An observational study in Prosthesis Failure, sponsored by University Hospital, Brest. Enrolling by invitation at 1 site in France. Per ClinicalTrials.gov, last updated 2025-04-15.
Sponsored by University Hospital, Brest · Observational
The reconstruction of the distal femur using modular systems has become increasingly popular over the years, surpassing primary arthrodesis or amputation. Despite the significant advantages of using megaprostheses, complications are not uncommon. Although the Limb Preservation System™ (LPS™, DePuy Synthes; Warsaw, USA) is one of the most widely used megaprostheses in the French market, there is currently no national evaluation of this system, and only two studies have been conducted worldwide.
The aim of our study is to present the mid-term survival rates of the LPS™ implant in order to answer three main questions:
The secondary objective is to analyze the occurrence of specific failures, providing insights for potential improvements in the design and use of the LPS™ implant.
119 studies on the registry are indexed under Prosthesis Failure; 35 are open to participants now.
This study's planned enrollment of 77 is below the median of 119 across 49 observational studies indexed under Prosthesis Failure.
Browse Prosthesis Failure studies →University Hospital, Brest is the lead sponsor of 601 studies on the registry; 136 are open to participants now.
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The institutional databases of university hospitals belonging to the HugOrtho network (Hôpitaux Universitaires du Grand Ouest) will be examined to identify patients who will have undergone reconstruction using the Limb Preservation System™ (LPS™, DePuy Synthes; Warsaw, USA) for segmental resection of the distal femur, regardless of the indication.
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Exclusion Criteria:
Reconstruction using the Limb Preservation System™ for segmental resection of the distal femur.
LPS stent failure
Failure will be defined as the replacement of the femoral anchorage or amputation.
Time frame: From enrollment to last consultation
complications of the LPS stent
Complications will be defined according to Henderson's classification.
Time frame: From enrollment to last consultation
Surgical revision of the LPS stent
Any reoperation on the knee after the LPS one
Time frame: From enrollment to last consultation
Plan to share: Yes — All collected data that underlie results in a publication
Supporting information: Study protocol
Time frame: Data will be available beginning three years and ending fifteen years following the final study report completion
Access criteria: Data access requests will be reviewed by the internal committee of Brest UH. Requestors will be required to sign and complete a data access agreement
No publications or documents are linked to this record.
Started Nov 2024 (actual). Primary completion is estimated for Jul 2025, 8 months after the start.
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No contact was published for this record. The registry link below has the sponsor’s details.
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