ClinicalTrials.gg
RecruitingNCT06915740e-PUREUpdated Apr 8, 2025

Virtual Pulmonary Rehabilitation Program for COPD Patients; a Pilot Study

An interventional study of Exercise in COPD (Chronic Obstructive Pulmonary Disease), sponsored by Turku University Hospital. Recruiting at 2 sites in Finland. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-04-08.

Sponsored by Turku University Hospital · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Primary completion was expected by Jun 2026, 4 months ago, but the record still lists the study as recruiting.
  • Started Mar 2025; still recruiting 1 year 7 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
50
Allocation
Not applicable
Ages
18 Years and older
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-12

Among 52 studies in Pulmonary Disease, Chronic Obstructive with a site in Finland — 4 open to participants now, 4 under way, 2 of them phase 3. Pulmonary Disease, Chronic Obstructive · Finland.

Planned enrollment
47th of 48
50 · median 715
Started
2025
with 1 other
No phase
5 of 52
1 open now
Registered
51st of 52
by date
Lead sponsor
2 of 52
Turku University Hospital

Among the 52 studies in Pulmonary Disease, Chronic Obstructive with a site in Finland, this one is the 47th largest by planned enrollment of the 48 interventional ones, is one of 2 that started in 2025, is one of 5 with no phase, and was the 51st registered.

By phase

52 studies; the count open now beside each. This study's row is marked.

Phase 329 · 2 open
Phase 211 · 0 open
No phasethis study5 · 1 open
Observational4 · 1 open
Phase 43 · 0 open

By the year they started

First in 2000; this study’s year is marked. 2 started in 2025.

Size and results

Median enrollment 715 across the 48 interventional studies, 363 across the 4 observational. Of the 47 that completed or were terminated, 33 (70%) have results posted.

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Watch this landscapeDownload CSVWith an account: a weekly mail of what changed among 52 studies in Pulmonary Disease, Chronic Obstructive with a site in Finland, or all of them as a file.
02

Study summary

The goal of this pilot study is to investigate the feasibility of a virtual rehabilitation program in COPD patients. The main questions it aims to answer are:

  1. To facilitate a safe rollout of the remote rehabilitation program for COPD patients in Southwest Finland.
  2. To identify and subsequently improve limitations of the rehabilitation program.
  3. To evaluate the levels of participant engagement and adherence to the digital COPD rehabilitation program over an extended period to understand its sustainability and long-term impact.
  4. To determine the effectiveness of the digital COPD rehabilitation program in improving lung function, exercise capacity, and quality of life among participants
  5. To assess the impact of the digital program on healthcare resource utilization, including hospital readmissions, emergency room visits, and outpatient visits related to COPD management.
  6. To measure participant satisfaction, usability, and overall experience with the digital platform to identify areas for improvement and enhance user engagement.
  7. To evaluate the cost-effectiveness of implementing the digital program compared to conventional rehabilitation methods, considering direct healthcare costs.

Participants will be enrolled in a virtual rehabilitation program, and a proportion of the patients is invited for focus group discussion to assess their experiences.

Read the detailed description

The e-PURE study is an investigator initiated study, which aims to evaluate the feasibility, effectiveness, and long-term outcomes of a digital pulmonary rehabilitation program designed for patients with Chronic Obstructive Pulmonary Disease (COPD) in Southwest Finland. This pilot study assesses patient adherence, lung function, exercise capacity, quality of life, and the program's potential impact on healthcare utilization.

COPD is a common disease, affecting mostly elderly, with significant impact on life expectancy and quality of life. Pulmonary rehabilitation (PR) is an essential intervention for COPD patients, known to enhance health-related quality of life and reduce symptoms like shortness of breath. Traditional PR programs are underutilized due to accessibility barriers, with less than 1% of COPD patients in Canada and 3.7% in the U.S. attending such programs. The COVID-19 pandemic exacerbated these challenges by halting in-person PR programs. Virtual PR offers a promising, non-inferior alternative. The e-PURE study responds to this need by rolling out a digital rehabilitation program developed by a multidisciplinary team of healthcare professionals.

This is a single-arm observational pilot study enrolling up to 50 COPD patients. The rehabilitation program spans around 12 weeks, with follow-up assessments at 16 and 26 weeks post-enrolment. Patients undergo a tailored rehabilitation plan that includes individualized exercise routines, nutritional counselling, and smoking cessation support. Progress is reported through questionnaires and clinical evaluations such as the 6-minute walk test.

The primary outcome measure is the improvement in distance during the 6-minute walk test after the program, compared to baseline. Secondary outcomes include patient satisfaction, changes in the St. George Respiratory Questionnaire, and healthcare resource utilization (hospital readmissions, emergency visits).

The pilot study will identify whether a larger follow-up study is feasible, and indicate the number of patients to recruit.

