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CompletedNCT06957210Updated May 7, 2026

Post-Traumatic Growth Following Eye Movement Desensitization and Reprocessing Therapy Versus SSRIs in Patients With Post-Traumatic Stress Disorder

An interventional study of EMDR and SSRIs in PTSD - Post Traumatic Stress Disorder, sponsored by Asad Ullah Jan. Completed at 2 sites in Pakistan. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2026-05-07.

Sponsored by Asad Ullah Jan · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
130
Allocation
Randomized
Ages
18 Years to 60 Years
Sex
All
01

Study summary

This randomized controlled trial investigates the comparative effectiveness of Eye Movement Desensitization and Reprocessing (EMDR) therapy and selective serotonin reuptake inhibitors (SSRIs) in fostering post-traumatic growth among patients diagnosed with post-traumatic stress disorder (PTSD). Participants will be randomized to receive either EMDR therapy or standard SSRI pharmacotherapy. The primary objective is to evaluate the extent of psychological growth and recovery achieved through each intervention, aiming to guide future therapeutic strategies for PTSD.

02

Conditions studied

  • PTSD - Post Traumatic Stress Disorder

Keywords

  • PTSD
  • Post-traumatic Stress Disorder
  • Post-traumatic Growth
  • EMDR
  • Eye Movement Desensitization and Reprocessing
03

In context

Combat Disorders

135 studies on the registry are indexed under Combat Disorders; 70 are open to participants now.

This study's enrollment of 130 is above the median of 76 across 113 interventional studies indexed under Combat Disorders.

Browse Combat Disorders studies →

Lead sponsor

Asad Ullah Jan is the lead sponsor of 4 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 60 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

Clinical diagnosis of Post-Traumatic Stress Disorder (PTSD) based on DSM-5 criteria

Willingness to participate and provide informed consent

Ability to comply with study procedures

Exclusion criteria

Exclusion Criteria:

Current diagnosis of psychotic disorder, bipolar disorder, or severe major depressive episode with psychotic features

Active substance use disorder within the past 6 months

Severe cognitive impairment or inability to complete study assessments

05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
130 participants (actual)

Study arms

  • Experimental
    EMDR

    EMDR therapy

    Behavioral: EMDR

  • Active comparator
    SSRIs

    Acting as control group

    Drug: SSRIs

Interventions

  • BehavioralEMDR

    Participants will receive structured EMDR therapy sessions conducted by trained therapists following standard EMDR protocols. Sessions will occur weekly over a 6 week period.

  • DrugSSRIs

    Participants will receive pharmacotherapy with an SSRI prescribed according to standard clinical guidelines for PTSD, monitored by a psychiatrist over a 6-week period.

06

What researchers measure

Primary outcomes

  1. Post-Traumatic Growth (PTG) measured by Post-Traumatic Growth Inventory (PTGI)

    Change in PTGI total score from baseline to 6 weeks.

    Time frame: 6 weeks

Secondary outcomes

  1. PTSD symptom severity measured by PTSD Checklist

    Change in PTSD Checklist total score from baseline to 6 weeks.

    Time frame: 6 weeks

07

Study locations

2 sites
  • Combined Military Hospital
    Nowshera, KPK 25770, Pakistan
  • Department of Psychiatry, Combined Military Hospital Nowshera
    Nowshera, KPK 25770, Pakistan
08

References and documents

Individual participant data

Plan to share: No — Privacy concerns and confidentiality protections for participants limit the feasibility of public data sharing.

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 7, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06957210
Lead sponsor
Asad Ullah Jan
Responsible party
Asad Ullah Jan (Head Department of Psychiatry, Combined Military Hospital Nowshera) — Sponsor-investigator
First posted
May 4, 2025
Start date
May 6, 2025
Primary completion
Nov 30, 2025
Completion
Dec 31, 2025
Last update
May 7, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in May 2026. You cannot join it, but the record below documents what was studied.

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