from the end of surgery to the first administration of rescue analgesia will be recorded.
Time frame: Within 48 hours after surgery
Plan to share: No — This study does not plan to share individual participant data due to institutional policies and patient confidentiality considerations.
No publications or documents are linked to this record.
This study is completed, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.
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Konya City Hospital