An observational study in Postoperative Pain, sponsored by Assuta Medical Center. Completed. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-04-03.
Sponsored by Assuta Medical Center · Observational
Postoperative pain management is critical for surgical recovery, affecting patient outcomes, hospitalization duration, and quality of life. Variability in pain perception and medication needs among surgical patients poses a challenge in clinical practice. Identifying predictive factors for pain severity and analgesic use could enhance personalized pain management strategies.
Cannabis, containing cannabinoids with analgesic and anti-inflammatory properties, has garnered attention as a potential pain management option for surgical patients. The effectiveness of cannabis varies, depending on surgery type, severity, and individual pain tolerance. Some studies suggest cannabis users may experience heightened pain sensitivity and require more analgesics, while others highlight its potential to reduce opioid use. Despite growing interest, the use of cannabis in surgery remains controversial due to a lack of large-scale clinical trials evaluating its safety and efficacy in this setting.
Some research indicates cannabis use could lower pain levels post-surgery and reduce opioid needs. However, other studies raise safety concerns, and conflicting findings have yet to establish its role conclusively. Given these uncertainties, healthcare professionals must carefully monitor cannabis use in surgical patients. Patients should inform providers of any cannabis use before surgery to ensure appropriate pain management and minimize risks.
This study aims to analyze pain intensity and analgesic usage patterns across various surgeries using real-world medical data. Machine learning models will predict high analgesic needs, focusing on cannabis users. This research seeks to optimize postoperative pain treatment and personalize clinical strategies.
Study Design This retrospective cohort study analyzes anonymized medical records of surgical patients who underwent surgery between January 2017 and January 2025 at the Assuta hospitals network.
Data Source Electronic health records from a hospital database, including postoperative pain scores, analgesic administration, and patient demographics. Pain levels will be assessed during hospitalization for up to one-week post-surgery. In the cannabis use research group, participants will be asked to report their daily use for at least the past six months. The study will utilize MDClone, a healthcare data analytics platform, to extract and analyze anonymized electronic health records. MDClone enables the generation of synthetic, privacy-preserving patient data, ensuring compliance with ethical and regulatory standards while allowing for robust statistical analysis.
Variables for Analysis
The study population The expected number of participants is 70,000 participants from the five medical canters in the Assuta network.
Statistical analysis include:
5,093 studies on the registry are indexed under Pain, Postoperative; 1,140 are open to participants now.
This study's enrollment of 70,000 is above the median of 102 across 608 observational studies indexed under Pain, Postoperative.
Browse Pain, Postoperative studies →Assuta Medical Center is the lead sponsor of 41 studies on the registry; 1 is open to participants now.
Counted across the registry records on this site, refreshed daily.
All patients that underwent painfull surgical procedures will be cosidered in the study.
Exclusion Criteria:
Patients that underwent surgical procedures
Patients that use cannabis due to medical conditions causing chronic pain and underwent surgical procedure.
Pain Intensity
To assess the impact of cannabis use on postoperative pain intensity (measured using the To assess the impact of cannabis use on postoperative pain intensity (measured using the Visual Analog Scale, VAS in a scale from 0 -no pain- to 10 -worst pain possible-)
Time frame: 7 days
Analgesic Consumption
total amount of analgesics required during the postoperative period including opioids
Time frame: 7 days
No study locations are listed for this record.
This study is completed, as verified in Mar 2025. You cannot join it, but the record below documents what was studied.
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Assuta Medical Center