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RecruitingNCT06921239LEDHLAUpdated Jan 16, 2026

HLA Antibodies in Systemic Lupus Erythematosus

An observational study in HLA Antibodies and Systemic Lupus Erythematosus, sponsored by Centre Hospitalier Universitaire, Amiens. Recruiting at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-01-16.

Sponsored by Centre Hospitalier Universitaire, Amiens · Observational

From the registry’s dates

  • Started Feb 2025; still recruiting 1 year 7 months later.
Study type
Observational
Model
Case-only
Time perspective
Retrospective
Enrollment
30
Ages
18 Years and older
Sex
All
01

Study summary

Patients suffering from autoimmune diseases show false-positive results when anti-HLA antibodies are identified. This false positivity makes it difficult to obtain an organ transplant based on immunological compatibility (absence of anti-HLA antibodies directed against graft antigens). The objectives of this project are to study the prevalence of these false positivities in a population of lupus patients, and to evaluate biological tests that can negate these false positivities.

02

Conditions studied

  • HLA Antibodies
  • Systemic Lupus Erythematosus

Keywords

  • HLA antibodies
  • systemic lupus erythematosus
03

In context

Lupus Erythematosus, Systemic

1,202 studies on the registry are indexed under Lupus Erythematosus, Systemic; 399 are open to participants now.

This study's planned enrollment of 30 is below the median of 140 across 283 observational studies indexed under Lupus Erythematosus, Systemic.

Browse Lupus Erythematosus, Systemic studies →

Lead sponsor

Centre Hospitalier Universitaire, Amiens is the lead sponsor of 576 studies on the registry; 178 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients Adults - Followed in the internal medicine department of Amiens University Hospital - With systemic lupus erythematosus - Without HLA immunization risk factors (no history of pregnancy, transfusions or transplants) - With sera stored in the biobank

Inclusion criteria

  • Patients Adults
  • Followed in the internal medicine department of Amiens University Hospital - With systemic lupus erythematosus
  • Without HLA immunization risk factors (no history of pregnancy, transfusions or transplants)
  • With sera stored in the biobank

Exclusion criteria

Exclusion Criteria:

  • minor Patients
  • Opposing the re-use of their personal data for research purposes
05

Study design

Observational model
Case-only
Time perspective
Retrospective
Enrollment
30 participants (estimated)
Patient registry
No
06

What researchers measure

Primary outcomes

  1. prevalence of unexplained antibody positivity

    prevalence of unexplained antibody positivity

    Time frame: 6 months

07

Study locations

1 of 1 sites recruiting
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 16, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06921239
Lead sponsor
Centre Hospitalier Universitaire, Amiens
Responsible party
Sponsor
First posted
Apr 10, 2025
Start date
Feb 10, 2025
Primary completion
Nov 2026 (estimated)
Completion
May 2027 (estimated)
Last update
Jan 16, 2026

Study contacts

Nicolas GUILLAUME, Pr
Contact
guillaume.nicolas@chu-amiens.fr
33+322087046

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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