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RecruitingNCT06958029POAFUpdated May 6, 2025

Postoperative Atrial Fibrillation in Cardiac Surgery

An observational study in Post-operative Atrial Fibrillation, sponsored by Khon Kaen University. Recruiting at 1 site in Thailand. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-05-06.

Sponsored by Khon Kaen University · Observational

From the registry’s dates

  • Primary completion was expected by Jun 2025, 1 year 5 months ago, but the record still lists the study as recruiting.
  • Started Apr 2025; still recruiting 1 year 7 months later.
Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
275
Ages
18 Years and older
Sex
All
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Study summary

This multicenter observational study aims to investigate the incidence and identify risk factors associated with postoperative atrial fibrillation (POAF) in patients undergoing cardiac surgery at three medical centers in Thailand. The study will examine patient characteristics, surgical factors, and anesthetic management practices that may contribute to the development of this common postoperative complication.

Read the detailed description

Postoperative atrial fibrillation (POAF) is a common complication following cardiac surgery, with incidence rates reported between 15-30% after valve surgery and 18-74% after coronary artery bypass grafting. POAF typically occurs within 72 hours after surgery and is associated with increased morbidity, mortality, length of hospital stay, and healthcare costs.

The Society of Thoracic Surgeons has identified five major postoperative complications associated with cardiac surgery, including POAF, which can significantly affect patient outcomes. This multicenter observational study will examine the incidence and risk factors of POAF in cardiac surgery patients across three medical centers in Thailand: Srinagarind Hospital at Khon Kaen University, Northeastern Thailand Cardiac Center, and Surat Thani Hospital.

The study will collect data on patient demographics, comorbidities, preoperative laboratory values, perioperative characteristics, surgical procedures (valve surgery, CABG, combined procedures), and postoperative complications. By identifying risk factors associated with POAF, this study aims to develop preventive strategies and improve management protocols for patients at high risk for this complication.

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Conditions studied

  • Post-operative Atrial Fibrillation

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Keywords

  • postoperative
  • atrial fibrillation
  • cardiac surgery
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In context

Atrial Fibrillation

4,009 studies on the registry are indexed under Atrial Fibrillation; 961 are open to participants now.

This study's planned enrollment of 275 is close to the median of 300 across 1,400 observational studies indexed under Atrial Fibrillation.

Browse Atrial Fibrillation studies →

Lead sponsor

Khon Kaen University is the lead sponsor of 161 studies on the registry; 24 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Patients ubdergoing cardiac surgery

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Age ≥ 18 years
  • Patients undergoing cardiac valve surgery or coronary artery bypass grafting (CABG) procedures

Exclusion criteria

Exclusion Criteria:

  • Patients undergoing aortic surgery
  • Patients undergoing MAZE procedure
  • Incomplete medical records
  • Patients who required mechanical circulatory support before surgery
  • Patients who died during surgery or within 3 days after surgery
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Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
275 participants (estimated)
Patient registry
No

Groups and cohorts

  • Cardiac surgery

    Patients undergoing cardiac surgery

    Procedure: Cardiac surgery

Interventions

  • ProcedureCardiac surgery

    Patients receiving general anesthesia for cardiac surgery

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What researchers measure

Primary outcomes

  1. Incidence

    The incidence of POAF

    Time frame: 72 hours postoperatively

Secondary outcomes

  1. Risk factors

    Risk factors associated with POAF

    Time frame: 72 hours postoperatively

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Study locations

1 of 1 sites recruiting
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References and documents

Publications

  • Crawford TC, Magruder JT, Grimm JC, Suarez-Pierre A, Sciortino CM, Mandal K, Zehr KJ, Conte JV, Higgins RS, Cameron DE, Whitman GJ. Complications After Cardiac Operations: All Are Not Created Equal. Ann Thorac Surg. 2017 Jan;103(1):32-40. doi: 10.1016/j.athoracsur.2016.10.022. Epub 2016 Nov 22. PubMed 27884410 ↗
  • Echahidi N, Pibarot P, O'Hara G, Mathieu P. Mechanisms, prevention, and treatment of atrial fibrillation after cardiac surgery. J Am Coll Cardiol. 2008 Feb 26;51(8):793-801. doi: 10.1016/j.jacc.2007.10.043. PubMed 18294562 ↗
  • Gudbjartsson T, Helgadottir S, Sigurdsson MI, Taha A, Jeppsson A, Christensen TD, Riber LPS. New-onset postoperative atrial fibrillation after heart surgery. Acta Anaesthesiol Scand. 2020 Feb;64(2):145-155. doi: 10.1111/aas.13507. Epub 2019 Dec 2. PubMed 31724159 ↗
  • Melduni RM, Koshino Y, Shen WK. Management of arrhythmias in the perioperative setting. Clin Geriatr Med. 2012 Nov;28(4):729-43. doi: 10.1016/j.cger.2012.08.006. PubMed 23101581 ↗
  • Lopes LA, Agrawal DK. Post-Operative Atrial Fibrillation: Current Treatments and Etiologies for a Persistent Surgical Complication. J Surg Res (Houst). 2022;5(1):159-172. doi: 10.26502/jsr.10020209. Epub 2022 Mar 28. PubMed 35445200 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 6, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06958029
Responsible party
Thepakorn Sathitkarnmanee (Associate professor, Khon Kaen University) — Principal investigator
First posted
May 6, 2025
Start date
Apr 1, 2025
Primary completion
Jun 1, 2025 (estimated)
Completion
Jun 10, 2025 (estimated)
Last update
May 6, 2025

Study contacts

Sirirat Tribuddharat, MD, PhD
Contact
sirirat.tribuddharat@gmail.com
66-81-6205921
Thepakorn Sathitkarnmanee, MD
principal investigator · Khon Kaen University

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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