An interventional study of Chest Physical Therapy (CPT) modalities , Medical Treatment in Hypoxic Ischemic Encephalopathy of Newborn, sponsored by Cairo University. Not yet recruiting. Open to participants aged 1 Day to 10 Days. Per ClinicalTrials.gov, last updated 2025-04-30.
Sponsored by Cairo University · Not applicable, Interventional, and Treatment
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Hypoxic-ischemic encephalopathy (HIE) is a dangerous illness that happens when a newborn's brain does not receive adequate oxygen and blood flow, which can result in serious effects such as cerebral palsy and epilepsy. Infant diagnosed with HIE required ventilator support and subsequently developed pneumonia. They experienced respiratory problems and feeding challenges. Chest Physical Therapy is the best modalities to clear chest and improve ventilation.
The purpose of this study to investigate the effect of chest physical therapy on Arterial Blood Gases for neonates post hypoxic ischemic encephalopathy (HIE) in Neonatal intensive care unit.
Methods: Fifty neonates from both sexes, age from birth to 10 days, post HIE with chest problems were selected from neonatal intensive care unit (NICU) at Minia University hospital, Egypt. They were divided into two equal groups, control group (CG) received traditional medical treatment according to American Academy of Pediatrics (AAP) recommendations and study group (SG) received traditional medical treatment plus Chest Physical Therapy (CPT) modalities in the form of postural drainage, percussion and vibration. The sessions will apply once daily for 6 days/week, each session is about 30 minutes, according to the neonate tolerance till complete clinical cure and discharge from NICU.
the outcome will measure by Timing of Arterial blood gases improvement, Duration required for clinical improvement, Duration of Mechanical ventilation, Duration of Hospitalization.
261 studies on the registry are indexed under Hypoxia-Ischemia, Brain; 94 are open to participants now.
This study's planned enrollment of 50 is close to the median of 50 across 156 interventional studies indexed under Hypoxia-Ischemia, Brain.
Browse Hypoxia-Ischemia, Brain studies →Cairo University is the lead sponsor of 4,941 studies on the registry; 1,457 are open to participants now.
Of its 37 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
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Exclusion Criteria:
Study group
Other: Chest Physical Therapy (CPT) modalities , Medical Treatment
Control group
Other: Chest Physical Therapy (CPT) modalities , Medical Treatment
Chest Physical Therapy (CPT) modalities in the form of postural drainage, percussion and vibration.
Timing of Arterial blood gases improvement
Time needed to improve Arterial blood gases due to CPT
Time frame: 3-14 days
Timing required for clinical improvement
Time needed to improve clinical signs due to CPT
Time frame: 3-14 days
Timing needed for Mechanical Ventilation
Time needed to Mechanical Ventilation support.
Time frame: 3-7 days
Hospitalization time
All staying duration need for the neonates from admission till discharge from the hospital.
Time frame: 5-21 days
No study locations are listed for this record.
Start is estimated for May 2025; primary completion for Jun 2025, 1 month later.
Of 46 non-industry interventional studies with no phase under Hypoxia-Ischemia, Brain, half reached primary completion within 33 months of starting (the median), counting those still running; a quarter within 19 and three quarters within 63. This study's planned 1 month is below that.
Counting every sponsor, half of 47 studies reached it within 33 months; a quarter within 19 and three quarters within 63.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Apr 2025. You cannot join it, but the record below documents what was studied.
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