An observational study in Nausea and Vomiting, Postoperative, Cesarean Delivery and Spinal Anesthesia, sponsored by University of Liege. Recruiting at 2 sites in Belgium. Open to female participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-04-15.
Sponsored by University of Liege · Observational
The aim of this study is to learn about the incidence and risk factors of nausea and vomiting during planned caesarean section under spinal anesthesia.
The main question it aims to answer is : What are the incidence and risks factors of postoperative nausea and vomiting (NV) during planned caesarean section under spinal anesthesia with administration of intrathecal morphine and multimodal antiemetic prophylaxis ?
Patients who will be managed according to the standard protocol in use in the department will have to answer specific questions about NV in the post-interventional recovery room and on 2 further visits in the first 24 hours post-caesarean section.
629 studies on the registry are indexed under Postoperative Nausea and Vomiting; 113 are open to participants now.
This study's planned enrollment of 400 is above the median of 197 across 88 observational studies indexed under Postoperative Nausea and Vomiting.
Browse Postoperative Nausea and Vomiting studies →University of Liege is the lead sponsor of 250 studies on the registry; 49 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients admitted for delivery at the CHU de Liège - Notre Dame des Bruyères site and the CHR de la Citadelle site.
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Any patient requiring elective caesarean section under spinal anesthesia, at a gestational age >37 weeks of amenorrhea in the context of a single-fetal pregnancy.
Exclusion Criteria:
Failure to understand the French language; Contraindication to locoregional anesthesia; Nausea and/or vomiting in the 24 hours preceding the procedure; Type 1 or type 2 insulin-requiring non-gestational diabetes; Allergy or contraindication to one of the products used in the usual management protocol; Severe preeclampsia; Height \<150 cm
Incidence of nausea and vomiting
The primary endpoint will be the incidence of PONV, including the incidence of nausea requiring rescue medication; the incidence of nausea delaying resumption of oral intake (drinks, food or analgesics); and the incidence of vomiting.
Time frame: From cesarean section to the 24th postoperative hour
Risk factors of PONV
Risk factors will be evaluated among maternal, obstetrical, neonatal, procedural and anesthetic data.
Time frame: From enrollment to the 24th postoperative hour
Plan to share: Undecided
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