03

Conditions studied

  • COPD (Chronic Obstructive Pulmonary Disease)

Keywords

  • copd
  • pulmonary rehabilitation
  • telemedicine
  • exercise
04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  1. Participation in the remote rehabilitation program for patients, fulfilling criteria 1a, 1b and 1c 1a Documented COPD diagnosis (ICD 10 code J44) 1b Expected survival > 1 year 1c Sufficient technical and language skills for safe participation in the program
  2. Signed

Exclusion criteria

Exclusion Criteria:

  • Severe comorbidities with expected survival of less than 1 year
  • Clinical suspicion that remote rehabilitation may be unsafe.
Terms in these criteria, in plain language(2)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

COPD

Chronic obstructive pulmonary disease: long-term lung disease that makes it hard to breathe out, including emphysema and chronic bronchitis.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
50 participants (estimated)

Study arms

  • Other
    virtual pulmonary rehabilitation

    Participation in a virtual pulmonary rehabilitation program developed by a multidisciplinary team

    Other: Exercise

Interventions

  • OtherExercise

    virtual rehabilitation, including endurance exercise, strength training, breathing exercises, patient education, dietary advice

06

What researchers measure

Primary outcomes

  1. 6 minutes walking test

    6 minutes walking test after the rehabilitation program in comparison to baseline

    Time frame: from enrollment to 16-26 weeks

07

Study locations

1 of 2 sites recruiting
  • Turku University Hospital
    Turku, Southwest Finland 20540, Finland
    Recruiting
    • Matthijs Feuth, MD PhD · Contactmatfeu@utu.fi · +358505222163
    • Maritta Kilpeläinen, MD PhD · Contactmaritta.kilpalainen@varha.fi · +358505663340
    • Henrik Söderström, MD · Sub investigator
    • Matthijs Feuth, MD PhD · Principal investigator
    • Riika Liukkonen, MD · Sub investigator
    • Chrisna Ravyse, PhD · Sub investigator
    • Janne Hänninen, MD · Sub investigator
  • Turku University Hospital
    Turku, 20540, Finland
    Not yet recruiting
    • Matthijs Feuth, MD PhD · Contactmatfeut@utu.fi · +358505222163
    • Maritta Kilpeläinen, MD PhD · Contactmaritta.kilpelainen@varha.fi · +35823134739
    • Henrik Söderström, MD · Sub investigator
    • Maritta Kilpeläinen, MD PhD · Sub investigator
    • Matthijs Feuth, MD PhD · Principal investigator
    • Riika Liukkonen, MD · Sub investigator
    • Chrisna Ravyse, PhD · Sub investigator
08

References and documents

Publications

  • Holland AE, Cox NS, Houchen-Wolloff L, Rochester CL, Garvey C, ZuWallack R, Nici L, Limberg T, Lareau SC, Yawn BP, Galwicki M, Troosters T, Steiner M, Casaburi R, Clini E, Goldstein RS, Singh SJ. Defining Modern Pulmonary Rehabilitation. An Official American Thoracic Society Workshop Report. Ann Am Thorac Soc. 2021 May;18(5):e12-e29. doi: 10.1513/AnnalsATS.202102-146ST. PubMed 33929307 ↗
  • Cox NS, Dal Corso S, Hansen H, McDonald CF, Hill CJ, Zanaboni P, Alison JA, O'Halloran P, Macdonald H, Holland AE. Telerehabilitation for chronic respiratory disease. Cochrane Database Syst Rev. 2021 Jan 29;1(1):CD013040. doi: 10.1002/14651858.CD013040.pub2. PubMed 33511633 ↗
  • Janjua S, Banchoff E, Threapleton CJ, Prigmore S, Fletcher J, Disler RT. Digital interventions for the management of chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2021 Apr 19;4(4):CD013246. doi: 10.1002/14651858.CD013246.pub2. PubMed 33871065 ↗

Study documents

PDFs hosted by the registry, ClinicalTrials.gov.

Individual participant data

Plan to share: No — Privacy policy does not allow to share individual participant data

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Started Mar 2025 (actual). Primary completion is estimated for Jun 2026, 14 months after the start.

Of 1,094 non-industry interventional studies with no phase under Pulmonary Disease, Chronic Obstructive, half reached primary completion within 22 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 41. This study's planned 14 months is below that.

Counting every sponsor, half of 1,181 studies reached it within 22 months; a quarter within 10 and three quarters within 39.

How these figures are worked out, and which studies are left out of them.

Registered
Mar 31, 2025
First posted
Apr 8, 2025
StartActual
Mar 31, 2025
Primary completionEst.
Jun 30, 2026
CompletionEst.
Jun 30, 2026
Last update
Apr 8, 2025
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Apr 8, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06915740
Responsible party
Matthijs Feuth (MD PhD, Turku University Hospital) — Principal investigator
First posted
Apr 8, 2025
Start date
Mar 31, 2025
Primary completion
Jun 30, 2026 (estimated)
Completion
Jun 30, 2026 (estimated)
Last update
Apr 8, 2025

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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